Latest Interviews
Showing 31–40 of 40 transcripts.
Clear all filters- a16z27 min
CRISPR 2.0 and the Future of Gene Therapies
The gene therapy sector is undergoing a paradigm shift from simple transgene addition to precise CRISPR-based editing, driven by recent FDA approvals and a pipeline projecting dozens of Phase 3 trials this year. Despite significant progress in developing base editors and expanding delivery vectors, the industry faces critical bottlenecks in manufacturing scalability and achieving organ-specific targeting without immunogenicity. Successful organizations are distinguishing themselves by combining rigorous engineering mindsets with interdisciplinary teams to optimize modalities and automate production for a future of millions of patients.
- Y Combinator29 min
Carolynn Levy - Modern Startup Funding
Early-stage financing has shifted from complex, costly Series A preferred stock rounds to streamlined convertible securities like Y Combinator's SAFE, which allow founders to raise capital rapidly without immediate legal counsel. While these instruments facilitate frequent small checks and faster closings, they introduce challenges such as tracking dilution until conversion and potential administrative burdens from party rounds with numerous angels. Ultimately, founders must balance the efficiency of modern templates against specific deal structures and regional investor preferences to avoid corner cases where funding fails to convert into equity.
- a16z23 min
a16z Podcast | An Open Source Business Model That Works
DigitalOcean pioneers an "open source as a service" model that abstracts the operational complexity of virtualization and tools like KVM, offering developers and enterprises a utility-based infrastructure with predictable total costs of ownership. This approach differentiates the platform by prioritizing interface simplicity and automated provisioning to help users scale workloads in seconds, effectively replacing traditional capital expenditures with variable, cent-per-hour pricing. Industry consensus emerging from the discussion highlights containers and flash storage as the near-term technological foundations for this efficiency, ensuring supply aligns with variable demand while maintaining hypervisor support for multi-OS compatibility.
- Y Combinator26 min
Geoff Ralston and Adora Cheung Discuss Startup School
Geoff Ralston, Adora Cheung, Craig, Jeff
Startup School is a 10-week Stanford-taught online program led by YC partners and executives Paul Graham, Sam Altman, and Michael Seibel, designed to lower barriers for early-stage founders globally. The course offers two participation tracks featuring live lectures, expert advice from volunteer founders, and access to exclusive partner deals, while incentivizing serious commitment through $10,000 equity-free grants awarded to 100 completing companies. Building on last year's success where 38 graduates entered the YC accelerator, the initiative aims to maximize global innovation by fostering accountability and providing capital to prevent promising startups from failing due to early funding gaps.
- Goldman Sachs28 min
David Solomon Formally Announced as Lloyd Blankfein’s Successor
David Solomon, Lloyd Blankfein
Goldman Sachs announced that CEO and Chairman Lloyd Blankfein will retire at year-end, with David Solomon assuming immediate leadership of both roles as the firm enters a new strategic chapter. The transition coincides with a period of strong performance across investment banking and investment management, while Solomon pledged to uphold the firm's partnership culture and drive digital innovation through its Marcus and Clarity Money initiatives. With the firm aiming for its best fiscal year ever under the outgoing leadership, the move is presented as an evolution of the 149-year-old legacy designed to maintain competitive advantage in a changing regulatory and market landscape.
- Goldman Sachs30 min
Chris Hughes on Founding Facebook and Fighting Inequality
Former Facebook co-founder Chris Hughes is launching the "Fair Shot" initiative to provide $500 monthly payments to 60 million working adults earning under $50,000 annually, aiming to eradicate poverty without dismantling existing social safety nets. Funded by a 50% marginal tax rate on the targeted demographic and capital gains, this policy shifts the economic paradigm from charity to a guaranteed income floor designed to counteract the destabilizing effects of automation and income inequality. Simultaneously, Hughes leverages his history as a tech executive to advocate for strict data rights legislation and a user-owned data dividend, positioning his campaign as a dual front against both corporate monopolies and systemic poverty.
- Goldman Sachs21 min
Remarks by Warren Buffett
Warren Buffett, John F.W. Rogers, Kevin McCarthy, Tyler Perry, Danny Meyer, Sarah Kauss, Wilbur L. Ross, Sara Blakely, Michael Bloomberg, Gina Raimondo, Rick Snyder, Marco Rubio, Lloyd Blankfein, Richard Branson
At LaGuardia Community College, an 87-year-old speaker honored the resilience of diverse students by recounting the historic rises of Rose Blumpkin and Jack Taylor, who built billion-dollar empires from minimal capital through relentless customer service. The presentation detailed how Blumpkin grew a Nebraska furniture market to $1.5 billion in annual revenue and how Taylor transformed a small car lease operation into Enterprise Rent-A-Car, surpassing all major competitors by prioritizing experience over price. Ultimately, the address argued that sustainable growth depends on cultivating a culture where employees are valued and customers are delighted, urging the graduating class to prioritize self-improvement and associate with superior role models.
- Milken Institute34 min
A Conversation with PepsiCo CEO Indra Nooyi
Indra Nooyi, Michael Milken, Andrew, Mike
PepsiCo CEO Indra Nooyi transformed the beverage and snack giant through "Performance with Purpose," a strategy that integrated social and environmental sustainability into core operations while shifting the revenue portfolio toward healthier product lines. This cultural overhaul was driven by scientific leadership under Chief Scientific Officer Dr. Mahmood Khan and reinforced by tying executive compensation to specific nutritional and environmental goals. Nooyi further extended the company's impact by forging partnerships with healthcare institutions to improve access for underserved veterans and advocating for systemic policy changes to address chronic disease and nutritional equity.
- Goldman Sachs23 min
Ray Kelly, Former NYPD Commissioner: Talks at GS Session Highlights
Former NYPD Commissioner Raymond Kelly, the first officer to rise from a cadet to the agency's top leadership, details his tenure's establishment of the first municipal counterterrorism bureau and the surveillance of major events like the 2010 Times Square bombing attempt. Kelly critiques a 2011 ruling on racial profiling as evidentiary flawed and warns that current oversight measures and the refusal to appeal could shift policing from proactive crime prevention to reactive responses, a strategy he links to a reduction of 9,300 murders over two decades. With ISIS cited as an escalating global threat, Kelly advocates for the continued use of data-driven security initiatives like the Lower Manhattan Security Initiative while balancing privacy concerns through automatic data deletion protocols.
- Milken Institute33 min
Best-Performing Cities Index 2014 - Press Conference
Ross Duvall, Jim, Manoli Ratacunga, Armin Bedrosian, David Klesch, Kish Rajan, Larry
The 2014 Milken Institute Metro Index identified San Francisco as the top U.S. economic performer, driven by a technology sector that accounts for 45% of metro job growth and offers average wages of $160,000. While five Texas metros and cities like Provo, Utah, also ranked highly due to energy and job creation, the report noted that U.S. employment has fully recovered from the recession alongside a historic surge in oil production. Mayor Ed Lee responded by outlining aggressive strategies to expand the local economy through housing initiatives targeting 30,000 new units and diversifying sectors beyond technology to include biotech and manufacturing.