Y Combinator
Showing 1–15 of 854 transcripts.
- 43 min
How Jeetu Patel Runs Cisco Like the World’s Largest Startup
Cisco CEO Jitu Patel is repositioning the company as a full-stack infrastructure provider for the AI era, driving a rapid business expansion that reached $9 billion in orders by the recent fiscal year. To support this growth and address unprecedented network demands from AI agents, Patel enforces a mandatory "go all-in" AI adoption policy while restructuring leadership to blend seasoned operators with external experts and startup founders. This "wartime" operational strategy aims to secure the supply chain and security of a rapidly scaling market, positioning Cisco to capture the next phase of artificial intelligence integration across silicon, photonics, and software.
- 1h 21m
What If We Stopped Using GPUs? | YC Paper Club
This event examines the stagnation of FLOPS-based efficiency in current AI hardware and proposes alternative architectures that align with biological constraints, such as feed-forward pathways and the elimination of backpropagation's weight transport problem. Speakers detail emerging solutions including zero-order optimization techniques like SPSA combined with the Sharded Optimization Mixture of Assemblies strategy, alongside hardware innovations in optical computing and neuromorphic systems that prioritize energy scaling and memory-compute co-location. The discussion culminates in a case study on biological computing, specifically the collaboration with Cortical Labs to train human brain cell cultures to play *Doom*, illustrating a novel paradigm where intelligent behavior emerges from entropy minimization in a distributed, non-digital substrate.
- 30 min
New LLMs Are Unlocking Robot-Use Agents
Francois, Hanmei, Vincent, Jay
Frontier researchers and startups like Waddle Labs are advancing a paradigm shift toward general-purpose "robot use agents" that leverage coding-based policies and cross-modal data to perform complex physical tasks without specialized fine-tuning. By applying the "Bitter Lesson" principle to consolidate diverse datasets, these systems utilize in-context learning and memory consolidation architectures to rapidly adapt to new environments, with current demonstrations successfully executing multi-step manipulation challenges. Industry projections indicate that as latency decreases and internal world representations converge, economically viable, general-purpose robots capable of performing competent human-like tasks will emerge within two years.
- 36 min
Startups Are Moving From Bits to Atoms
Recent YC batches have witnessed a hard tech resurgence, with the physical sector share tripling to 20% alongside a historic 1-in-6 PhD founder rate driven by AI acceleration and macroeconomic shifts in defense and space. Concurrently, the software landscape has pivoted toward revenue-generating agentic workflows and solo founders, as AI tools enable single individuals to execute complex full-stack operations and experienced founders to manage autonomous coding teams. These trends collectively signal a fundamental shift where advanced physical intelligence, specialized silicon, and autonomous agents are redefining startup viability and scaling strategies.
- 13 min
How To Get Better At Outbound Sales
Founder-led sales strategies prioritize executing at least 100 manual outreach attempts to validate messaging and targeting before attempting automation, ensuring high conversion rates through rigorous prospect research and job title verification. This approach relies on constructing problem-centric, peer-to-peer communication while leveraging customer feedback to build credibility and optimize LinkedIn profiles for maximum trust. Successful execution requires strict operational discipline, including daily time-blocking for consistent volume and a systematic debugging framework that iterates through deliverability, content, and market fit until a viable reply rate of two to three per hundred is achieved.
- 1h 0m
Self-Improving Harnesses, Local Personal AI And YC's Agent For Work | YC Paper Club
Seth Karten, Jon Saad-Falcon, Josh France, Regan Bell
YC Harness Club researchers demonstrate that "self-improving harnesses" capable of modifying their own code and memory have driven Arc AGI success rates from 30% to 100%, surpassing standard prompt engineering by leveraging recursive learning architectures. Presentations by Seth and John Sad Falcone detail specific implementations like Prime Agent's multi-tier context management and OpenJarvis's local on-device stack, which collectively achieve frontier-level performance while reducing costs by 800x and enabling autonomous long-horizon research. Furthermore, the QM project establishes a centralized cloud-hosted framework with dynamic sandboxing and fine-grained permissions, addressing critical challenges in system-wide coordination and data security for scalable multi-agent deployment.
- 57 min
Open Models Are Collapsing The Cost Of AI
Driven by cost efficiency and customization needs, enterprises are increasingly adopting open AI models, with major corporations like AT&T shifting significant token consumption away from proprietary systems toward flexible, locally deployable solutions. Ollama has emerged as a critical orchestration layer for this ecosystem, supporting 85% of Fortune 500 companies and facilitating a hybrid deployment strategy that balances local hardware capabilities with cloud-based inference for complex tasks. This market shift positions open models to handle the majority of daily enterprise workflows, reducing reliance on expensive frontier closed models while navigating geopolitical security concerns through rigorous supply chain verification and secure hosting environments.
