Latest Interviews

Why the most demanding companies entrust their AI to OCI & NVIDA

Romu, Nicolas

NVIDIA and Oracle announced the upcoming arrival of the Blackwell GPU architecture and the GB200 rack-scale system on Oracle Cloud Infrastructure next year, delivering training speeds four times faster than the Hopper generation while introducing the versatile L40S chip by June. To support massive-scale AI workloads, OCI leverages a high-performance interconnect architecture that matches InfiniBand speeds with a 20-40% cost advantage and now hosts enterprise clients like Microsoft for Bing inference. The strategic partnership further expands into sovereign cloud regions in Frankfurt and Madrid to address data privacy concerns, while combining Oracle Database 23c with NVIDIA Inference Microservices to create an end-to-end pipeline for RAG-enabled AI deployment.

How Surbhi Sarna Built A $275M Biotech Company From Nothing

Surbhi Sarna, Ryan Briggs

Serby Serna founded Envision Medical to develop the first FDA-cleared device for early ovarian cancer detection, overcoming significant investor bias by securing seed funding before raising $20 million to advance the technology. The company achieved a $275 million acquisition by Boston Scientific after demonstrating clinical viability, marking a successful exit for Serna who previously faced rejections based on her lack of advanced degrees. Now a Group Partner at Y Combinator, Serna leverages her experience to advocate for biotech founders based on problem-solution fit rather than traditional academic credentials.

AI and our future with Yuval Noah Harari and Mustafa Suleyman

Yuval Noah Harari, Mustafa Suleyman

In a forecast for AI capabilities by 2028, Mustafa Suleiman and Yuval Noah Harari envision frontier models that will autonomously negotiate, execute multi-step actions, and interface with external APIs. While Suleiman frames these tools as engineered systems requiring deliberate constraints to prevent unintended agency, Harari argues that the technology's potential for independent idea creation marks the end of human-dominated history and introduces unique existential risks. To address these challenges, both speakers advocate for a "coalition of the willing" to enforce bans on harmful practices like human-impersonation bots, emphasizing the need for international cooperation over a geopolitical race to the bottom.

Inside El Salvador’s war on crime

Nayib Bukele, Robert Guest

El Salvadorian President Nayib Bukele has implemented a nationwide security strategy that has imprisoned approximately 70,000 individuals, primarily young men detained on circumstantial evidence through group trials that bypass standard due process. This campaign has effectively dismantled democratic checks by purging the judiciary and gagging press coverage, yet it retains approval ratings between 80% and 90% by eliminating gang intimidation in exchange for a police state environment. Minister Gustavo Villatoro explicitly defended these measures as prioritizing citizen safety over human rights protocols while projecting a model where public popularity is sustained through the erosion of civil liberties.

Don't Make These Hiring Mistakes

Harj Taggar, Michael Seibel, Brad Flora

YC partners warn that early-stage startups frequently misapply post-product market fit hiring advice, leading to premature team expansion that depletes runway and accelerates failure. This counterproductive pattern is fueled by founder misconceptions that headcount drives revenue or mimics the org charts of giants like Airbnb and Stripe, despite evidence that successful companies often remained lean for over a year while solving critical product challenges. Instead of scaling before achieving product-market fit, founders are advised to focus on solo execution and only begin aggressive hiring once specific scaling problems arise after validation.

Press freedom: why you should be worried

Daphne Galizia, Avantika Chalkoti, Rana Ayyub, Rebecca Vincent, Matthew, Corinne, Veronika Munk, Sebald Stuhl

Global press freedom is facing severe erosion in both authoritarian regimes and established democracies, evidenced by a rise in journalist murders, the misuse of Strategic Lawsuits Against Public Participation (SLAPPs), and systemic financial bullying. Prominent cases such as the legal persecution of Indian journalist Rana Ayyub and the consolidation of media under Prime Minister Viktor Orbán's government in Hungary illustrate how authorities employ subtle tactics to silence critics. In response to these threats, initiatives like the European Commission's directive to dismiss SLAPPs and the creation of reader-funded outlets like Telex demonstrate emerging strategies to maintain independent reporting despite restricted resources and intimidation.

Climate Resilient Infrastructure: A Conversation with Senator Ed Markey

Ed Markey, Melissa Roberts

Senator Markey frames the current legislative landscape as a historic opportunity to advance the Civilian Climate Corps, a proposed 300,000-person workforce initiative designed to build resilient infrastructure while providing living wages and training for underserved communities. To catalyze these efforts, he advocates for the LIFT Act and a National Climate Bank to fund pre-development projects and leverage private investment, specifically targeting environmental justice regions to achieve a 50% reduction in economy-wide emissions by 2030. Simultaneously, the Senator is maneuvering to secure the final climate provisions within the Build Back Better bill by prioritizing their passage before the State of the Union address, despite facing procedural hurdles and a lack of bipartisan consensus.

What will China do in 2022?

