Latest Interviews

Google's Jeff Dean on the Coming Transformations in AI

Jeff Dean, Bill Korn

This presentation outlines the trajectory of deep learning from its 2012 scaling breakthroughs toward a future of multi-modal agents and physical robotics capable of performing thousands of tasks within two years. It details a converging industry landscape where a handful of foundational models drive a secondary ecosystem of efficient, specialized architectures supported by Google's upcoming Ironwood TPU generation and Pathways system. The discussion further projects how these advancements will revolutionize scientific discovery, democratize virtual engineering through junior-level AI assistants, and reshape economic structures via dynamic compute allocation.

Open Evidence Captures Doctors’ Collective Wisdom with AI ft. Zachary Ziegler

Zachary Ziegler, Zach

OpenEvidence, a medical search tool used daily by over 25% of US physicians, recently enabled an internal medicine doctor to successfully manage an in-flight emergency for an immunocompromised cancer patient without diverting the aircraft. By synthesizing current literature and CDC data, the platform confirmed the patient did not require immediate intervention and provided a targeted treatment protocol that ensured a positive outcome upon landing. Building on this high-volume, real-time performance, the company is now expanding into direct workflow integration and developing an Aggregate Clinical Wisdom initiative to encode expert consensus from top specialists across various fields.

AI Personal Tutor for Everyone

Grant Sanderson

Building on JCR Licklider's 1960s concept of human-computer symbiosis, the initiative leverages modern multimodal reasoning models to deliver the interactive, step-by-step visualizations and voice explanations seen in benchmarks like 3Blue1Brown. This approach overcomes historical limitations by offering true personalization that decomposes complex topics into accessible formats for every learner with basic internet access. The project concludes with an open invitation for developers of AI tools to collaborate in realizing a vision where high-quality, personalized tutoring is universally available.

AI Personal Assistant

Driven by recent advances in Large Language Models, a new class of AI personal assistants is emerging to transform static task lists into automated execution systems that act as full-fledged chief of staff. These advanced tools leverage deep contextual understanding of a user's correspondence, scheduling, and work routines to independently handle emails, calendar management, and recurring processes while maintaining user approval controls. The initiative seeks strategic collaboration with startups to bring this executive assistance technology to market, ultimately offloading operational burdens so users can dedicate their attention exclusively to high-value strategic work.

Fed Hesitates on Tariffs, The New Mag 7, Death of VC, Google's Value in a Post-Search World

Philippe Laffont, Jason, Friedberg, Chamath Palihapiti, Jake Allen

During the Miami F1 Summit and Shiso Restaurant visit, hosts of the *All In* podcast engaged with high-profile guests like Sergey Brin and Tony Robbins while highlighting a $19,000 dining incident where owner Chamath waived the bill. The team outlined logistical plans for the 2025 All-In Summit in Los Angeles and analyzed complex macroeconomic factors including Federal Reserve rate decisions, tariff impacts, and antitrust regulations. Furthermore, the discussion detailed the launch of KOTU Management, a new $1.3 billion interval fund backed by Bezos and Dell families designed to invest in a "new Mag 7" across AI, robotics, and autonomous transport sectors.

“Long stocks, short bonds”

Anshul Sehgal, Chris Hussey

Federal Reserve Chair Jerome Powell prioritized stabilizing the domestic labor market while the central bank maintained current interest rates amidst stagflation risks and uncertain tariff impacts. The administration projects $300 billion in annual tariff revenue alongside increased spending, creating a fiscal environment that pressures the dollar and drives a strategic shift toward long equities and short bonds. Investors are compressing their trading horizons to hourly assessments as they navigate high volatility driven by potential job losses and the first significant inflation data release in July.

How AI Coding Agents Will Change Your Job

Tom Blomfield, David Lieb

Tom Blomfield and other Y Combinator founders describe a rapid shift where AI coding tools have surged to 50% adoption, enabling individuals to generate massive software artifacts and achieve tenfold productivity gains. This technological leap promises to replace traditional software engineering roles within a decade, transitioning the industry toward small, owner-led teams that manage AI agents rather than writing code manually. While these advances create unprecedented opportunities for solo founders to build valuable companies with minimal capital, the broader displacement of white-collar workers in fields like law and medicine is expected to trigger significant societal turbulence over the coming decades.

From CIO to CEO: TCW’s Katie Koch on running a $200B asset manager

Katie Koch, Allison Mass

TCW President and CEO Katie Koch, a former Goldman Sachs CIO with two decades of investment experience, is steering the firm's strategic evolution from its fixed-income heritage into private credit and ETFs to address a shrinking public market landscape. Leveraging significant dry powder during recent market dislocations, Koch emphasizes a culture rooted in integrity and psychological safety while executing active management strategies designed to generate outsized returns for institutional clients. Her leadership philosophy blends operational discipline with personal values regarding resilience, aiming to provide holistic investment solutions that allow borrowers and investors to navigate volatility across both public and private asset classes.

