Latest Interviews
Showing 1426–1440 of 4,873 transcripts.
Clear all filters- Goldman Sachs13 min
Stagflation and the Fed's next move
The U.S. economy confronts a stagflationary shock driven by spending cuts, restrictive immigration policies, and tariff uncertainty, creating a complex backdrop for Federal Reserve monetary strategy. Policymakers are advised to pause rate decisions at the May meeting to assess new trade data while maintaining a tough rhetorical stance to anchor inflation expectations without pre-committing to specific future cuts. As the Fed balances its dual mandate amidst potential political pressure, global investors are cautiously retaining dollar allocations despite signs of institutional skepticism and capital outflows that are currently characterized as temporary positioning rather than a permanent strategic shift.
- The Economist7 min
Why US tariffs on China will hurt American shoppers
Effective May 2, the Trump administration revoked the "de minimis" exemption, eliminating duty-free status for Chinese imports under $800 and directly impacting the US market-dependent business models of fast-fashion giants Shein and Temu. Facing high tariff costs that threaten their core pricing advantages, these companies currently rely on direct shipping from Chinese hubs while navigating geopolitical pressure from Beijing against relocating manufacturing to avoid tariffs. Experts anticipate Shein and Temu will survive this regulatory shift by diversifying into new global markets and transitioning into multinational corporations despite strict US efforts to close trade loopholes.
- a16z37 min
What Is an AI Agent?
Guido Appenzeller, Matt Bornstein, Yoko Li
Industry experts define AI agents as multi-step systems capable of dynamic reasoning and tool usage, distinguishing them from simple prompt wrappers despite widespread marketing inflation. Current market adoption is constrained by data silos, security gaps in authentication, and the technical difficulty of enabling non-deterministic models to interact reliably with fragmented user environments. Ultimately, the field is shifting toward specialized workflows and multimodal capabilities, with agents expected to become invisible infrastructure within two to five years rather than standalone products.
- Goldman Sachs10 min
Time to buy bonds?
Despite a macroeconomic shift toward higher inflation and lower growth driven by tariff announcements since April, the 10-year Treasury yield has remained stable while credit spreads have partially recovered from their initial widening. Goldman Sachs Asset Management has strategically increased portfolio duration and favored Investment Grade credit over High Yield, citing bond outperformance versus equities and the U.S. dollar's status as a global safe haven. Although the firm acknowledges an increased recession probability and sector divergence within travel, it concludes that current market pricing does not yet fully reflect downside risks, prompting continued allocation to structured credit opportunities.
- a16z21 min
How to Enable a Manufacturing Renaissance
Bryon Hargis, Chris Power, Ian Cinnamon
Amid a strategic space race against China, Los Angeles-based startups Apex and Hadrian are scaling satellite manufacturing and automated defense production to counter rapid geopolitical shifts and a domestic labor crisis. Despite facing significant regulatory hurdles regarding energy infrastructure and permitting, these companies are successfully attracting top software talent to traditional aerospace roles by merging Silicon Valley innovation with industrial capacity. Their unified efforts aim to establish a resilient, onshored U.S. industrial base while pressuring policymakers to streamline export licensing and incentivize skilled trade careers.
What Does it Take to Be Good at Series A and B Today?
Rory O'Driscoll, Jason Lemkin, Fabrice Grinda, Harry Stebbings
Venture capital markets are currently navigating a dual reality defined by an AI-fueled "gold rush" and a constrained liquidity environment where exit windows remain closed. Investors are diverging between aggressive "megatrend" bets on artificial intelligence and defense technology versus deep-value plays in digitized B2B sectors, while grappling with rapidly evolving risks such as model obsolescence and geopolitical instability. This high-velocity landscape is forcing strategic shifts toward earlier exits, a preference for "deranged" founders capable of exponential scaling, and a structural reevaluation of how private company lifecycles align with technological obsolescence.
- Goldman Sachs37 min
Nasdaq CEO Adena Friedman on the future of public markets
Adena Friedman, John Waldron, Allison
Led by CEO Adena Friedman, the NASDAQ has evolved from a US electronic stock exchange into a global technology platform supplying critical infrastructure to 130 markets while prioritizing liquidity, transparency, and anti-financial crime solutions. The organization recently navigated record trading volumes and leverages hybrid cloud architecture and generative AI to enhance market resilience, with a specific strategic focus on the anti-financial crime sector following the Verifin acquisition. Looking forward, leadership advocates for structural regulatory reforms to reverse the decline in public listings and attract capital back to public markets against the backdrop of rapid private market growth.
- a16z27 min
Biotech CEO on where we are in the fight to cure cancer
Former Halozyme CEO Jonathan Lim leverages his experience scaling biotech startups to lead Araska Therapeutics, a company targeting the historically undruggable RAS pathway with a pipeline including the pan-RAF inhibitor Naporafenib. Concurrently, his family office, City Hill Ventures, manages a diversified portfolio of life sciences assets and media projects that parallel the high-risk, high-reward dynamics of pharmaceutical development. Lim's strategy emphasizes capital preservation and the combination of novel molecular glues with standard therapies to drive long-term remission rates beyond current limits in pancreatic, lung, and colon cancers.
