Latest Interviews
Showing 3601–3615 of 4,873 transcripts.
Clear all filters- Goldman Sachs13 min
Dr. Arie Belldegrun, Co-Founder and Executive Chairman, Allogene Therapeutics
Dr. Arie Belldegrun, Dr. Ari Beldegren, Owen Weedy, Steve Rosenberg, David
Dr. Ari Beldergren and Owen Weedy founded Kite Pharma to commercialize NIH-licensed engineered T-cell therapies that overcame industry skepticism regarding the complexity of living drugs. The venture successfully demonstrated the ability to induce complete remission in terminal cancer patients, attracting David from Amgen and catalyzing a sector now comprising roughly 300 companies. Beldergren defines the organization's legacy by its tangible impact on patient survival across lymphoma, bladder cancer, and prostate cancer, positioning clinical improvement as the primary metric for the field's value.
- Goldman Sachs33 min
The Most Rev. Michael Curry, Presiding Bishop of The Episcopal Church
Michael Curry, The Most Rev. Michael Curry
Presiding Bishop Michael Curry, the first African-American to lead the Episcopal Church, navigated profound internal tensions regarding LGBTQ+ rights while uniting the denomination through his 2018 wedding sermon for Prince Harry and Meghan Markle. His tenure emphasized racial justice initiatives in the American South and facilitated a nuanced resolution at Canterbury Cathedral to keep the church within the global Anglican Communion despite theological disagreements. This leadership, rooted in a faith born of ancestral resilience, culminated in a message delivered to two billion viewers that championed love as the essential force for bridging societal divides.
- Goldman Sachs27 min
Wes Moore, CEO of Robin Hood
Former Governor Wes Moore and Robin Hood Foundation CEO outlines how systemic failures in housing, justice, and employment sustain poverty for millions in New York City despite high employment rates. Drawing on his personal journey from homelessness in the Bronx to military service and academic excellence, Moore argues that solving the crisis requires addressing historical inequities like redlining alongside data-driven philanthropy. He challenges the notion of a post-racial society, asserting that explicit policy reforms are essential to dismantle the racial wealth gap and prevent the sixty percent of individuals lifted from poverty from falling back in.
- Goldman Sachs24 min
Lord John Browne, Author of "Make, Think, Imagine: Engineering the Future of Civilization"
Lord John Browne, John Browne, David
Former BP CEO John Browning traces his career from Cambridge physics student to engineer, highlighting how his early fieldwork shaped a strategic shift toward climate accountability and measurable environmental goals despite industry isolation. He argues that oil and gas firms must address Scope 3 emissions while leveraging carbon capture and nuclear fission as near-term solutions, all underpinned by the belief that civilization relies on an engineering platform rather than humanities. Browning further contends that automation will evolve to prioritize human empathy, warns against reactive regulation regarding emerging technologies, and asserts that economies dependent on obsolete industries face extinction rather than redemption.
- Goldman Sachs17 min
Leda Braga, CEO of Systematica Investments
Leida built a career spanning engineering, investment banking, and venture capital before founding Systematica, a quantitative trading firm that currently employs over 100 staff across five offices. The firm is actively converting discretionary strategies into systematic models to improve risk measurement while addressing gender diversity gaps through cultural reforms and flexible trading approaches. Looking ahead, leadership prioritizes succession planning to ensure the institution can operate independently of the founder as the industry navigates challenging market conditions.
- Goldman Sachs30 min
Dr. Mark Esper, US Secretary of Defense
Mark Esper, the 27th U.S. Secretary of Defense, prioritizes reforming the Department of Defense to eliminate bureaucratic inertia while directing strategic focus against China, Russia, and Iran. Under his leadership, the department manages a $738 billion budget and a global force of 2.3 million personnel, balancing military operations like the elimination of Abu Bakr al-Baghdadi with a "maximum pressure" campaign against Tehran and growing great power competition. Esper's leadership philosophy rejects consensus-driven decision-making in favor of soliciting minority views, aiming to leverage military skills for private sector efficiency while maintaining vigilance against authoritarian regimes and cyber threats.
- Milken Institute26 min
A Conversation with Robert Wilkie, Secretary, US Department of Veterans Affairs
The U.S. Department of Veterans Affairs leverages a legacy of six major medical breakthroughs and a 1.2 million patient network to transform veteran care through the transformative Mission Act and integrated digital health systems. By pioneering genomic research, artificial intelligence partnerships with institutions like Stanford, and a military-integrated nursing model, the agency addresses critical challenges such as prostate cancer and a daily suicide toll of 20 veterans. These efforts have elevated the VA's workforce ranking to sixth among federal departments while fostering broad public-private collaborations to expand access and improve long-term outcomes for the 10 million veterans receiving services.