Anthropic CPO Mike Krieger: Building AI Products From the Bottom Up

Mike Krieger, Trevor Johnsen, Sam Nelsons, Emily Fortuna, Dave Elliott Smith, Mike McDonald Jr.

At a recent strategic discussion, Anthropic executive Mike McDonald Jr. outlined a paradigm shift where the distinction between AI-generated and human-created content becomes irrelevant, emphasizing instead that provenance via blockchain and compelling human storytelling will define future value. The organization is operationalizing this vision through a "bottoms-up" product philosophy and the development of the Model Context Protocol (MCP), which evolved from engineer-led integrations to establish a standardized, open framework for autonomous agent interactions and economic transactions. Internally, this approach has resulted in massive AI adoption with over 70% of code reviews generated by machines, though leaders note that non-technical organizational bottlenecks now pose the primary constraint on high-velocity development.

AI for Scientific Advancement

A new "Test Time Compute" paradigm is empowering startups to solve previously intractable challenges in drug discovery, chemical processing, mining, and power grid optimization by modernizing decades-old scientific software. This initiative aims to fundamentally accelerate physical manufacturing through AI-driven transformations that no longer rely solely on traditional PhD-level expertise. The organization is currently seeking engagement from founders and teams capable of executing these specific applications to redefine how physical things are made.

9 Years to AGI? OpenAI’s Dan Roberts Reasons About Emulating Einstein

Dan Roberts, Einstein

OpenAI demonstrated a strategic pivot toward test-time compute and reinforcement learning by showcasing models like O1 and O3 that solve complex physics problems, such as quantum electrodynamics and General Relativity, in minutes compared to human timescales. To support this new scaling paradigm where reasoning effort outweighs pre-training data, the organization plans to raise $500 billion to construct massive data center facilities in Abilene, Texas. This infrastructure investment aims to accelerate a timeline predicting that within nine years, systems will evolve from reproducing existing scientific knowledge to generating novel discoveries comparable to Einstein's major breakthroughs.

How OpenAI Built its Groundbreaking Deep Research Product ft. Isa Fulford

Isa Fulford

OpenAI's Deep Research introduces an agentic o3 model capable of executing complex, multi-step online investigations over five to thirty minutes to generate analyst-level reports. Targeted at professionals like venture capitalists and academics, the system synthesizes cross-lingual data through interactive clarifications and real-time transparency into its reasoning process. While current versions prioritize read-only browsing and citation granularity, the roadmap outlines plans to integrate these tools into broader reasoning models and enable autonomous action-taking based on findings.

A Conversation with Citadel CEO Ken Griffin | Global Conference 2025

Ken Griffin, Michael Milken

Ken Griffin critiques current U.S. fiscal policies and immigration frameworks, warning that regressive tariffs and restrictive visa rules threaten to erode national flexibility while failing to retain the international scientific talent essential for future growth. He advocates for aggressive K-12 and higher education reforms driven by school choice and data transparency to dismantle systemic inefficiencies, citing Success Academy and his own Harvard philanthropy as models for overcoming institutional inertia. Looking forward, Griffin aims to mobilize an estimated $150 billion in generational wealth to fund private-sector innovations and inspire a new era of scientific ambition similar to the 1960s space race.

Is Putin‘s narrative working?

Putin, Arkady Ostrovsky

Marked by the arrival of Chinese President Xi Jinping, Russia's 80th Victory Day parade transformed the 1945 Allied triumph into an isolated, state-orchestrated ritual that explicitly excludes Western allies. Vladimir Putin leverages this historical narrative to forge a continuous "cult of victory" that legitimizes his rule and the ongoing war in Ukraine as a reenactment of Soviet-era greatness. The event underscores Russia's geopolitical severance from the West, replacing the original concept of a shared liberation with a dependency on non-Western alliances and a focus on great power status rather than territorial expansion.

Wise Founder Taavet Hinrikus on Europe’s Tech Renaissance

Taavet Hinrikus, Clif Marriott

Tavit Tammemäe catalyzed Estonia's transformation into a European tech powerhouse by co-founding Skype, which triggered a wave of successful exits, and later launching the fintech unicorn Wise. Transitioning from operator to investor, he founded Plural in 2021 alongside four other former European CEOs to deploy €500 million in Fund II toward complex, high-impact sectors like defense and healthcare AI. The firm targets "obsessed" founders capable of building $100 billion companies, aiming to replicate the scalability of Skype and Wise within the European market.