Latest Interviews

New LLMs Are Unlocking Robot-Use Agents

Francois, Hanmei, Vincent, Jay

Frontier researchers and startups like Waddle Labs are advancing a paradigm shift toward general-purpose "robot use agents" that leverage coding-based policies and cross-modal data to perform complex physical tasks without specialized fine-tuning. By applying the "Bitter Lesson" principle to consolidate diverse datasets, these systems utilize in-context learning and memory consolidation architectures to rapidly adapt to new environments, with current demonstrations successfully executing multi-step manipulation challenges. Industry projections indicate that as latency decreases and internal world representations converge, economically viable, general-purpose robots capable of performing competent human-like tasks will emerge within two years.

Startups Are Moving From Bits to Atoms

Garry, Jared, Diana, Harj

Recent YC batches have witnessed a hard tech resurgence, with the physical sector share tripling to 20% alongside a historic 1-in-6 PhD founder rate driven by AI acceleration and macroeconomic shifts in defense and space. Concurrently, the software landscape has pivoted toward revenue-generating agentic workflows and solo founders, as AI tools enable single individuals to execute complex full-stack operations and experienced founders to manage autonomous coding teams. These trends collectively signal a fundamental shift where advanced physical intelligence, specialized silicon, and autonomous agents are redefining startup viability and scaling strategies.

Open Models Are Collapsing The Cost Of AI

Jeffrey Morgan

Driven by cost efficiency and customization needs, enterprises are increasingly adopting open AI models, with major corporations like AT&T shifting significant token consumption away from proprietary systems toward flexible, locally deployable solutions. Ollama has emerged as a critical orchestration layer for this ecosystem, supporting 85% of Fortune 500 companies and facilitating a hybrid deployment strategy that balances local hardware capabilities with cloud-based inference for complex tasks. This market shift positions open models to handle the majority of daily enterprise workflows, reducing reliance on expensive frontier closed models while navigating geopolitical security concerns through rigorous supply chain verification and secure hosting environments.

Paul Graham On Startups, Ambition, and Great Founders

Paul Graham, Vivian Shen

Paul Graham delivered his 47th Y Combinator batch talk, highlighting a shift toward high-seriousness ventures in logistics and cancer research while defining founder ambition through the "formidable" archetype of those who consistently achieve their goals. Graham analyzed the current AI landscape, noting its uneven "jagged frontier" and the economic reality that token costs now eclipse salaries despite rapid price declines. He concluded that Y Combinator's ecosystem remains vital for peer collaboration and that the next trillion-dollar company will emerge not from a specific idea but from formidable founders capable of adapting to shifting market conditions.

The World’s Largest Electric Aircraft Just Flew

Gustaf Alströmer, Anders Forslund, Clara

Heart Aerospace successfully flight-tested the world's largest electric airplane, a 100-foot wingspan aircraft capable of carrying 36 passengers on short-haul routes with minimal operating costs. Led by CEO Anders Forslund and co-founder Clara, the Los Angeles-based team utilized a hybrid configuration to achieve a 500-mile range while significantly reducing maintenance and noise through the replacement of traditional jet engines with electric motors. This clean-sheet design, which marks the first new American airliner in 18 years, aims to replace inefficient regional jets by leveraging existing airport infrastructure and capitalizing on current advancements in battery technology.

Michael Kratsios: Inside the White House's AI Strategy

Michael Kratsios, Luther Lowe

White House OSTP Director Michael Kratos advocates for an AI strategy that prioritizes open-weight models and rejects rigid regulatory thresholds, emphasizing a unified national standard to prevent incumbents from stifling startups. Through the report *A New Golden Age for Science*, the administration proposes shifting federal research funding toward private sector leadership while accelerating scientific breakthroughs via autonomous cloud labs and rapid-grant mechanisms. This approach complements President Trump's executive order on quantum computing and a broader "born free" philosophy that aims to remove barriers for digital technologies while carefully managing specific physical risks.

Chelsea Finn: This is the State of the Art in Robotics

Chelsea Finn

Physical Intelligence has advanced its PI-07 foundation model to achieve general-purpose physical AI capable of zero-shot generalization across diverse appliances and robots without task-specific retraining. By integrating multi-timescale memory and optimized reinforcement learning strategies, the organization significantly improves task throughput and reliability for complex manipulation scenarios like kitchen workflows. Currently deployed by YC-backed companies for real-world applications, these models represent a shift toward "out-of-the-box" generalist agents that can operate autonomously in unstructured environments.

