Latest Interviews
Showing 2326–2340 of 6,420 interview transcripts.
Clear all filters- Milken Institute22 min
A Conversation with FDA Commissioner Robert Califf | Future of Health Summit 2023
Robert Califf, Conrad Kiechel, Esther Krofah
FDA Commissioner Robert Califf highlighted a critical gap in U.S. health outcomes, noting that despite high spending, life expectancy has fallen to 76.4 years while fragmented post-market evidence systems fail to answer key treatment questions. To address this, Califf proposed a unified ecosystem involving the CMS, NIH, and FDA to leverage real-world data and AI for generating rigorous post-approval evidence while incentivizing clinicians to participate in large-scale research. Additionally, the agency plans to combat persistent public distrust and medical misinformation through plain-language communication and a broad coalition of academic, industry, and community partners.
- Milken Institute16 min
A Conversation with US Senator, Amy Klobuchar, Minnesota | Future of Health Summit 2023
Senator Chris Coons leveraged his father's diagnosis of late-onset Alzheimer's to champion bipartisan legislation that has increased Alzheimer's research funding to over $3.7 billion while securing NIH grants for clinical trials. Beyond medical advocacy, Coons and Senator Josh Hawley introduced bills to ban deepfake election ads and collaborate with colleagues to integrate AI into healthcare without replacing human caregivers. This work aims to address the "sandwich generation" crisis and ensure technological innovation balances national security with the protection of voter integrity and workforce equity.
- 80,000 Hours1h 36m
Parenting insights from Rob and 8 past guests
Luisa Rodriguez, Rob Wiblin, Ezra Klein, Holden Karnofsky, Emily Oster, Russ Roberts, Spencer Greenberg, Elie Hassenfeld, Bryan Caplan, Nita Farahany
Holden Karnofsky discusses his surprising positive experience with early parenthood, noting stable sleep and increased well-being despite prevailing societal narratives of decline. The conversation integrates expert advice from figures like Emily Oster and Ezra Klein regarding the trade-offs between career demands and childcare, emphasizing that foundational stability outweighs specific parenting choices. Key themes include the methodological flaws in measuring parental regret, the biological realities of gamete quality, and practical strategies for balancing work, identity shifts, and child safety.
- Y Combinator47 min
How To Build The Future: Sam Altman
Sam Altman characterizes the current era as the optimal time for launching technology companies, projecting that Artificial Superintelligence could emerge within a decade if deep learning progress continues to compound. He outlines a five-level roadmap where AI evolves from basic chatbots to autonomous organizational managers, emphasizing that energy abundance and rapid iteration are the critical inputs for unlocking material prosperity. While acknowledging past strategic pivots and leadership turbulence at OpenAI, Altman maintains that speed and conviction allow startups to outmaneuver established corporations in achieving AGI.
America's New Consumer: CPG, Sports, Four-Wall | Jason Fiedler, Left Lane Capital
Left Lane Capital has pivoted its strategy to target high-growth physical and consumer brands in stagnant markets, leveraging a disciplined, data-driven framework inspired by SaaS metrics to evaluate opportunities in sectors ranging from beverage to sports. With assets exceeding $2 billion and a portfolio including leaders like Olipop and League One Volleyball, the firm actively sources minority stakes in Series A companies by combining aggressive outbound networking with rigorous unit economics analysis. Managing partners like Jason Fiedler prioritize businesses with strong defensibility and repeat purchase potential, aiming to capture value as legacy incumbents fail to adapt to shifting consumer preferences for healthier and more efficient solutions.
- The Diary Of A CEO2h 13m
The Investing & Crypto Expert: "We Only Have 6 Years Until Everything Changes!" - Raoul Pal
Raoul Pal warns that rapid currency debasement and stagnant real wages are eroding traditional wealth vehicles like real estate and savings, necessitating a shift toward digital scarcity assets to preserve purchasing power. He advocates for a "building season" strategy focused on deep specialization in high-value skills, with capital allocated primarily to Bitcoin, Ethereum, and Solana to capitalize on the projected transition from centralized banking to a decentralized financial system. This approach aims to secure generational freedom by aligning investment horizons with long-term macroeconomic cycles while avoiding leverage and prioritizing self-custody of assets.
- The Economist23 min
Don of a new age: Trump’s decisive win
Trump, Jason, John Prudhoe, Charlotte Howard, Idris Kalloun, Tamara Gilkes-Boer, Adam O'Neill, Aaron Braun
Donald Trump is projected to secure the presidency and a unified Republican trifecta, becoming the only president since Grover Cleveland to win non-consecutive terms while defeating Kamala Harris across key swing states. The campaign's "base-first" strategy drove significant gains among working-class and cross-racial demographics, allowing Trump to potentially appoint new Supreme Court justices and pursue an unchecked legislative agenda. Conversely, the Democratic Party faces intense internal scrutiny over its nomination process and policy failures as Republicans prepare to leverage their control of Congress and the judiciary for a second term.
- All-In Podcast2h 45m
2024 Election Night Livestream with the Besties!
Chamath, David Sacks, Friedberg, Don Jr., Ro Khanna, Dean Phillips, Phil Hellmuth, Jason Kuhn, Shane Copeland, Newt Gingrich, Steve Bannon, Aaron Levy, Nick
Projected by Polymarket and major polling outlets as a decisive victory, Donald Trump secured the presidency by capturing key swing states and shifting demographics including young males and working-class minorities. Incoming administration strategists like Elon Musk and Don Jr. plan to establish a Department of Government Efficiency to slash federal deficits and bypass bureaucratic resistance, while Steve Bannon advocates for mass deportations as an immediate economic priority. Simultaneously, Democratic figures such as Dean Phillips and Ro Khanna are calling for an introspective party overhaul focused on economic pragmatism and the rejection of establishment narratives that alienated tech leaders and independent voters.
