Latest Interviews
Showing 1–4 of 4 transcripts.
Clear all filters- a16z42 min
Ben Horowitz on the Global Race for Tech, Power, and Influence
Ben Horowitz, Anne Neuberger, Raghu Raghuram, Jen Kha
Andreessen Horowitz is formally launching a global strategy that expands its operations beyond Silicon Valley to secure American technological leadership through dedicated offices in San Francisco and strategic partnerships in key allied regions like Japan, Mexico, and the Middle East. The firm leverages its unique government relations and industry networks to help portfolio companies navigate complex, non-transactional international markets, explicitly aiming to embed democratic values into global AI infrastructure while countering authoritarian tech models. By integrating capital with diplomatic and commercial alliances, the strategy focuses on accelerating the global expansion of U.S. startups and strengthening national security through private-sector innovation in defense and cybersecurity.
- a16z29 min
The $100 Billion Promise: How NASA is Returning to The Moon | Jared Isaacman on The a16z Show
Jared Isaacman, Morgan Brennan
NASA Administrator Jared Isaacman has outlined an aggressive strategy to secure a permanent lunar base by the end of the current presidential term, aiming to compress launch cycles from years to months through budget reallocation and workforce restructuring. The plan prioritizes in-housing core competencies like Mission Control while leveraging commercial partners SpaceX and Blue Origin for iterative risk reduction ahead of 2028 crewed missions. This approach reframes lunar exploration as a national security imperative that serves as a critical proving ground for future nuclear-powered operations on Mars and Europa.
- a16z30 min
What You Missed in AI This Week (Google, Apple, ChatGPT)
Google's VO3 model and recent updates to ChatGPT voice and Apple Intelligence are driving a rapid shift toward autonomous video and narrative creation, allowing users to generate consistent multi-character scenes and human-like dialogue from single text prompts. These technological leaps, alongside Eleven Labs' emotion-tagging capabilities and data showing a doubling of consumer AI startup revenue, are establishing a "faceless" creator economy where entrepreneurs can build full-stack brands using AI-generated assets. While current limitations in character consistency and high inference costs persist, the industry is rapidly moving from experimental novelty to a dominant force in social media and professional workflows.
- a16z27 min
CRISPR 2.0 and the Future of Gene Therapies
The gene therapy sector is undergoing a paradigm shift from simple transgene addition to precise CRISPR-based editing, driven by recent FDA approvals and a pipeline projecting dozens of Phase 3 trials this year. Despite significant progress in developing base editors and expanding delivery vectors, the industry faces critical bottlenecks in manufacturing scalability and achieving organ-specific targeting without immunogenicity. Successful organizations are distinguishing themselves by combining rigorous engineering mindsets with interdisciplinary teams to optimize modalities and automate production for a future of millions of patients.