- Dwarkesh Patel1h 16m
Mark Zuckerberg — AI will write most Meta code in 18 months
Meta has officially launched four Llama 4 models, immediately releasing the efficient Scout and Maverick variants while developing a massive two-trillion parameter "Behemoth" to distill intelligence into smaller, consumer-ready agents. The company is shifting its evaluation metrics from external leaderboards to internal product performance, prioritizing low-latency, full-duplex voice interactions and AI-driven content that reacts dynamically to user input across its billion-person ecosystem. By leveraging internal coding agents to accelerate development and advocating for a dual ad-supported and premium business model, Meta aims to narrow the gap with closed-source competitors while navigating infrastructure bottlenecks that will constrain the pace of an anticipated intelligence explosion.
- a16z1h 31m
How Andreessen Horowitz Disrupted VC & What’s Coming Next
Marc Andreessen, Ben Horowitz, Erik Torenberg
Established in 2009 by Ben Horowitz and Marc Andreessen, Andreessen Horowitz (a16z) redefined venture capital by replacing the passive "Sushi Boat" model with an active, capital-intensive platform strategy designed to provide deep operational support for "Full Stack" companies across verticals like AI and crypto. This structural shift responded to an overfunded market and dysfunctional public exits, enabling the firm to scale from a traditional two-person partnership into a decentralized network of expert operators that rivals major tech giants in domain capability. By prioritizing founder success over secrecy and leveraging a media-centric branding approach, a16z has transformed the VC asset class into a mechanism that fuels a wider pool of ambitious entrepreneurs despite the enduring unpredictability of human judgment in project selection.
- Sequoia Capital56 min
The Quest to ‘Solve All Diseases’ with AI: Isomorphic Labs’ Max Jaderberg
Founded to construct a general AI-driven drug design engine, Isomorphic Labs has leveraged Demis Hassabis's Nobel Prize-winning leadership and Max Yoderberg's AI expertise to release AlphaFold 3, a diffusion-based model that predicts the 3D structures of proteins, DNA, RNA, and small molecules. By replacing months of traditional crystallization with instant in-silico analysis, the company collaborates with industry partners like Eli Lilly and Novartis to navigate the 10^60-sized chemical space and advance programs in oncology and immunology without operating its own wet labs. This approach positions AI as a fundamental, indispensable tool for the entire pharmaceutical industry within five years, while the firm advocates for new regulatory frameworks to validate these predictive models for clinical trials.
- a16z44 min
The Software Crisis Behind America's Infrastructure
Leila Hay, Phillip Buckendorf, Leonard J. Kosinski
ASI Co-founders Philip and retired General Leo Leo address the United States' critical software crisis by merging commercial aviation technology with Department of Defense logistics to replace fragmented legacy systems. Their strategy establishes a unified "collective logistics" framework that leverages AI-driven predictive capabilities to secure supply chains against cyber threats and geopolitical instability. By standardizing software stacks across the private and public sectors, the organization aims to rapidly modernize military infrastructure and maintain U.S. power projection capabilities by 2034.
Plural Partner, Taavet Hinrikus: Why Founders Will Realise Multi-Stage Funds Damage Seed Rounds
Taavet Hinrikus, Harry Stebbings
Venture capitalist Tal Talbot outlines Plural's strategic shift toward a low-fee, high-volume model that aligns incentives by charging half the industry standard management fee and requiring partners to personally back every investment. The firm targets deep hard-tech sectors like defense, fusion, and AI, explicitly rejecting saturated enterprise software markets to pursue 100x returns while advocating for European geopolitical sovereignty through government purchasing and unified capital mobilization. With Fund II expanding its reserve ratio to 50% and targeting companies such as Helsing and Proxima Fusion, Plural aims to rebuild Europe's critical industries amid a tri-polar global landscape where traditional VC metrics are declining.
- The Diary Of A CEO2h 14m
The Savings Expert: The Truth About America Collapsing! The Cost Of Living Is About To Skyrocket!
This discussion analyzes the volatile mechanics of current tariffs, the historical realities of global manufacturing specialization, and the role of artificial intelligence in accelerating economic disruption. It further outlines a philosophy of wealth creation centered on endurance, humility, and the strategic management of risk to achieve financial independence rather than status. The narrative concludes with actionable guidance for the next generation, emphasizing the development of interpersonal skills and the value of experiencing scarcity to foster resilience and long-term contentment.
- All-In Podcast1h 30m
Trump Rally or Bessent Put? Elon Back at Tesla, Google's Gemini Problem, China's Thorium Discovery
Trump, Bessent, Elon, Andrew Ross Sorkin, Chamath, Jason, Friedberg
A panel of experts analyzes global market dynamics, noting that recent rallies stem from trade deal expectations rather than Federal Reserve support, while highlighting strategic tensions over China's control of rare earths and its lead in thorium energy research. The discussion extends to foreign policy, where participants advocate for accepting the Istanbul Deal to end the Ukraine war and criticizing the moralistic approach to nation-building. Finally, the group evaluates corporate strategies for Alphabet and Tesla, the fiscal hurdles facing the Department of Government Efficiency, and the regulatory complexities surrounding Nvidia's global supply chain.