Latest Interviews
Showing 16–21 of 21 interview transcripts.
Clear all filters- The Economist25 min
Why the baby business is booming
Jessica, David Smotrich, Nima, Hamish, Alan White, Nick, Emma, Catherine Wade, Mian Ridge
Valued at over $14 billion with projections reaching $130 billion, the global surrogacy industry is rapidly expanding due to rising infertility rates and restrictive laws in home countries that drive demand toward unregulated hubs. While the United States and Ukraine have historically served as major centers, tightening regulations in Asia and safety crises in Africa have forced a geographic shift that exposes gestational surrogates to severe exploitation and high maternal mortality. Experts now advocate for comprehensive international legal frameworks to replace bans with regulated standards, ensuring protections for children, intended parents, and surrogate workers across a market spanning costs from $30,000 to $200,000.
- All-In Podcast1h 38m
E130: DeSantis's Twitter Spaces, debt ceiling, Nvidia rips, state of VC, startup failure & more
DeSantis, Calacanis, Friedberg, Chamath Palihapitiya, David Sacks, Nick
Governor Ron DeSantis launched his presidential bid in a historic Twitter Spaces event hosted by Elon Musk and David Sacks that briefly drew over one million listeners before crashing under the weight of its massive audience. While the technical meltdown prompted traditional media outlets to frame the incident as a fiasco, the episode succeeded in showcasing DeSantis's composure and allowing voters to engage with unfiltered candidate discourse. The broadcast also featured extensive analysis of the U.S. debt ceiling crisis, Nvidia's record-breaking AI earnings, and the diverging fortunes of Silicon Valley startups during the current investment climate.
- All-In Podcast1h 29m
E108: Doxing debate, Nuclear fusion breakthrough, state of the markets & more
Jason, Sacks, Chamath, Calacanis, Friedberg, Cernovich, Sachs, Freeburg, Jay Cal, Jake, Draymond, Dave Chappelle, Chris Rock, Steph Curry, Joe Lacombe, Phil Helmuth, Bill Gates, Mark Andreessen, Sam Altman, Chris Dixon, Nick
Elon Musk announced a new policy banning persistent real-time location tracking of individuals to prevent stalking, while experts debated the balance between personal safety and free speech amidst his broader moderation challenges. Simultaneously, scientists at the National Ignition Facility achieved a historic net energy gain in nuclear fusion, sparking discussions on commercialization timelines and the economic viability of fusion versus solar power. In the financial sector, a stark correction in private equity and venture capital valuations is reshaping startup strategies, with firms pivoting toward capital efficiency and private equity acquisitions as public market multiples collapse.
- All-In Podcast1h 25m
E99: Cheating scandals, Twitter updates, rapid AI advancements, Biden's pardon, Section 230 & more
Biden, Chamath, Calacanis, Friedberg, Nick, Sax, David Sacks, J Cal, Phil Helmuth, Jason
Hosts conclude their 99-episode run while addressing production overloads, a surge in cross-industry cheating scandals, and Elon Musk's strained acquisition of Twitter amidst complex financial hurdles. The panel further analyzes Tesla's AI robotics advancements, President Biden's cannabis pardons, and the Supreme Court's upcoming review of Section 230 liability as experts debate free speech frameworks. Key announcements include the upcoming "All In Meetups" in Zurich and Miami, a high-stakes poker tournament featuring Chamath Palihapitiya, and the revelation that Jason Calacanis coined the title "Data Scientist" in 2008.
- All-In Podcast1h 25m
E97: SPAC updates, public/private market overview, Putin's end game & more
Putin, Chamath, Calacanis, Friedberg, Jake, Nick, David, Jason, Sacks
Chamath Palihapitiya announced the liquidation of his IPOD and IPOF SPACs to return capital to investors, citing an unsustainable market environment where valuation gaps and volatility have frozen exits for late-stage private companies. He forecast a catastrophic "washout" for the broader SPAC sector while criticizing systemic failures in venture capital diligence and ESG frameworks that obscure financial reality. The discussion further addressed looming geopolitical risks, including escalation in Ukraine and protests in Iran, arguing that institutional decay and demographic shifts are driving instability that requires a nuanced diplomatic approach rather than intervention.
- Milken Institute58 min
The Role of Universities in Accelerating Bioscience Research
David Baltimore, Joel Burdick, James Economou, Michael Quick, Owen Witte, Stephen Mayo, Steve Mayo, Nick, Francis Collins, Remy, Joe Boistak, Charles, Eric Green, Ray Deshaies
A consortium of leading academic figures, including Nobel Laureate David Baltimore and experts from Caltech, UCLA, and USC, convened to evaluate the intersection of biological engineering and clinical translation in the face of funding constraints. The panel detailed successful strategies for "engineered immunity" projects, such as converting muscle cells into antibody producers and conducting early-stage human trials within university settings, while highlighting the critical need for interdisciplinary programs that bridge the gap between engineering PhDs and MDs. Despite progress, participants identified a persistent "valley of death" in early-stage financing and urged a cultural shift toward professional management and team-based funding mechanisms to sustain innovation.