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E85: SBF's crypto bailout, Zendesk sells for ~$10B, buyout targets, US diplomacy, AlphaFold & more

SBF, Chamath, Calacanis, Friedberg, David Sacks

A British Virgin Islands court ordered the liquidation of Three Arrows Capital, triggering a cascade of defaults and bailouts involving Sam Bankman-Fried that exposed systemic risks in unregulated crypto markets and spurred predictions of aggressive regulatory crackdowns. Simultaneously, the acquisition of Zendesk for $10.2 billion marks a pivotal shift in the software sector where private equity investors prioritize free cash flow and profitability over the previous era of loss-led growth. On the macro and scientific front, economists forecast a prolonged recession driven by inflation and geopolitical instability, while researchers achieved a breakthrough in modeling the nuclear pore complex using AlphaFold, offering new pathways for treating severe diseases.