- a16z1h 19m
Marc & Ben on AI Policy, Safety, Censorship & Unexpected Risks
Marc Andreessen, Ben Horowitz, Satya Nadella, Brad Smith, Andy Ayrey, Nick Bostrum
Amidst the upcoming US presidential election, experts are urging policymakers to pivot from speculative existential risks to concrete threats like election-disrupting deepfakes and ideological capture within AI safety teams. The discussion highlights a strategic divergence between China's centralized state control and the United States' decentralized market innovation, arguing that regulation should criminalize specific harms while preserving the open internet required for technological superiority. By rejecting the precautionary principle for non-existent scenarios, speakers advocate for a policy framework that uses digital signatures to verify content authenticity without stifling the competitive engine driving American economic and military dominance.
- 80,000 Hours1h 26m
Our very long-term future & other topics most politicians won’t touch | Andrew Yang (2021)
Andrew Yang outlines a post-scarcity vision for humanity in 500 years, warning that climate change and authoritarianism driven by scarcity pose the greatest threats to this future. To mitigate long-term existential risks and structural political failures, he advocates for institutional reforms such as ranked-choice voting, term limits, and an AI Value Added Tax to fund universal basic income. Through his organization Humanity Forward, Yang promotes a strategic "utopian" political approach that combines preventative science funding, foreign aid expansion, and democratic innovations to bridge the divide between short-term incentives and multi-generational public good.
- The Economist27 min
Vote! Our election-day special
Jason Palmer, Idris Kahloun, Aaron Braun
The 2024 U.S. presidential election will likely hinge on a razor-thin margin across seven swing states, with Pennsylvania serving as the critical tipping point for either Kamala Harris or Donald Trump to reach the 270 electoral votes required for victory. While economic concerns drive voter sentiment, the outcome faces significant uncertainty due to heightened security threats, potential legal challenges, and a potentially split Congress where control of the House remains volatile. International allies are closely monitoring the result, as the winner's approach to trade, NATO commitments, and geopolitical stability will determine the trajectory of global affairs in the coming years.
- Goldman Sachs42 min
How Clearlake Capital’s José E. Feliciano is finding value across private markets
José E. Feliciano, Michael Brandmeier
ClearLake Capital co-founders Jose Feliciano and Big Dog Ibali leverage an $80 billion asset base to execute distressed investments, restructuring, and sector-specific buyouts with a primary focus on technology and industrials. Their strategy targets a "15-year supply" of undervalued tech companies for transformation through their proprietary OPS operational framework, which integrates AI integration and business model pivots to drive recurring revenue and efficiency. Beyond financial returns, the firm actively deploys over $200 million to support underrepresented minority leaders and applies rigorous operational standards to unique assets like Chelsea FC to diversify revenue streams.
Sam Altman: What Startups Will be Steamrolled by OpenAI? Where is Opportunity?
OpenAI outlines a strategic roadmap prioritizing rapid advancements in reasoning and multimodal capabilities to drive scientific discovery, explicitly advising against building startups that rely on temporary patches for current model limitations. Leadership emphasizes a shift toward integrated AI agents capable of long-duration tasks and a compute-based pricing model, while acknowledging the competitive landscape involves both open-source collaboration and secure, scalable proprietary services. Looking five to ten years ahead, the organization forecasts an "unbelievably rapid rate of improvement" in technology and science, though significant societal changes are expected to be reserved for the distant future rather than the immediate term.
- The Economist24 min
Last-ditch pitch: America’s campaigns conclude
Rosie Bloor, Jason Palmer, Daniel Franklin, Piotr Zalewski, Anne Hanna, Zoe Bulsara
The 2024 U.S. presidential election remains a virtual tie in key swing states, characterized by intense rhetorical conflicts between Donald Trump and Kamala Harris that have intensified concerns regarding election integrity and democratic stability. Simultaneously, the Organization of Turkic States has evolved from a diplomatic forum into a strategic economic bloc of 89 nations, utilizing a shared alphabet and the Middle Corridor trade route to diversify away from Russian influence. In the UK, remote work trends have driven a 33% surge in canal boat residency as a housing solution, though this demographic shift faces mounting infrastructure risks due to insufficient government funding and rising maintenance costs.
- The Diary Of A CEO1h 55m
Scott Galloway: "There Is A 33% Chance That Trump Dies In Office!"
Scott Galloway analyzes the 2024 U.S. election as a pivotal contest driven by a crisis of masculinity and economic disparity, arguing that young men are drifting from the Democratic Party due to a perceived lack of representation regarding male-specific struggles. He contrasts Donald Trump's aggressive, populist appeal with Kamala Harris's perceived vulnerabilities, highlighting how media fragmentation and algorithmic polarization have intensified political incentives while creating a "prosperity fissure" that isolates the youth demographic. Despite betting on a competitive outcome for financial gain, Galloway warns that the nation's future stability depends on addressing the root causes of male loneliness and the potential societal consequences of unchecked technological isolation and extreme political outcomes.