Latest Interviews
Showing 631–645 of 822 transcripts.
Clear all filters- Y Combinator50 min
Funding Is an Outcome of Building a Good Business - Porter Braswell of Jopwell
Jopwell, a for-profit career advancement platform founded in 2014 by a former Goldman Sachs trader, connects Black, Latino, Hispanic, and Native American professionals with 44 million qualified underrepresented workers to resolve corporate recruitment pipeline challenges. Leveraging a $12 million funding raise including a Y Combinator investment, the company utilizes a "referral at scale" model that verifies diverse applicant funnels while rejecting non-profit status to operate as a scalable business. Founded on the premise that diversity is a demographic and financial imperative rather than a vague mandate, Jopwell has grown to 35 employees and serves as a data-driven bridge between underrepresented talent and companies explicitly seeking verified, diverse hiring solutions.
- Y Combinator53 min
Researching Psilocybin's Effects on Depression - Dr. Rosalind Watts
Dr. Rosalind Watts, Craig Cannon
Led by Professors Robin Carhart-Harris and David Nutt, a pioneering research initiative successfully demonstrated that high-dose psilocybin can deactivate brain regions linked to negative rumination and offer a "reset" for patients with severe, treatment-resistant depression. Although the study achieved a 100% preference rate for psilocybin over prior treatments among its 20 participants, long-term efficacy remains limited by the absence of formal integration therapy, prompting calls for structured follow-up sessions to sustain behavioral changes. Currently constrained by reliance on single-source funding, the researchers are prioritizing comparative trials against antidepressants while advocating for a holistic therapeutic model that combines preparation, ego-dissolving experiences, and sustained support to address the growing crisis of ineffective psychiatric medication.
- Y Combinator1h 5m
Jeff Clavier and Andrea Zurek - Startup Investor School Day 3
Jeff Clavier, Andrea Zurek, Ali Partovi
Venture capitalist Jeff Clavier and XG Ventures founder Andrea Sterbentz outline a rigorous framework for angel investing that emphasizes an 8–10 year timeline, 10% portfolio allocation of net worth, and strict separation of investment capital from personal liquidity. They advocate for a "super angel" approach featuring time-based diversification, sector specialization, and a 10% ownership target per deal, while simultaneously defining personal branding through consistent thought leadership and operational value beyond mere capital. Both experts stress that successful portfolio construction requires passing on deals lacking total conviction, avoiding direct competition within a portfolio, and maintaining the integrity necessary to build a lasting reputation in the ecosystem.
- Y Combinator58 min
Paul Buchheit - Startup Investor School Day 2
Startup investor Paul Buchheit outlines a strategy prioritizing founders with impossibly ambitious visions and demonstrated resilience over those with polished metrics or low valuations. His approach is validated by massive returns from diverse ventures like Meraki, Twitch, and Cruise, which emerged from ideas that initially appeared flawed or "stupid" to outsiders. Conversely, Buchheit warns that "value investing," pity funding, and slow decision-making consistently lead to losses by missing top-tier opportunities like Airbnb or falling for over-funded failures like Juicero.
- Y Combinator59 min
Carolynn Levy and Kirsty Nathoo - Startup Investor School Day 1
Carolynn Levy, Kirsty Nathoo, Jeff, Sam
The Simple Agreement for Future Equity (SAFE) is a non-debt convertible security designed for early-stage startups to facilitate rapid fundraising through a streamlined five-page document governed by valuation caps or discount rates. While lacking traditional creditor rights like interest or repayment, the instrument converts into preferred stock during priced rounds or liquidity events, with investor returns determined by complex pre-money conversion mechanics and pro rata participation rights. Best practices for execution involve rapid e-signature processing via platforms like Clerky and strict adherence to Y Combinator's handshake protocols to secure high upside potential while avoiding unnecessary legal complexity.
- Y Combinator48 min
The Number One Goal is Getting Started - Avni Patel Thompson of Poppy
Avni Patel Thompson, Craig Cannon
Harvard MBA Avni leveraged her background in pharmaceuticals and international strategy to validate and launch Poppy, a child-care platform, by conducting a four-week manual trial that secured paying users before seeking capital. After three rejections from Y Combinator, she secured funding by demonstrating rapid growth and a scalable vision for global infrastructure, emphasizing that collecting revenue from strangers is essential for true product-market fit. Her journey illustrates a methodology where diverse life experiences, including a failed startup and expatriate living, serve as a "mosaic" of skills to de-risk entrepreneurship and address critical market gaps in modern family support systems.
- Jane Street1h 10m
Shriram Krishnamurthi: Curriculum Design as an Engineering Problem: Lessons from the Field
Shriram Krishnamurthi, Emmanuel Schanzer, Kathi Fisler, Laurie, Askle, James, Shetha, Eric Alata, Kathy, Dharan, Kenny, Yaron, Alice O'Neill, Papert
Bootstrap addresses critical equity and rigor gaps in computer science education by embedding computing concepts directly into mandatory Algebra, Data Science, and Physics curricula rather than relying on scarce specialized teachers or elective courses. This systems-engineering approach utilizes functional programming and a structured "Design Recipe" to scaffold mathematical thinking for all students, successfully mitigating the barriers of after-school programs and traditional silos. Facing scaling challenges due to limited administrative staff and bureaucratic resistance, the organization now prioritizes teacher professional development and is developing middle school modules like Bootstrap Junior to extend this integrated framework to earlier grades.
