Latest Interviews

Block CTO Dhanji Prasanna: Building the AI-First Enterprise with Goose, their Open Source Agent

Dhanji Prasanna, Sonya Huang, Roelof Botha

Block CTO Dhanji Prasanna drives a strategic shift from a siloed management model to a centralized AI-first architecture, spearheading the "Goose" project that functions as an open-source agent to orchestrate workflows across internal systems. This initiative, which evolved from an internal hack week, enables high autonomy for engineers by integrating diverse LLMs and saving 25% of manual hours through shared, self-learning scripts. Looking forward, Block aims to transition from single-agent co-pilots to collaborative swarm intelligence by 2030, while simultaneously extending this technology to its public-facing Square AI for merchant financial simulations.

Anduril CEO: China Has Scale. Can America Catch Up?

Ben, Marc, Erik Torenberg, Brian Schimpf, Chris Power

A strategic assessment reveals a critical gap in U.S. defense industrial capacity, where Russia currently outproduces NATO on 155mm munitions and existing stockpiles would deplete within six to seven days of conflict. This deficit stems from decades of offshoring, an aging skilled workforce, and a reliance on technical superiority rather than mass production, leaving the U.S. unable to sustain high-intensity wars or effectively deter China in scenarios such as an invasion of Taiwan. To address these vulnerabilities, experts recommend a "factory-first" approach featuring government-backed long-term offtake agreements, concentrated capital investment in scaled manufacturing entities, and regulatory reforms to rebuild domestic supply chains and reinvigorate the talent pipeline.

Wes Cummins, Founder & CEO of Applied Digital: Ellendale’s Purpose Built AI Factory in North Dakota

Wes Cummins

Applied Digital is expanding its high-power density data center operations by securing a 400-megawatt contract with CoreWeave to construct a North Dakota campus utilizing stranded wind energy and designed for AI workloads. The company transitioned from Bitcoin mining to Tier 3 semiconductor-grade infrastructure after spending $5 billion on this project to ensure "five nines" reliability and extreme cooling standards for hyperscalers. With approximately 3% ownership by NVIDIA, the firm is capitalizing on the shortage of available power sites in the U.S. heartland while planning future phases that will integrate gas assets and explore nuclear options like small modular reactors.

RAISE 2025: Building AI for Security-Minded Enterprises

A French math PhD turned AI leader leveraged their academic background to build the Llama family at Meta before joining Cohere to prioritize business traction and secure, localized enterprise solutions. The speaker details a strategy where data quality and strategic partnerships, such as those with Fujitsu and RBC, drive the development of models optimized for specific languages and industries rather than pursuing Artificial General Intelligence. By focusing on grounded generation and flexible hosting options, the organization ensures data sovereignty and verifiable outputs for regulated sectors while avoiding the inherent risks of trying to mimic human cognition.

RAISE 2025 : Fireside Chat with Amit Bendov, CEO & Co Founder of Gong

Amit Bendov, Brian Bauman, Amit Bhandav

Founded by Amit Bhandav to solve CRM data gaps, Gong.io leverages autonomous AI to capture sales communication and transform enterprise productivity from manual entry to instant, context-aware insights. Operating on a maturity scale between assisted and near-autonomous levels, the platform currently handles high-volume administrative tasks while preserving human judgment for high-liability decisions. As enterprise leaders demand integrated AI for revenue generation, Gong drives adoption by eliminating briefing bottlenecks for Fortune 500 clients while fostering a unique culture that prioritizes employee personal branding and deep client relationships.

Inside the GLP-1 Gold Rush: Eli Lilly CEO on New Breakthroughs, Addiction & Mental Health, Pricing

Dave Ricks, Chamath, Jason, Friedberg

Eli Lilly CEO David Ricks has steered the company to an 860% market capitalization increase and record-breaking Mounjaro sales by leveraging a massive research workforce and aggressive manufacturing expansion to secure global dominance in GLP-1 therapies. While the firm faces capital shortages in the broader biotech sector, it is diversifying its pipeline beyond weight loss to address brain disorders and developing oral formulations to improve accessibility without compromising the high R&D reinvestment model Ricks defends. Personalized by Ricks' own successful treatment, the company balances aggressive clinical innovation with strategic supply chain controls to maintain its competitive edge against emerging international rivals.

Will macro fuel more stock gains?

Dominic Wilson, Josh Schifrin

Analysts project the Federal Reserve will implement two additional rate cuts by year-end to address labor market risks, targeting a terminal rate near 3% as the economy navigates mixed employment signals and structural uncertainties. This easing cycle, expected to conclude by December 2026, aims to support risk assets and sustain growth while keeping inflation pressures contained amid a bearish outlook for oil and tariff impacts. Despite valuation concerns and skepticism regarding AI capital expenditure sustainability, the prevailing view suggests that resilient fundamentals and policy shifts will maintain upside momentum for the broader market through 2026.

How much protein do you really need?

Alok Jha, Tim Cross

A recent discussion detailed the physiological role of proteins as primary structural materials while analyzing dietary guidelines that range from the World Health Organization's 0.8 grams per kilogram recommendation to sports science suggestions of up to 1.6 grams per kilogram. The presentation highlighted that excessive protein intake above this threshold offers no additional muscle growth benefits and may pose kidney risks, particularly when derived from saturated fats and processed meats. Instead of prioritizing extreme dietary calculations, experts advised combining consistent strength training with enjoyable exercise routines to ensure long-term health and muscle maintenance.

