Latest Interviews
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Clear all filters- All-In Podcast38 min
Bryan Johnson: I Just Took the Most Powerful Dose of DMT in the World... Here's What It Was Like
Bryan Johnson, David Friedberg
Brian Johnson reports that ingesting a high dose of 5-MeO-DMT induced a 48-hour session of total ego dissolution, effectively annihilating the brain's Default Mode Network to produce a profound metabolic reset and restored youthful neural connectivity. He interprets these neurological changes as a critical mechanism for anti-aging and psychological rejuvenation, complementing his broader longevity protocols that include mitochondrial transplantation, FoxO3 gene therapy, and personalized stem cell organoids. By framing psychedelics as essential tools for "psycho-flexibility" against rapid AI-driven change, Johnson aims to normalize these interventions while acknowledging the risks of unregulated use and the philosophical implications for personal identity.
- All-In Podcast21 min
Sergey Brin | All-In Summit 2024
Google co-founder Sergey Brin, who has resumed active technical leadership, asserts that artificial intelligence represents a fundamental rewrite of information retrieval comparable to the invention of the internet. Addressing the company's strategic direction, Brin emphasizes the necessity of deploying powerful AI tools despite occasional errors to foster rapid experimentation, while warning against blind extrapolation of hardware scaling without parallel algorithmic improvements. Looking forward, he predicts that the convergence of general-purpose models with multimodal capabilities will soon drive robust robotics and new forms of human-computer interaction, positioning the current era as a non-zero-sum landscape for global value creation.