- 21 min
Paul Graham On Startups, Ambition, and Great Founders
Paul Graham delivered his 47th Y Combinator batch talk, highlighting a shift toward high-seriousness ventures in logistics and cancer research while defining founder ambition through the "formidable" archetype of those who consistently achieve their goals. Graham analyzed the current AI landscape, noting its uneven "jagged frontier" and the economic reality that token costs now eclipse salaries despite rapid price declines. He concluded that Y Combinator's ecosystem remains vital for peer collaboration and that the next trillion-dollar company will emerge not from a specific idea but from formidable founders capable of adapting to shifting market conditions.
- 15 min
The World’s Largest Electric Aircraft Just Flew
Gustaf Alströmer, Anders Forslund, Clara
Heart Aerospace successfully flight-tested the world's largest electric airplane, a 100-foot wingspan aircraft capable of carrying 36 passengers on short-haul routes with minimal operating costs. Led by CEO Anders Forslund and co-founder Clara, the Los Angeles-based team utilized a hybrid configuration to achieve a 500-mile range while significantly reducing maintenance and noise through the replacement of traditional jet engines with electric motors. This clean-sheet design, which marks the first new American airliner in 18 years, aims to replace inefficient regional jets by leveraging existing airport infrastructure and capitalizing on current advancements in battery technology.
- 1h 0m
Max Junestrand: You Need The Willingness To Learn Faster Than Anyone Else
Max Junestrand, Gustav Omstrammer
Legora has scaled from three Swedish engineers to over 750 employees, generating $100 million in annual recurring revenue while deploying an agentic AI operating system that now serves three percent of the world's lawyers. Following a strategic pivot after a $35 million funding round revealed revenue lagged behind interest costs, the company shifted focus from growth velocity to product-market fit by freezing sales and transitioning to proactive, autonomous agents. Founded by Max, August, and Sigge, the firm differentiates itself through a high-intensity culture designed to overcome Scandinavian humility, recently securing talent at a 23-year-old salesperson who generated over $10 million without prior industry experience.
- 53 min
Going In Deep On Data | YC Paper Club
Francois Chaubard, Vincent Sunn Chen, Volo Kuleshov, Shayne Longpre
Industry experts from Snorkel, Inception Labs, and MIT articulate a paradigm shift where data has evolved from a passive resource into a $100 billion sector requiring complex product craftsmanship and continuous expert supervision. Presentations detailed breakthroughs such as Snorkel's Senior SWE-bench with validation agents, Inception's Mercury 2 diffusion model achieving 1,000+ tokens per second, and novel cross-lingual scaling laws that optimize low-resource language performance. These developments collectively redefine the production frontier by demonstrating that architectural advances alone are insufficient without scalable data programming and domain-specific synthetic environments to resolve real-world distribution gaps.
- 40 min
Michael Kratsios: Inside the White House's AI Strategy
White House OSTP Director Michael Kratos advocates for an AI strategy that prioritizes open-weight models and rejects rigid regulatory thresholds, emphasizing a unified national standard to prevent incumbents from stifling startups. Through the report *A New Golden Age for Science*, the administration proposes shifting federal research funding toward private sector leadership while accelerating scientific breakthroughs via autonomous cloud labs and rapid-grant mechanisms. This approach complements President Trump's executive order on quantum computing and a broader "born free" philosophy that aims to remove barriers for digital technologies while carefully managing specific physical risks.
- 52 min
Susan Kare: How I Designed the Original Apple Mac Icons
Iconographer Susan Kerr recounts her pivotal role in shaping early Macintosh interfaces, from designing the "Chicago" font to creating iconic symbols like the "Happy Mac" boot screen under strict pixel constraints. Drawing on her experiences at Apple, Microsoft, and Facebook, she advocates for minimalist design principles that prioritize meaningful metaphors over product-specific imagery to ensure universality and longevity. Her career highlights how simple, salient details and strict limitations can foster creativity, ultimately defining the visual language of modern computing interfaces.
- 58 min
Chelsea Finn: This is the State of the Art in Robotics
Physical Intelligence has advanced its PI-07 foundation model to achieve general-purpose physical AI capable of zero-shot generalization across diverse appliances and robots without task-specific retraining. By integrating multi-timescale memory and optimized reinforcement learning strategies, the organization significantly improves task throughput and reliability for complex manipulation scenarios like kitchen workflows. Currently deployed by YC-backed companies for real-world applications, these models represent a shift toward "out-of-the-box" generalist agents that can operate autonomously in unstructured environments.
- 15 min
Circleback CEO Ali Haghani: Why Your Company Should Be Recording More Meetings
Circleback, a YC Winter 24 batch company, functions as an AI-driven "company brain" that records, transcribes, and orchestrates team conversations to automatically generate notes and update CRM systems. Founder Ali employs the platform to manage recruitment pipelines and partner relationships while utilizing a specialized workflow that combines AI-generated code with strategic oversight to accelerate product development. The organization is simultaneously establishing rigorous governance protocols for autonomous agents and shifting its operational focus toward high-leverage decision-making as it transitions from manual coding to AI orchestration.