Ed, Zannie

Xi Jinping is positioning himself for a historic third term by centralizing party power through aggressive regulatory crackdowns on the private sector and strict domestic control, which he sustains amidst rising nationalism despite ongoing human rights controversies. This consolidation coincides with a shift toward international assertiveness and a managed geopolitical standoff with the United States, where deep economic interdependence complicates traditional Cold War narratives. As tensions regarding Taiwan remain high with a significant risk of conflict within the next decade, the strategic dilemma for the Biden administration involves balancing firm security guarantees against the potential for destabilizing Asian alliances.

The challenges facing Germany’s new leader

Olaf Scholz, Angela Merkel, Zannie Minton-Beddoes, Tom Nuttall, Jörg Lau

Germany's recent election resulted in a fragmented parliament where the SPD, led by Olaf Scholz, formed a historic three-way coalition with the Greens and the FDP to secure governance. This shift dismantled the traditional two-party dominance, placing smaller parties in pivotal roles while simultaneously reducing the parliamentary influence of extremist factions. The new administration faces immediate challenges in recalibrating foreign policy, particularly in moving away from the Merkel era's engagement strategies with China and managing internal tensions between a Social Democratic chancellor and a Green foreign minister regarding Russia.

Should covid-19 vaccines be mandatory?

Natasha Lodo

Debate over mandatory COVID-19 vaccination policies intensifies as approximately 30% of U.S. adults remain unvaccinated, creating a polarized divide between public health advocates and those defending bodily autonomy. While jurisdictions like Italy and U.S. states such as California have implemented employer mandates and federal testing requirements, the nation lacks a uniform national strategy due to constitutional limitations and stark political opposition. Historical precedents from the smallpox era and mixed results from financial incentive programs suggest that future vaccine mandates will remain highly localized, varying significantly by state politics and legal frameworks.

Is Myanmar a failed state?

Following a February 1st military coup that has resulted in over 780 deaths and 3,800 arrests, the junta has detained de facto leader Aung San Suu Kyi on multiple charges while facing a nascent civil war as the Bamar majority joins ethnic militias in armed resistance. Although international sanctions and diplomatic pressure from the West have targeted senior generals, robust intervention remains blocked by veto power wielded by China and Russia, who prioritize regional infrastructure and strategic arms sales. Consequently, Myanmar risks becoming a failed state plagued by collapsing health systems, uncontrolled drug production, and cross-border refugee flows, while the military inherits a devastated economy despite its current control.

The Future of Market Structure

Kym Arnone, Rick McVey, Annette Nazareth, Aine O'Flynn, Jared Carney, Anya O'Flynn

Moderated by Lightdale CEO Jared Carney, the 2020 Milken Institute Global Conference "Future of Market Structure" panel featured SEC former commissioner Annette Nazareth, BMO Capital Markets' Anya O'Flynn, and Market Access CEO Rick McVeigh to analyze market dynamics during the pandemic. Nazareth highlighted the unexpected robustness of U.S. markets and a surge in retail participation, while McVeigh addressed the paradox of uneven liquidity creation across global fixed income sectors. Together, these leaders evaluated how technology and regulation interacted to maintain investor confidence despite significant economic disruption.

a16z Podcast | Containing the Monolith -- From Microservices to DevOps

Martin Casado, Matt Billmann, Florian Leibert, Karthik Rau

As purchasing power shifts decisively to developers and data scientists, traditional IT operations are being replaced by automated CI/CD pipelines that enable thousands of daily deployments. This transformation compresses the divide between frontend and backend roles while forcing legacy hardware to integrate via microservice wrappers rather than immediate replacement. Organizations must now prioritize speed, observability, and autonomous infrastructure to support high-velocity cycles that range from canary releases to instant rollbacks.

a16z Podcast | The State of Security

Joel de la Garza, Niels Provos, Martin Casado

This event analyzes the critical convergence of cyber, physical, and national security driven by state actors targeting infrastructure destruction rather than mere data theft. Panelists highlight that while hardware-rooted authentication has eliminated phishing success at organizations like Google, the human element remains the primary vulnerability requiring continuous training and strict credential management. Strategic recommendations include adopting hardware security keys, leveraging cloud providers for superior security postures, and utilizing regulatory frameworks like GDPR to shift the industry's incentive model toward proactive risk mitigation.

Talks at GS – The Story of Historically Black Colleges and Universities & Race Relations in America

Stanley Nelson, Jr., Dr. Wayne Frederick, Johnny Taylor, Jr.

Documentary director Stanley Nelson and current Howard University president, the 17th and seventh Black individual to lead the institution, discuss the historical necessity and modern evolution of HBCUs, highlighting their role in transforming legal prohibitions against Black literacy into a premier engine for professional mobility. The conversation details how political pragmatism, exemplified by General Howard's 1867 chartering by President Andrew Johnson and Speaker Paul Ryan's restoration of federal funding cuts, has allowed 101 institutions to produce the majority of Black physicians and dentists despite a contemporary 40-year decline in Black male medical school applications. Ultimately, the speakers argue that maintaining access to these "unbridled opportunities" requires leaders to navigate complex political landscapes without compromising their identity, thereby ensuring HBCUs continue to provide the societal change that began during Reconstruction.