Latest Interviews

Deep Dive on Threads with the Head of Instagram Adam Mosseri

Adam Mosseri, Harry Stebbings

Threads achieved immediate high-volume adoption by importing Instagram's social graph to prevent a zero-follower start, though Adam Mosseri stresses that long-term retention remains the primary strategic focus over initial sign-up numbers. The platform successfully activated creators in key verticals without direct payments, yet it faces technical hurdles such as a delayed European rollout due to data separation laws and the absence of core editing features. Mosseri argues that sustainable monetization must prioritize predictable revenue tools like subscriptions over volatile direct payments, while acknowledging that critical mass requirements for user retention vary significantly across different cultural markets.

E141: State of Series A's, VC dry powder, IPO window opens + more with Bill Gurley & Brad Gerstner

Bill Gurley, Brad Gerstner, Calacanis, Friedberg, Chamath Palihapitiya, David Sacks, J. Cal

In this All-Star Summer episode, hosts J.C. Calacanis and David Sacks discuss venture capital dynamics and career strategy with guests Brad Gerstner and Bill Gurley. The panel analyzes the post-2021 market correction, noting that Series A valuations have returned to 2019 levels while predicting a near-term distress cycle for overvalued late-stage companies. Additionally, the conversation explores investment discipline regarding AI mania, critiques of private market valuation opacity, and the accelerating global risks of climate change alongside historical performance benchmarks.

The future of money: three ways to go cashless

Following a pandemic-driven acceleration in digital adoption, the global payments landscape now revolves around three distinct models: the high-fee credit card ecosystems of the West, China's dominant closed fintech networks, and India's government-backed Unified Payments Interface. While Western banks and processors like Visa and Mastercard leverage interchange fees to fund consumer rewards and protections, China's Ant Financial and Alibaba faced regulatory blockades after their market dominance threatened financial stability. Conversely, India's interoperable UPI system processes one-third of the nation's GDP by enabling direct bank-to-bank transfers and data ownership, effectively creating a nonprofit alternative that prevents single-entity control over financial infrastructure.

CMO Of Netflix: "Work Life Balance" Is BAD Advice! I Lost My Baby & My Husband!

Steven, Bozoma Saint John

Bozema St. John, a marketing executive who previously worked with Apple, Netflix, and Pepsi, leverages a life defined by political displacement, the loss of a daughter, and the death of her husband to advocate for a leadership philosophy rooted in intuition and radical self-prioritization. Her narrative highlights a career breakthrough where she secured a position from Spike Lee by critiquing his script as a junior employee, a moment that established her belief in fostering teams where junior members feel safe challenging strategy. St. John advises aspiring leaders to reject linear paths in favor of listening to their own voices and practicing "selfishness" to ensure long-term fulfillment, arguing that personal clarity is the only way to avoid ending up unsatisfied in one's final days.

Jason Lemkin: Every VC has a FRAUD in their portfolio; The IPO market is about to EXPLODE | E1046

Jason Lemkin, Harry Stebbings

In a comprehensive market analysis, venture capitalist Jason Lemkin forecasts a resurgence of SaaS IPOs in late 2024 while warning against the return of the 2021 frenzy and highlighting a critical split in seed-stage funding driven by insider liquidity. Lemkin advises new fund managers to prioritize rapid "winner" creation over conservative capital preservation and urges investors to target unproven founders priced out of mega-fund reach rather than chasing overvalued institutional leads. Despite his skepticism regarding diluted work ethics and the mathematical unsustainability of megafunds, he predicts that efficient, mid-growth SaaS companies will attract significant capital through secondary transactions and a renewed public market appetite.

50 Founders Share How They Got Their First Customers

Founders validated their personal finance and ag-tech concepts through aggressive outbound strategies and viral inbound channels, generating nearly 1,000 waitlist sign-ups and converting early users into paying customers within days. By leveraging diverse acquisition tactics ranging from door-to-door pitches to Reddit launches, teams achieved significant metrics such as a 50-to-10,000 follower surge and immediate revenue from non-coded solutions. These early adopters now serve as the foundation for a demo day strategy, with founders actively pivoting job offers into sales opportunities and preparing targeted outreach to major industry executives.

How I Became the Head of Instagram -- Adam Mosseri

Adam Mosseri, Harry Stebbings

The speaker details their evolution from an autonomous early-career designer at Facebook to the CEO of Instagram, emphasizing a shift from silent execution to a leadership style defined by delegated authority and high-frequency communication. Facing the emotional isolation of founder departures, they rebuilt the executive team by prioritizing long-term stability and group chemistry while advising incoming leaders to leverage diverse sector experiences to clarify their values. Ultimately, the narrative highlights that sustaining morale and driving success requires a sponge-like absorption of institutional knowledge followed by decisive product delivery rather than reactive internal reassurance.

Dario Amodei (Anthropic CEO) — The hidden pattern behind every AI breakthrough

Dario Amodei

Anthropic CEO Dario Amodei projects that models indistinguishable from generally educated humans will emerge within two to three years, constrained primarily by safety regulations rather than compute or data scarcity. This trajectory carries significant risks, including the potential for state-level actors to utilize frontier models for biological attacks, prompting strict security protocols and the creation of a Long-Term Benefit Trust to legally prioritize safety over shareholder interests. To navigate these challenges, Anthropic employs mechanistic interpretability as a verification tool and advocates for international governance structures while preparing for an economic landscape dominated by a few large-scale infrastructure "leviathans."