From Vibe Coding to Vibe Researching: OpenAI’s Mark Chen and Jakub Pachocki

Mark Chen, Jakub Pachocki, Anjney Midha, Sarah Wang

OpenAI researchers Mark and Jakob Sutskever outline a strategic roadmap centered on GPT-5, which aims to mainstream advanced reasoning and automate scientific discovery by merging the capabilities of instant-response and deep-thought models. This approach shifts evaluation metrics from solving static competition problems to generating economically relevant insights and extending autonomous time horizons to several hours through reinforcement learning. The organization distinguishes itself by balancing protected fundamental research teams with product accountability, prioritizing talent that persists through failure to overcome current limitations in coding autonomy and physical robotics.

Eric Schmidt on AI, the Battle with China, and the Future of America

Eric Schmidt, Chamath, Jason, Friedberg

Former Google CEO Eric Schmidt outlines a strategic framework where the immediate AI revolution remains underhyped and distinct from the imminent arrival of autonomous agents, while warning that Western nations must counter China's aggressive pivot toward open-weight models and advanced robotics. Schmidt anticipates a future military doctrine defined by millions of AI-driven drones that create high-deterrence stalemates rather than traditional combat, driven by the obsolescence of fixed military infrastructure. Simultaneously, he emphasizes that US geopolitical resilience depends on leveraging domestic capital markets and releasing smaller open-source models to maintain control over handheld device proliferation amidst global demographic declines.

Taking Bold Bets: NIH and the Future of Biomedical Science

Dr. Jay Bhattacharya, Erik Torenberg, Vineeta Agarwala, Jorge Conde

Secretary Xavier Becerra announced a $50 million federal investment to launch the Autism Data Science Initiative, selecting 13 teams from 250 applicants to address the rising prevalence of autism and the lack of effective therapies. Concurrently, the NIH is implementing comprehensive reforms to resolve the scientific replication crisis, centralize peer review, and prioritize early-career investigators to foster high-risk innovation. These strategic shifts aim to rebuild public trust through transparent communication, integrate AI for capacity augmentation, and tackle chronic diseases while ensuring rigorous, reproducible medical standards.

Why Now Is The Best Time To Build In Crypto

Harj Taggar, Jesse Pollak

Led by Base founder Jesse Pollock, industry leaders declare a new golden age for crypto building driven by mature infrastructure that has reduced transaction costs to near zero and achieved regulatory clarity through legislation like the Genius Act. This environment enables a shift from legacy financial systems to programmable, censorship-resistant networks where stablecoins facilitate global access and tokenization allows creators to retain ownership of their capital. As a result, Coinbase and Y Combinator are prioritizing technical founders who apply these scalable Layer 2 architectures to solve real-world problems, signaling a surge in high-quality engineering teams ready to integrate AI and financial services over the next 18 months.

Dylan Patel on the AI Chip Race - NVIDIA, Intel & the US Government vs. China

Dylan Patel, Erik Torenberg, Sarah Wang, Guido Appenzeller

NVIDIA and Intel have established a transformative $5 billion strategic partnership to jointly develop custom data center and PC products, a move that significantly boosted NVIDIA's stock and acknowledged the industry's shift from CPU to GPU dominance. This alliance contrasts sharply with China's aggressive pursuit of semiconductor self-sufficiency, where Huawei navigates US export bans and high-bandwidth memory bottlenecks through domestic innovation and alleged smuggling channels. Simultaneously, hyperscalers like Oracle and AWS are capitalizing on surging demand with massive infrastructure deals and repurposed capacity, while the market faces technical complexities in deploying next-generation Blackwell architectures and optimizing hardware for specific inference workloads.

Charlie Kirk Murder, Assassination Culture in America, Jimmy Kimmel Suspended, Ellison Media Empire

Charlie Kirk, Jimmy Kimmel, Ellison, Chamath, Jason, Friedberg, Zach, Sax

Following the murder of conservative activist Charlie Kirk by Tyler Robinson, a discussion emerges attributing the violence to a radicalized generation shaped by algorithmic extremism and social isolation rather than a random act. The event has triggered a broader national debate regarding the rising acceptance of political violence and the specific cancellation of Jimmy Kimmel, which hosts frame as a symptom of media consolidation and the erosion of free speech norms. Participants conclude by calling for a societal pledge against political violence while analyzing how tech giants and media moguls are reshaping the information landscape that fuels such ideological fractures.

Will Fed Cuts Drive Stocks Higher?

Tony Pasquariello, Chris Hussey

The Federal Reserve signaled a trajectory of five rate cuts over the next few years while revising upward its growth and inflation expectations, a move Goldman Sachs views as consistent with its internal forecasts despite minor timing differences. Investment strategists advocate for a continued focus on US big-cap technology and Japan due to strong earnings momentum and shareholder reforms, while remaining cautious about European markets and potential valuation compression in the US. Market participants will closely monitor upcoming employment data and the evolving US labor landscape as volatility is expected to rise following the October earnings reporting season.