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  1. 80,000 Hours1h 3m

    #28 - Dr Cotton-Barratt on why scientists should need insurance, PhD strategy & fast AI progresses

    Dr Cotton-Barratt, Dr Owen Cotton-Barratt, Keiran Harris, Rob Wiblin

    Owen Cotton Barrett advocates for early-career researchers to prioritize high-impact problems over academic prestige and proposes internalizing scientific liability through insurance mechanisms to address catastrophic risks like pandemics. He further outlines a diversified AI safety strategy that balances immediate action with long-term infrastructure building, noting that the Future of Humanity Institute is launching a new program to support pre-paradigmatic research without requiring a PhD. The discussion also highlights upcoming EA Global events in San Francisco, London, and other locations as key opportunities for community engagement in these fields.

  2. 80,000 Hours55 min

    #24 - Stefan Schubert on why it’s a bad idea to break the rules, even if it’s for a good cause

    Stefan Schubert, Keiran Harris, Rob Wiblin

    Stefan Schubert examines the tension between epistemic modesty and effective altruism's cultural cohesion, warning that overconfidence and political tribalism threaten the movement's rational foundations while urging a shift toward specialized expertise. He analyzes organizational trends where talent gaps now overshadow funding constraints and highlights the slow pace of "creative destruction," noting that the community's reputation for integrity remains a fragile asset that demands strict adherence to norms over short-term gains. Ultimately, Schubert clarifies the concept of cause neutrality to argue that deep confidence in existential risks like AI safety can coexist with a willingness to update beliefs, provided the movement avoids irreversible political entanglements and continues expanding its reach into the developing world.

  3. 80,000 Hours1h 8m

    #22 - Dr Leah Utyasheva on the non-profit that figured out how to massively cut suicide rates

    Dr Leah Utyasheva, Keiran Harris, Rob Wiblin

    Founded in 2016 by Leah Utyasheva and Professor Michael Eddleston, the Centre for Pesticide Suicide Prevention advocates for banning highly toxic Class 1A pesticides to address the 150,000 annual deaths caused by impulsive agricultural self-poisoning. Backed by a GiveWell grant and affiliated with the University of Edinburgh, the organization is collecting hospital data from India and Nepal to demonstrate that restricting access to these lethal means is a cost-effective strategy, having already saved 93,000 lives in Sri Lanka. This evidence-based approach aims to persuade local regulators to prioritize means reduction over ineffective safe storage measures, thereby relieving overwhelmed health systems and fulfilling government obligations to protect citizen safety.

  4. 80,000 Hours1h 18m

    #20 - Bruce Friedrich on inventing outstanding meat substitutes to end speciesism & factory farming

    Bruce Friedrich, Natalie Cargill, Keiran Harris, Rob Wiblin

    The Good Food Institute executes a strategy to displace industrial animal agriculture by accelerating the development of plant-based and clean meats that compete on price, taste, and convenience rather than ethical appeal. While current market share for alternatives remains below 1% amidst a record 9 billion annual animal slaughters, industry experts project cost parity with conventional meat within a decade through bioreactor scaling and synthetic biology. Operating as a rapidly expanding nonprofit funded entirely by philanthropy, the organization targets a 2050 vision where these technologies collectively fulfill 100% of global meat demand.

  5. 80,000 Hours1h 5m

    #19 - Samantha Pitts-Kiefer on working next to the White House trying to prevent nuclear war

    Samantha Pitts-Kiefer, Keiran Harris, Rob Wiblin

    The Nuclear Threat Initiative, founded by Sam Nunn and Ted Turner, outlines critical risks of nuclear terrorism and great power miscalculation through insights from Senior Director Samantha Pitts-Kyfer. The analysis highlights how dirty bombs could cause economic collapse, while modern cyber vulnerabilities and hair-trigger alert statuses between the US and Russia threaten accidental nuclear war with global catastrophic consequences. To mitigate these existential dangers, the organization advocates for ending prompt launch policies, restoring US-Russia dialogue, and accelerating verified disarmament to prevent both state conflict and non-state acquisition of weapons of mass destruction.

  6. 80,000 Hours1h 19m

    #18 - Ofir Reich on using data science to end poverty & the spurious action-inaction distinction

    Ofir Reich, Keiran Harris, Rob Wiblin

    The Center for Effective Global Action at UC Berkeley advances global poverty alleviation through three core initiatives: fostering academic networks, enforcing research transparency to combat the reproducibility crisis, and directing funding for over 70 academics to study poverty. Recent data science projects led by Ophir Reich apply machine learning to detect tax evasion in India, optimize agricultural yields via mobile platforms in Ethiopia and India, and evaluate mobile salary payments for Afghan teachers. These efforts rely on rigorous randomized controlled trials and open data practices, while the organization advises aspiring practitioners to prioritize high-impact roles in established institutions to build the necessary technical capital for long-term effectiveness.

