Conference Presentation, Fireside Chat, Panel
Longevity Lab: Can You Live to 100? | Global Conference 2024
Milken InstituteAllison Aubrey, James Bethell, Dan Buettner, Peter Diamandis, Kristen Fortney, Lloyd Minor
- Northwestern University is developing a new longevity study and Longevity Lab to identify interventions that slow aging rates.
- Dan Buettner projects life expectancy will increase by approximately two years per decade based on trends observed since 1840, while Blue Zones communities currently live an extra 10 years at middle age.
- Kristen Fortney predicts the average human lifespan will reach 100 years through scientific innovation and new medicines that prioritize healthy living over mere longevity.
- Dr. Peter Diamandis forecasts the current decade will see a convergence of capital, AI, quantum technology, advanced diagnostics, and therapeutics that propel the longevity field toward "longevity escape velocity," where science adds more than a decade to life for every decade lived.
- Dr. Peter Diamandis expects the XPRIZE Healthspan competition to conclude by 2030 with a solution capable of reversing functional loss by at least 10 years, aiming for a 20-year reversal.
- Dr. Peter Diamandis predicts that within 10 to 20 years, people will utilize epigenetic reprogramming gene therapies or drugs, noting that animal and primate data support resetting the epigenome to a younger age.
- Kristen Fortney anticipates that by 20 years, the majority of people will take anti-aging drugs due to potent biological levers and a robust pipeline of upcoming treatments.
- Dan Buettner predicts that applying policies, nudges, and lifestyle characteristics in American cities for five years will reduce BMI, lower healthcare costs, and increase life expectancy.
- Dan Buettner asserts that consuming approximately 80 black beans daily is associated with four extra years of life expectancy, while eating 15 to 30 walnuts daily correlates with three extra years.
- Kristen Fortney expects results from a clinical trial combining her compound with GLP-1 agonists within a year and estimates the LEAD program clinical trials will take about a year and a half.
- Kristen Fortney expects rapamycin studies to launch this year, with the drug likely to be pro-longevity based on animal data, while noting the senolytic drug industry remains nascent.
- Kristen Fortney projects that weight loss therapies will shift toward well-tolerated, small-molecule oral medicines used chronically over several years to maintain healthy body composition.
- Kristen Fortney expects Azeloprag to mimic exercise effects, improve body composition, and potentially increase longevity and physical function in aging humans.
- Kristen Fortney anticipates the establishment of forward-looking biobanks in the U.S., Norway, and Estonia that collect samples from middle-aged individuals to track health for the remainder of their lives.
- Dr. Lloyd Minor predicts generative AI will transform fundamental biological discovery, drug discovery processes, and clinical trial designs within this decade.
- Dr. Lloyd Minor plans to apply greater scientific and educational rigor to understanding social, behavioral, and environmental health determinants to develop affirmative interventions.
- Dr. Lloyd Minor foresees advances in cancer therapy approaches being adapted to create better predictive measures and early interventions to prevent disease entirely.
- Lord James Bethel predicts hospitals will close as people prefer community-based treatment, with the healthy choice becoming the easiest option and taxes supporting prevention measures.
- Lord James Bethel expects that matching policies to support families, communities, and gardens will be crucial for longevity, necessitating a rebalancing of the NHS budget.
- Lord James Bethel anticipates that future doctors will prescribe holistic care including food distribution, such as bags of carrots, to encourage confident families.
- Lord James Bethel believes personal habits and societal environments must be addressed for therapeutics to successfully transform opportunities for longer life.
- Dan Buettner warns that while major breakthroughs will occur, they must address the entire system to avoid creating larger healthcare problems through incomplete drug solutions.
- Dr. Peter Diamandis warns that early detection is crucial as 70% of heart attacks have no precedent and cancer must be identified before it is too late.
- Dr. Lloyd Minor expects that therapies like bone marrow transplantation will be repeatedly refined to predict, prevent, or forestall disease altogether.
- Dan Buettner warns against creating a bigger healthcare problem with drugs that do not address the entire system.