Latest Interviews
Showing 1186–1196 of 1,196 interview transcripts.
Clear all filters- Y Combinator1h 33m
John Preskill on Quantum Computing
John Preskill, Steven Hawking, Kip Thorne, Craig Cannon
Established by Richard Feynman's early theoretical work, the field of quantum computing has evolved from theoretical challenges in the 1970s to a practical reality enabled by mid-1990s error correction and recent hardware advancements in superconducting and trapped-ion systems. As current devices approach 100 qubits, they are poised to disrupt public-key cryptography through Shor's algorithm while simultaneously offering transformative capabilities in quantum chemistry simulation and materials science. The industry now focuses on bridging these applications through hybrid classical-quantum systems and developing post-quantum security measures to address the imminent threat to existing encryption standards.
- 80,000 Hours2h 17m
#27 - Dr Tom Inglesby on careers and policies that reduce global catastrophic biological risks
Dr Tom Inglesby, Keiran Harris, Rob Wiblin
Dr. Thomas Inglesby of the Johns Hopkins Center for Health Security advocates for integrating catastrophic biological risk planning into existing public health and biosecurity frameworks rather than treating them as separate, siloed endeavors. He emphasizes that while natural pandemics currently pose the highest probability of threat, the rising accessibility of biotechnology necessitates a unified US Biodefense Strategy and sustained funding for initiatives like the Global Health Security Agenda to address both accidental and deliberate misuse. By promoting interdisciplinary training through programs like the Emerging Leaders Fellowship and urging legislative support for dedicated emergency response funds, Inglesby seeks to shift the system from reactive crisis management to proactive, resilient infrastructure.
- 80,000 Hours1h 45m
#26 - Marie Gibbons on how exactly clean meat is made & the advances needed to get it in every store
Marie Gibbons, Natalie Cargill, Keiran Harris, Rob Wiblin
In this 80,000 Hours episode, host Natalie Cargill interviews Marie Gibbons, a GFI research fellow and physiologist who transitioned from veterinary medicine to champion cellular agriculture as the most viable path for global animal protection. Gibbons details the technical progression from harvesting satellite cells to scaling production using suspension bioreactors and plant-based scaffolds, while noting that cost reductions will likely drive market entry within the current year. Although the field faces logistical hurdles regarding media costs and regulatory approval, the discussion emphasizes a strategic industry shift toward specialization and collaboration to achieve cost parity with conventional meat within a decade.
- 80,000 Hours2h 40m
#25 - Prof Robin Hanson on why we have to lie to ourselves about why we do what we do
Robin Hanson, Rob Wiblin, Kevin Simler
Robin Hanson argues that human behavior across education, religion, and charity is driven primarily by subconscious signaling motives to avoid violating social norms rather than by stated functional goals. This evolutionary framework explains why institutions prioritize credentialing and ritual over actual efficacy, creating a disconnect between conscious narratives and the real drivers of reproductive fitness and social status. To address these inefficiencies, Hanson proposes implementing decision markets and "marginal charity" strategies that align individual signaling incentives with tangible societal improvements while bypassing the political resistance of established elites.
- Y Combinator3h 42m
Startup Investor School Day 4 Live Stream
Andy Bromberg, Aaron Harris, Ron Conway, Jeff
The final day of Startup Investor School featured a comprehensive analysis of early-stage investment history by Andy Bromberg, behavioral standards for angel investors presented by Aaron Harris, and a founder-centric investment philosophy from Ron Conway. The session detailed the evolution from traditional venture capital to modern token offerings like ICOs while establishing a strict code of conduct emphasizing reputation, speed, and integrity in deal-making. Ultimately, the event equipped attendees with tools to model SAFE conversions and fostered a network committed to maintaining ecosystem transparency and supporting high-potential founders.