  7. 80,000 Hours55 min

    #16 - Dr Hutchinson on global priorities research & shaping the ideas of intellectuals

    Dr Hutchinson, Michelle Hutchinson, Keiran Harris, Rob Wiblin

    Established at the University of Oxford, the Global Priorities Institute operates as an academic research body dedicated to determining how to maximize good per unit of resources by integrating effective altruism principles with philosophy and economics. Under the leadership of Director Hilary Graves, the institute is currently hiring researchers to develop comparative cause prioritization frameworks and address the limitations of traditional metrics like the QALY. To ensure long-term viability within the university system, the organization structures roles to balance movement-focused agendas with traditional high-status academic publishing, seeking to eventually establish satellite hubs that mirror models like J-PAL.

  8. 80,000 Hours1h 24m

    #15 - Prof Tetlock on how chimps beat Berkeley undergrads and when it’s wise to defer to the wise

    Prof Tetlock, Prof Philip Tetlock, Keiran Harris, Rob Wiblin, Philip Tetlock

    Spanning 35 years of research on over tens of thousands of participants, Philip Tetlock's program utilizes Brier scores to demonstrate that while most experts and hedgehogs perform no better than chance, a specific subset of adaptable "superforecasters" consistently outperforms intelligence analysts through rigorous training and cognitive diversity. These findings inform a new IARPA-sponsored hybrid tournament that pits human-machine teams against each other in quantitative and idiosyncratic domains to identify the most effective forecasting methods. Ultimately, the research underscores the necessity of calibration and open-mindedness over ideological certainty, advocating for structured aggregation systems to mitigate the dangers of overconfident punditry in complex macro-political landscapes.

  9. 80,000 Hours1h 26m

    #14 - Sharon Nunez & Jose Valle on going undercover to expose animal abuse

    Sharon Nunez, Jose Valle, Lewis Bollard, Keiran Harris, Rob Wiblin, Natalie Cargill

    Founded in 2006 by Sharon Nunez and Jose Valle, Animal Equality has evolved from a Spanish volunteer group into a leading international non-profit recognized by Animal Charity Evaluators for three consecutive years. Leveraging investigative journalism, legislative lobbying, and immersive VR technology like iAnimal, the organization currently spares an estimated 4.8 animals per dollar spent through strategies that have secured policy changes affecting millions of farmed animals across multiple continents. Now employing 74 staff members, the group actively seeks specialized talent in data analysis and operations to manage its rapid expansion into new markets like China and Latin America while scaling its annual budget from $200,000 to $3.2 million.

  10. 80,000 Hours53 min

    #13 - Claire Walsh on testing which policies work & how to get governments to listen to the results

    Claire Walsh, Keiran Harris, Rob Wiblin

    The J-PAL Government Partnership Initiative deploys a multi-million dollar fund to sponsor randomized control trials and institutional reforms across twelve countries, directly engaging governments to scale evidence-based interventions like deworming and educational strategies. This approach has influenced policies affecting over 300 million people by translating complex econometric data into actionable one-page summaries and fostering local leadership within regional offices. Furthermore, the initiative facilitates career development for public policy professionals through flexible education programs, emphasizing that institutional strengthening and rigorous empirical analysis are essential for sustainable global equity.

  11. 80,000 Hours1h 30m

    #11 - Dr Spencer Greenberg on speeding up social science 10-fold & why plenty of startups cause harm

    Dr Spencer Greenberg, Keiran Harris, Rob Wiblin

    Spencer Greenberg, a mathematician and founder of initiatives including SparkWave and ClearerThinking.org, advocates for reforming social science research through rigorous methods like data vaulting and leveraging digital tools for large-scale studies. He applies these empirical approaches to developing mental health applications with proven efficacy in reducing depression symptoms while highlighting systemic risks in startups, such as the exploitation of cognitive biases and negative externalities. Greenberg further critiques the effective altruism community for its narrow focus on existential risks and argues that mental health and direct scientific research require significantly more attention alongside urgent work on artificial intelligence safety.

  12. 80,000 Hours1h 14m

    #7 - Julia Galef on making humanity more rational, and why Twitter isn’t all bad

    Julia Galef, Rob Wiblin

    Julia Galef is leading an independent research initiative funded by the Open Philanthropy Project to facilitate dialogues between experts and influential non-experts, aiming to identify specific "cruxes" that drive disagreements on high-impact global issues. Drawing on her background as the host of the *Rationally Speaking* podcast and author of a forthcoming book on judgment, she employs a less rigid "undebate" methodology designed to build epistemic norms rather than force mind changes. The project envisions a future network of approximately 100 key figures who, through structured inquiry, have revised their views on critical long-term risks and policy questions.