Latest Interviews
Showing 451–465 of 1,563 transcripts.
Clear all filters- Goldman Sachs1h 4m
Dr. Michael Mina of the Harvard T.H. Chan School of Public Health
Michael Mina, Salveen Richter, Terence Flynn, Solving Richter
Dr. Mina outlines the novel coronavirus as a highly transmissible pathogen with reduced virulence that threatens global pandemic spread through widespread asymptomatic transmission and unstable immunity patterns. Current U.S. diagnostics face critical supply chain bottlenecks that necessitate triage-based testing, while therapeutic strategies rely on supportive care and experimental antivirals like Remdesivir alongside accelerating vaccine development. The speaker predicts that aggressive social distancing can suppress transmission to protect healthcare capacity, though long-term management will likely require balancing economic needs with endemic cycles rather than aiming for total eradication.
- a16z45 min
How Gaming is Changing the Media Landscape
This event analyzes the transformative growth of the global games industry, which now surpasses traditional media in revenue and audience size by leveraging real-time 3D rendering and a shift toward "Games as a Service" business models. It details how major technology firms like Unity and Tencent are driving vertical integration in esports and expanding into non-gaming sectors such as automotive and architecture through photorealistic digital twins. The discussion further addresses critical technical challenges in cloud gaming latency and forecasts a future where AI, 5G, and cross-platform ecosystems create persistent virtual economies accessible to billions of users worldwide.
- Milken Institute1h 0m
New Pathways to Neuroscience Breakthroughs
Rick Berke, Cara Altimus, Jeffrey Borenstein, Niranjan Bose, Johannes Streffer, Mike Belville, David Mongeau, Janet Knupp, Jing Lu, Ian Kramer, Anna McAllister
A panel of experts highlighted the critical gap in preventing and treating brain disorders despite projections that dementia cases will double over the next three decades. To address historical stagnation and corporate retreat, the discussion emphasized a strategic pivot toward diverse biological hypotheses, early biomarker detection, and philanthropic de-risking led by organizations like the Gates Foundation. This approach aims to overcome diagnostic delays and therapeutic failures by integrating real-world data, stem cell modeling, and patient-centric outcomes to accelerate the development of rapid-acting treatments.
- Milken Institute1h 1m
A Journey to the Cutting Edge of Bioscience: Cancer as a Case Study
Margaret Anderson, Greg Friberg, Douglas Lowy, Fouad Namouni, Ellen Sigal, Nikhil Wagle, Angie Wilson, Sebastian Hermelin
Advancing from a generalized approach to highly personalized medicine, oncology has achieved unprecedented five-year survival rates for metastatic melanoma and long-term remission in lung cancer through immunotherapy and combination strategies. Despite these clinical successes, the sector faces significant hurdles including low clinical trial enrollment in community settings, fragmented electronic health record data, and ethical barriers to information sharing. To overcome these obstacles, stakeholders are leveraging artificial intelligence, patient-centered initiatives like "Count Me In," and predictive modeling to integrate community biospecimens and accelerate the development of functional cures.
- Y Combinator56 min
YC SUS: Eric Migicovsky & Dalton Caldwell discuss pivoting & pitching
Eric Migicovsky, Dalton Caldwell, Eric Majerjkowski, Rick Viscomi
This discussion outlines critical strategies for startup founders, emphasizing that pivots should be driven by a complete lack of traction and validated through concrete customer payments rather than theoretical debates. It further details how to effectively apply to Y Combinator by prioritizing clarity, avoid common pitfalls like over-relying on patents, and ensure sustainable unit economics by focusing on retention and revenue. Ultimately, the guidance stresses that success relies on building genuine product-market fit and maintaining financial flexibility to adapt quickly to external shocks.
- Jane Street58 min
Matt Might: The Algorithm for Precision Medicine
Matt Mite, director of the Hugh Call Precision Medicine Institute at UAB, leverages computational optimization and a knowledge graph of 30 million abstracts to derive actionable precision medicine strategies for patients with undiagnosed genetic disorders. His approach, exemplified by the successful treatment of his son Bertrand's NGLY1 deficiency and the identification of Prevacid for ion channel epilepsies, prioritizes logical mechanism proofs to overcome physician skepticism and legal liability. Through an undergraduate-led workflow and the "All of Us" initiative, Mite's institute continues to transform complex genomic data into targeted interventions, from drug repurposing to novel metabolic pathways, asserting that scientific experimentation always yields actionable solutions.
- Y Combinator1h 0m
YC SUS: Gustaf Alströmer and Eric Migicovsky discuss growth tactics
Gustaf Alströmer, Eric Migicovsky, Gustav
This comprehensive analysis outlines critical strategies for early-stage startups, emphasizing that charging users immediately is essential for validating product-market fit and sustaining growth. Founders are advised to prioritize direct customer engagement and curated supply acquisition while leveraging predictive retention metrics and substantial referral incentives to drive scalable adoption. The guidance further details how to navigate market education through targeted SEO and social proof, ensuring that monetization models align with user value rather than relying on unsustainable advertising revenue.
- Milken Institute59 min
Venture Capital: The Rise of the Rest
Fahad AlSharekh, Ibrahim Ajami, Avi Eyal, Sarah Kunst, Jack Selby, Pule Taukobong
Leading venture capitalists from the Middle East and Africa, including representatives from Mubadala, Entree Capital, and Teal Capital, discuss a surge in regional capital inflows and the shift toward deep-tech sectors like AI and semiconductors. Despite persistent talent shortages and infrastructure gaps, panelists identify emerging local funds as critical gatekeepers that will validate startups before attracting tier-one international follow-on capital. Strategic partnerships are forming to foster founder-centric cultures and build indigenous expertise, positioning these frontier markets for potential growth that may soon outpace traditional U.S. and European hubs.