Max Hodak: Average Is Not Good Enough

Max Hodak

Max Hodak, CEO of deep-tech startup Science, details the company's solar-powered retinal prosthesis that successfully enabled a patient to read a 300-page novel following major clinical trials. The discussion outlines Science's operational strategy, which includes the proprietary Helix purchasing platform to accelerate hardware procurement and an Eigenreviews performance system utilizing eigenvector centrality for continuous employee evaluation. Hodak further argues that success in brain-computer interfaces relies on high-speed iteration, mission-driven leadership, and building custom internal tools rather than relying on generic enterprise software.

How To Design In The Agent Era

Stephen Haney, Aaron Epstein

Led by Stephen Haney, Paper is an AI-native design platform currently ranking as the third most-used tool behind Figma and Sketch, utilizing a native HTML and CSS rendering engine to facilitate precise agent collaboration. The application distinguishes itself by treating code as the single source of truth, offering features like direct React component handoff and an MCP server that allows autonomous agents to manipulate local repositories and design canvases. While the team prioritizes human curation to maintain design quality against common AI aesthetic pitfalls, the platform is rapidly evolving into a visual coordination layer for the broader agent ecosystem by integrating tools like Paper Shaders and multi-model image generation.

The Case For Data Centers In Space

Philip Johnston, Mark Mandelmann

Founded by Philip Johnston in 2024 and backed by a $170 million Series A from Benchmark, StarCloud has emerged as YC's fastest-growing unicorn by pioneering orbital data centers to bypass terrestrial energy constraints. The company successfully launched its first satellite in November 2025, deploying custom-modified GPU hardware and thermal management systems to run AI models like Gemini while utilizing automotive-grade components to mitigate radiation risks. With plans to scale to 88,000 satellites by 2028 and deploy high-bandwidth compute for government and hyperscale customers, StarCloud aims to eventually generate terawatts of processing capacity through partnerships with SpaceX and NVIDIA.

Patrick Collison: Is AI Breaking the Lean Startup Playbook?

Patrick Collison, Harj Taggar

Patrick Collison shares his journey from dropping out of college twice to launching Stripe, emphasizing the critical role of retaining "cognitive L1 cache" over reliance on AI tools for deep reasoning. He highlights that while new business formation on Stripe has doubled and AI is accelerating revenue milestones, entrepreneurs should remain wary of decentralization fears and instead focus on solving visceral customer problems like legacy payment friction. Collison concludes by advising founders to build fundamental knowledge of first principles and to assess whether their chosen venture is a cause they are willing to pursue for decades.

Alexandr Wang: “This is a Once-in-a-Civilization Opportunity”

Alexandr Wang, Garry Tan

Alexander Wang discusses his journey from founding Scale AI to leading Meta's Frontier Lab, where he is developing the Muse Spark model to deliver frontier-level AI capabilities at a fraction of the cost. He argues that the immediate future of the industry will be defined by agentic looping and the orchestration of autonomous agents rather than raw model size, predicting a massive expansion in global GDP driven by these technologies. Wang concludes by advising founders to build independent convictions based on first principles while emphasizing that systematic thinking and vision are becoming the scarce resources in an era of abundant computational intelligence.

Sam Altman: "Never a Better Time to Do a Startup"

Sam Altman, Paul Graham, Garry Tan

Sam Altman and Y Combinator highlight an exponential shift in startup capabilities where coding agents reduce development time to mere seconds while hard tech representation in the portfolio surges to 25%. The organization positions itself as a decentralizing force to prevent single-entity control of AI power, explicitly rejecting the "live action role play" mindset in favor of heretical, high-conviction building. Altman warns of safety risks regarding surveillance and model concentration but maintains that widespread founder agency and distributed innovation will ultimately prevent economic collapse or catastrophic safety incidents.

What Actually Makes A Startup Durable

Paul Graham and YC partners outline a strategic framework for navigating the AI era, emphasizing that while AI increases individual productivity by 1,000x, founders must target "hard" problems with durable moats to survive market saturation. The session advises building companies through co-founders who provide essential emotional support rather than just complementary skills, noting that human judgment remains critical for community building and navigating high-stakes pivots. Finally, students are offered over $25,000 in AI credits to neutralize geographical disadvantages, reinforcing the program's focus on rapid execution and deep market engagement over theoretical development.

What Big Tech Missed And How Startups Can Still Win

Alexandre LeBrun, Zuckerberg, Jan, Alex

Ami Labs is raising approximately one billion euros in seed funding to develop foundational world models that train on sensory data rather than text, addressing the limitations of current large language models for robotics applications. Co-founded by Alex K. and Yann LeCun following their shared history at Meta and various startups, the Paris-based company aims to build general-purpose robots capable of operating safely in open environments by solving the compute bottlenecks and latency issues inherent in existing vision-language-action architectures. While the venture tackles the high capital demands of securing thousands of GPUs and top-tier talent, it operates under a strict strategic constraint where failure to deliver visible progress within two years could render the company unsustainable due to the intense external expectations created by the massive funding round.