Vinod Khosla: How AI Impacts Healthcare, Energy, Geo-Politics, Media and Climate Change | E1045

Vinod Khosla, Harry Stebbings

Venture capitalist Vinod Khosla identifies the recent release of ChatGPT as the "browser moment" for artificial intelligence, signaling a transition from experimental phases to widespread consumer utility despite inevitable historical hype cycles. He projects that while AI will potentially double global GDP growth and revolutionize sectors like healthcare through protein folding solutions, it will also trigger rapid job displacement and exacerbate inequality, necessitating new social contracts like Universal Basic Income to manage the disruption. To mitigate these risks and secure a sustainable future, Khosla advocates for aggressive investment in fusion energy and domestic tech growth, particularly in India, to replace fossil fuels and address demographic crises in aging economies.

Instagram CEO Reveals His Biggest Mistake

Adam Mosseri, Harry Stebbings

Adam Mosseri defends Instagram's strategic pivot toward video and algorithmic recommendations as a necessary response to shifting teen usage patterns, despite sparking the "Panavision" controversy through unpopular design changes. To address feature bloat, the company unshipped underused tools like the Activity Feed and reallocated the Stories team to messaging, prioritizing "Notes" to engage younger demographics while admitting the interface has become overly complex. Leadership now commits resources to proactively removing unused features and consolidating design elements to prevent long-term user friction, even as Mosseri continues to engage directly with critics on Reddit.

WARNING: ChatGPT Could Be The Start Of The End! Sam Harris

Sam Harris, Steven

Sam Harris argues that superhuman artificial intelligence presents an inevitable existential threat due to the fundamental inability of humans to align with or comprehend vastly smarter systems. He warns that immediate risks include the collapse of truth through AI-generated misinformation and the displacement of high-status cognitive jobs, necessitating a shift toward Universal Basic Income and a redefinition of human purpose. Consequently, Harris advocates for indefinitely pausing AI development until the alignment problem is solved, prioritizing existential safety over the potential benefits of accelerated technological progress.

Georges St-Pierre vs Lex Fridman in Jiu Jitsu and MMA

Georges St-Pierre, Lex Fridman, GSP

Georges St-Pierre outlines a technical framework for MMA grappling that emphasizes footwork-driven distance control, specific setups like the jab-cobra explosion for double legs, and structural integrity when navigating guard or seeking dominant positions. He evaluates potential opponents by prioritizing technical skill over innate toughness, noting that while Elon Musk possesses exceptional physical attributes, his lack of specific training experience creates a significant hurdle against seasoned fighters. Ultimately, GSP advocates that both he and Musk should leverage their influence to generate broader global benefits rather than engaging in a contested exhibition match.

Ilir Sela: How I Founded Slice Pizza & Became One of Macedonia’s Largest Employers | E1044

Ilir Sela, Jeff Richards, Ben Sun, Harry Stebbings

Slice founder Ilya Lazarevski bootstrapped the pizza technology platform from zero in 2015, rejecting an $18 million acquisition to reinvest profits and leverage capital specifically to onboard elite leadership rather than simply funding growth. By adopting a vertical strategy that integrated independent pizzerias into a digital ecosystem, Slice has helped expand the US pizza industry from 60,000 to 80,000 shops while maintaining operational simplicity through a globally distributed team. Looking toward a public listing by 2028, Lazarevski remains actively involved in decision-making to navigate scaling complexities and continues to emphasize that hard work and deep customer intimacy, rather than luck, drive the company's trajectory.

Comfort Food, Climate, and the Future of Our Plates

Julia Collins, Nyesha Arrington, Alvin Salehi

The event unites diverse voices from the Chef platform and Planet Forward to explore how technology and regenerative practices are democratizing food entrepreneurship and combating climate change. Speakers detail how data-driven tools lower barriers for underrepresented chefs while AI and regenerative agriculture strategies transform food systems into carbon sinks. Together, these insights advocate for a future where sustainable eating, emotional connection to culinary heritage, and accessible business models empower individuals to reshape the industry from home kitchens to brick-and-mortar success.

The Man Thats Ageing Backwards: “I Was 45, I’m Now 18!” - Bryan Johnson

Bryan Johnson, Steven

Entrepreneur and longevity researcher Brian Johnson has abandoned his $800 million tech exit to pursue a singular mission of indefinite human survival by treating the body as an algorithm-led system. Johnson enforces a rigorous "Blueprint" protocol involving 111 daily supplements, strict caloric limits, and sleep optimization to reverse his biological age, while arguing that aligning humanity's fragmented goals with the "don't die" imperative is essential to prevent collapse from AI misalignment or environmental degradation. This radical shift from traditional decision-making aims to transform the 35 trillion cells of the human body into a unified cooperative unit, creating a foundational template for global survival before artificial intelligence surpasses human governance.