- Milken Institute54 min
The Future of Banking
Dan Murphy, Elissar Farah Antonios, Steve Jacobs, Sunil Kaushal
Industry experts at the "Future of Banking" summit concluded that traditional financial institutions must integrate with fintechs and Big Tech rivals to survive a shift from product silos to data-driven platforms. Case studies from BTG Pactual and Citi illustrated how strategies like tokenization, internal innovation challenges, and leadership exposure to tech hubs can drive market growth and cultural agility. Despite these disruptions, the event emphasized that incumbent banks retain a significant valuation advantage over digital-native competitors while navigating regulatory hurdles and the need for massive cybersecurity investment.
- Milken Institute1h 11m
Morning Program - Opportunity in the Middle East: A Road Less Traveled
Michael Clowden, John Riccolta, Mina al-Arabi, Khaled El-Romehi, Mohamed El-Ardi, Abdullah Zamil
At the Milken Institute MIA Summit in Abu Dhabi, regional leaders and experts from the UAE, Bahrain, and Saudi Arabia outlined a collective strategic pivot from hydrocarbon dependence toward diversified, knowledge-based economies driven by demographic youth bulges and technological innovation. Key speakers highlighted specific success models, such as Bahrain's telecommunications deregulation and Saudi Arabia's Vision 2030 initiatives like NEOM, while emphasizing the critical need for robust intellectual property laws and regulatory frameworks to attract foreign direct investment. The discussions concluded that navigating fiscal constraints and geopolitical volatility requires governments to transition from primary employers to regulators, fostering private sector competition to absorb the growing workforce and achieve long-term stability.
- Milken Institute56 min
A Conversation with Leon Black
Founded by Leon Black three decades ago, Apollo Global Management now directs $350 billion in assets across 18 global offices using a diversified "fund for all seasons" strategy that spans private equity, private credit, insurance, and real assets. The firm distinguishes itself by targeting an average acquisition multiple of 6x EBITDA and prioritizing complexity arbitrage in corporate carve-outs and distressed scenarios, while shifting 80% of capital into long-duration structures to mitigate fundraising pressure. Facing a market where public valuations discourage long-term planning, Apollo is actively deploying capital into public-to-private transactions and emerging sectors like aviation finance with the goal of generating 8–10% returns in credit platforms over the coming years.
- Milken Institute56 min
Shifting Tides: A Macroeconomic Outlook
John Defterios, Virginie Afota, Roxanne Davies, Robert A. Gillam, Michael Metcalfe, Alireza Zaimi, Rob, Virginia, Ella Reyes, Brigitte
This macroeconomic forum analyzed how central bank liquidity and media narratives are currently driving asset rallies while emerging markets like China face GDP contraction from trade tensions and viral shocks. Experts contrasted these short-term credit risks with long-term structural themes, including a projected 20% global population growth and the strategic evolution of sovereign wealth funds in the Middle East toward diversified infrastructure and ESG integration. The panel concluded that despite volatile oil prices and inflation concerns, institutional investors are increasingly shifting from tactical trading to decade-long horizons focused on demographic shifts, technological disruption, and sustainable resource allocation in Asia and emerging economies.
- Milken Institute1h 2m
Is Crypto Finally Growing Up?
Staci Warden, Michael Gronager, Navin Gupta, George Kikvadze, Simon Seojoon Kim, Mike Novogratz
Moderated by Stacey Worden, a panel of industry leaders including Mike Novogratz and George Kikvadze confirmed the cryptocurrency sector's evolution from a speculative frontier to a regulated, institutional-grade asset class. The discussion highlighted Bitcoin's role as a macro hedge against fiat debasement while outlining how enterprise solutions like Ripple are driving mass adoption in Asia and how blockchain traceability effectively combats illicit finance. Looking ahead, the group projected that infrastructure maturation over the next five years will trigger a global economic transformation comparable to the post-1999 internet boom, with billions of users entering the ecosystem through decentralized finance and device-to-device interactions.
- Milken Institute50 min
Life After Sport - What Do Elite Atheltes Do Next?
Sarah Sandler, Khaled Al-Mahri, Didier Drogba, Clarence Seedorf, Vladimir Kilichkov
Hosted by the Milken Institute in Abu Dhabi, an all-star panel featuring Didier Drogba, Nicolas Anelka, Clarence Seedorf, and Vladimir Kilichkov discussed strategic transitions from elite athletics to sustainable business and leadership roles under the moderation of Khaled Al-Mahri. The distinguished athletes shared specific insights on mental resilience, injury prevention, and long-term planning, while highlighting critical gaps in African football infrastructure and the broader socio-political power of the sport. Their collective dialogue emphasized that enduring success in both sports and commerce requires a foundational philosophy of "Challenge Management," coordinated efforts among strategic partners, and a shift toward proactive, future-oriented governance.
- Jane Street1h 24m
Steve Lee: State of the Shell: PowerShell7
The PowerShell team announced a strategic shift where Windows PowerShell 5.1 is now maintenance-only, while the primary focus moves to PowerShell 7 as a cross-platform Long-Term Servicing release aligned with the .NET yearly cycle. Significant technical improvements include the introduction of null propagation, parallel processing capabilities, and a new module management system designed to replace the deprecated v2 architecture. While legacy Windows-specific modules now access via implicit remoting, the product strategy excludes future in-box inclusion in Windows due to mismatched support lifecycles.