- Y Combinator59 min
Uncut Interview with Sam Altman on Masters of Scale [Audio]
Sam Altman, Reid Hoffman, Craig Cannon
Y Combinator President Sam Altman reflects on his accidental transition from an 18-year-old student founder to a leader who expanded the accelerator into a global hard-tech hub supporting fields like AI and synthetic biology. Drawing on lessons from his early ventures and investment in Stripe, Altman outlines a philosophy prioritizing intense user engagement, aggressive early-stage scaling, and a frugal culture to mitigate risk and foster organic growth. He emphasizes that successful leadership requires balancing clear vision with formal structure, maintaining humility through historical perspective, and recruiting senior experts to guide first-time CEOs through rapid expansion.
- Milken Institute47 min
U.S. Perspectives on a World in Transition | A Conversation with Thomas J. Barrack
Thomas J. Barrack, Richard Ditizio, Staci Warden
The Milken Institute MENA Summit convened global leaders to address the intersection of medical longevity, pension sustainability, and the critical need for private capital to bridge funding gaps in education and clean energy. During the event, Tom Barrack outlined a shift toward prioritizing total return over yield in an inflationary environment while detailing the Trump administration's strategy of managing conflict to force diplomatic breakthroughs in the Middle East and with China. Barrack further argued that deregulation and a renewed "olive branch" to Palestinians are essential components of the current policy trajectory, predicting that these structural changes will spur entrepreneurship and stabilize regional alliances.
- Milken Institute58 min
FDI in MENA: The Role of Capital Markets and Financial Infrastructure
John Burbank, Sarah Al Suhaimi, Miguel Azevedo, Rayan Fayez, Rishi Kapoor, Frank Kane
Driven by Saudi Arabia's Vision 2030, the market is accelerating global integration through rapid deregulation, the shift to T+2 settlement, and mandatory IFRS adoption to attract foreign capital. With Qualified Foreign Investor registrations doubling to over 120 and MSCI inclusion anticipated to trigger $25 billion in passive inflows, foreign ownership is projected to rise from 1% to double-digit levels within a few years. While challenges remain in judicial reform pace, industry leaders like InvestCorp and the Saudi government expect liquidity to quadruple and corporate governance standards to converge with global benchmarks as the region moves toward a potential unified GCC exchange.
- Milken Institute53 min
African Century: Engaging the Continent's Great Opportunities
Staci Warden, Clare Akamanzi, Joaquim Alberto Chissano, His Excellency Salaheddine Mezouar, Josh Sandler, Salaheddine Mezouar, Veronica Nyamwaya, Miguel, Mark Desario, E, Iyad Malask
African leaders are transitioning from isolated national development to continental integration through the Addis Ababa Summit, which established critical protocols for a free trade area, free movement of people, and unified aviation. This strategy leverages strong regional economic communities and private sector initiatives like the Africa 50 fund to address a $40 billion annual infrastructure deficit and reduce logistics costs that currently inflate product prices by up to 75%. With the continent identified as a top global reformer and possessing a unique demographic advantage, these coordinated efforts aim to mobilize capital markets and skilled labor to unlock massive intra-regional trade potential.
- Y Combinator51 min
Alex Blumberg of Gimlet Media
Gimlet Media acquires podcast talent by prioritizing visionary founders and magnetic hosts with at least 100,000 independent downloads, offering the human capital and marketing infrastructure needed to scale content quality. The company cultivates a non-partisan culture that values empathy and editorial execution, using practical hiring assessments to build teams capable of representing underrepresented voices. Driven by a strategy that leverages YouTube clips for discovery and adapts successful formats like true crime, Gimlet transforms independent audio concepts into sustainable, mainstream productions.
- Y Combinator58 min
Leah Culver of Breaker and Tom Sparks of YC Answer Your Questions About Security and Podcasting
Leah Culver, Tom Sparks, Craig Cannon
This event examines the intersection of government surveillance, device security, and startup culture, highlighting Apple's resistance to backdoors while detailing best practices for developers to protect sensitive data through iOS Keychains and robust multi-factor authentication. Speakers contrast the convenience of biometrics with their permanent compromise risks, advising users to combine passcodes with strong passcode habits to mitigate law enforcement access. The discussion concludes by outlining Breaker's vision to transform podcasting into a serialized content platform and identifying emerging opportunities in IoT security and passive bio-sensing technologies.
- Y Combinator55 min
Tim Urban of Wait But Why
Tim Urban, Andrew Finn, Craig Cannon
Author and researcher Tim Urban leverages his *Wait But Why* blog to catalyze a cultural shift that encourages high-intelligence individuals to pursue careers in artificial intelligence and technology as a strategic response to humanity's imminent existential challenges. By framing the "Page 500" moment—a critical transition where human survival depends on mastering AI safety and overcoming the Fermi paradox's great filter—Urban argues that redirecting top talent toward these fields offers the most effective multiplier for global well-being. This perspective is grounded in a rigorous, multi-source research methodology designed to synthesize complex topics like CRISPR, VR, and space exploration into actionable insights for both creators and future tech workers.
- Milken Institute59 min
U.S. Overview: Big Markets, Big Politics
Philippa Thomas, Jonathan Blair, Ross DeVol, Tony Fratto, Steve Krouskos, William Lee, Trevor Custle, John Jones
A panel of five experts, including Bill Lee of the Milken Institute and Steve Kruskos of EY, assessed the current U.S. economy with high optimism while highlighting a paradox between strong macroeconomic indicators and low public trust. The discussion covered the structural impacts of a $1.5 trillion tax bill, the risks of reduced regulatory burdens, and shifting investment trends driven by Brexit and tightening U.S.-China trade relations. Despite consensus on robust growth potential, speakers warned of underlying vulnerabilities such as income inequality, a slowdown in new business formation, and potential asset price distortions caused by monetary policy uncertainty.