- Goldman Sachs32 min
Rick Atkinson, Author of "The British Are Coming"
Fredrik Logevall is launching *The British Are Coming*, the first volume of a projected three-part history of the American Revolution that recontextualizes the conflict through newly accessed Georgian archives and a detailed examination of George Washington's strategic, rather than tactical, leadership. The narrative challenges traditional assumptions by detailing the brutal reality of the war, including the catastrophic British underestimation of colonial sentiment, the high mortality rates on prison ships, and the pivotal role of Benedict Arnold's delayed campaign in securing French intervention. This 15-year project aims to demonstrate that American independence was a contingent outcome reliant on specific geopolitical circumstances and Washington's unique ability to unify a fractured population under civilian military command.
- Lex Fridman7 min
Bjarne Stroustrup: Simplification is the Key to Reliability and Efficiency in Code
Driven by the critical need for real-time performance in infrastructure like telecommunications and banking, C++ development emphasizes a dual mandate of reliability and efficiency to prevent financial and operational failure. Addressing the "hopeless" challenge of proving absolute safety in complex systems with millions of lines of code, experts advocate for code simplification as the primary strategy to reduce hardware requirements and minimize failure surfaces. This approach prioritizes writing concepts directly in code to ensure maintainability, balancing technical capability with the strict constraint of simplicity to manage the regulatory and testing complexities of modern safety-critical applications.
- Lex Fridman8 min
Sean Carroll: Mindscape Podcast
The podcast host reflects on a strategic shift from reading books to interviewing diverse experts like Wynton Marsalis and Scott Derrickson, emphasizing that cross-disciplinary conversations generate more learning than those within his own field of expertise. By enforcing a policy against conversing with those lacking intellectual good faith and alternating topics to avoid repetition, the host actively cultivates an environment where constructive disagreement, such as that anticipated with philosopher Philip Goff, serves as a core feature rather than a flaw. This approach allows for the exploration of contentious subjects ranging from cognitive dissonance to panpsychism while maintaining a rigorous standard for guest credibility and minimizing backlash from repetitive thematic coverage.
- Lex Fridman9 min
Bjarne Stroustrup: C++ Zero-Overhead Principle and Object-Oriented Programming
The creator of C++ articulates a design philosophy where optimal efficiency is achieved through well-crafted abstractions that strictly adhere to the zero-overhead principle, ensuring no runtime cost compared to equivalent low-level code. This approach prioritizes maintaining a robust static type system and supports a synthesis of object-oriented, functional, and C-style paradigms rather than enforcing a single methodology. While early success relied on the craftsmanship of a small team, the language now addresses complex domains like concurrent programming through interdisciplinary collaboration between algorithmic theory and compiler implementation.
- Lex Fridman1h 47m
Bjarne Stroustrup: C++ | Lex Fridman Podcast #48
Bjarne Stroustrup, Lex Fridman
Bjorn Strøistrup, the creator of C++, asserts that the language remains the foundational layer for critical back-end systems and safety-critical applications like autonomous vehicles due to its "Zero Overhead Principle" and deterministic resource management via RAII. He advocates for a multi-paradigm approach where professional programmers master diverse languages to combine the efficiency of C++ with the abstractions of functional and dynamic styles, while emphasizing that code simplification and static analysis are essential for system reliability. Despite the rise of new tools and languages, Strøistrup maintains that C++'s rigorous standardization and ability to express intent without runtime penalties ensure its continued dominance in high-performance engineering domains.
- Lex Fridman19 min
Sean Carroll: Many-Worlds Interpretation of Quantum Mechanics
Speaker advocates for Hugh Everett III's Many Worlds Interpretation as the most mathematically parsimonious quantum framework, arguing that measurement arises from universal wave function entanglement rather than fundamental observer influence. This perspective relies on a finite Hilbert space of $10^{10^{122}}$ states to define a limit on universal branching while ensuring strict energy conservation through unitary evolution. Ultimately, the interpretation is preferred over hidden variables, spontaneous collapse, or epistemic models because its lack of classical baggage allows seamless integration with quantum gravity and holographic theories.
- Goldman Sachs30 min
Former Ambassador Susan Rice, Author of "Tough Love"
Former National Security Advisor Condoleezza Rice discusses the strategic implications of al-Baghdadi's death, the trauma of the Benghazi crisis, and her leadership of the Obama administration's all-female National Security Council team. She details how her childhood resilience and early career decisions shaped a management style that balanced aggressive security actions with diplomatic nuance. The discussion concludes with her assessment of U.S.-China relations, where she warns that America risks losing a long-term strategic endurance contest against Beijing without a radical shift in American resolve.
- Goldman Sachs24 min
Kirsten Green, Founding Partner of Forerunner Ventures
Forerunner Ventures founder Kirsten Green leveraged early wins like Dollar Shave Club and earlyjoints.com to build a strategy focused on identifying founders who address consumer friction through digital agility and ethical branding. Concurrently, she co-founded All Raise to combat systemic disparities in the industry by increasing the representation of female general partners and supporting diverse entrepreneurs through mentorship and capital allocation advocacy. Green's approach emphasizes operational transparency and the necessity of adapting to a saturated market by backing leaders who can compel stakeholders to join their vision before securing funding.