- Y Combinator4h 16m
Startup Investor School Day 3 Live Stream
Elad Gil, Pejman, Jeff Clavier, Andrea, Ali Partovi
Day 3 of the Startup Investor School convened five prominent investors, including Elad Gil, Pejman Nozad, Jeff Clavier, Andrea Zurlo, and Ali Partovi, to dissect critical strategies for market selection, team evaluation, and portfolio construction. The speakers emphasized that successful angel investing requires a 10-year horizon, strict risk discipline regarding net worth allocation, and a service-oriented mindset that prioritizes founder support over immediate financial gains. Key consensus points highlighted the necessity of investing in brilliant founders with big ideas regardless of initial market perceptions, maintaining long-term patience through early-stage losses, and building a personal brand rooted in integrity and operational availability.
- Milken Institute1h 38m
A Conversation with Ray Dalio and Michael Milken
Ray Dalio outlines his journey from a 1960s caddie to the architect of Bridgewater's "idea meritocracy," a philosophy forged after a costly 1982 sovereign debt mistake forced him to prioritize objective disagreement over ego. Drawing on historical cycles like the 1974 market crash and 1937 recession, Dalio warns of current parallels in wealth disparity and pension funding gaps while critiquing Bitcoin as a speculative bubble despite China's engineering strengths. His analysis concludes that future economic resilience depends on radical transparency, automation-ready skills, and recognizing that sustainable wealth is a byproduct of value creation rather than an end goal.
- Y Combinator2h 14m
IPFS, CoinList, and the Filecoin ICO with Juan Benet and Dalton Caldwell
Juan Benet, Dalton Caldwell, Craig Cannon, Dan Galpin, Francesc Campoy, Mark Mandelmann, Mark Blythouse, Mark Mandelbaum, Chris Broadfootnich
Protocol Labs, founded by Juan Bonet, is developing the InterPlanetary File System and its incentivized Layer-2, Filecoin, to transition internet infrastructure from centralized, location-based models to a decentralized, content-addressed network that ensures data sovereignty and censorship resistance. By replacing traditional venture capital with token-based funding models like CoinList, the organization enables long-term open-source research while utilizing Proof of Replication to create a liquid global market for unused storage capacity. This initiative aims to solve systemic inefficiencies in credit assignment and data redundancy, positioning Filecoin as a competitor to major cloud providers while fostering a new economy where protocol contributors are compensated directly through native network value.
- Y Combinator5h 9m
Female Founders Conference 2017
Avni Patel-Thompson, Emily Weiss, Laura Behrens Wu, Padmashree Warrior, Aileen Lee, Elizabeth Lyons, Vanessa Torridilla, Erica, Morgan de Bon, Diane Greene, Kirsty Nathoo, Carolyn Lebe, Anu Hariharan, Adora Chung, Jessica Livingston, Kat
The Female Founders Conference brought together prominent industry leaders like Avital Lee, Kate Winslet, and Aileen Lee to analyze the nine distinct factors that differentiate successful startups from unicorns. Prominent founders from companies such as Poppy, Glossier, and NIO shared case studies on overcoming funding rejections, pivoting from failure, and building inclusive cultures within male-dominated sectors. The event concluded with YC partners debunking common myths about early-stage investment while emphasizing that persistent storytelling and rigorous data preparation are essential for women founders navigating systemic bias.
- Milken Institute1h 36m
Between Debt and the Devil: Money, Credit and Fixing Global Finance
Adair Turner, Mike Clouden, Matt Miller, Lord Adair Turner
Lord Adair Turner, former chairman of the UK Financial Services Authority, argues in *Between Debt and the Devil* that the global economic stagnation following the 2008 crisis stems from a failure to regulate private credit creation, which has shifted predominantly toward real estate speculation rather than business investment. He advocates for radical policy reforms including significantly higher bank capital requirements, strict lending limits on property markets, and the adoption of "overt money finance" to escape persistent low-growth equilibriums. Turner warns that without these structural adjustments and a reintegration of banking realities into macroeconomic models, advanced economies face continued inequality and the risk of social instability.
- Milken Institute1h 40m
Asia Summit 2015 - AIIB and the Evolving Multilateral Lending Landscape
Mike Milken, Lee Kuan Yew, Jin Li-chun, Tommy Koh, Jin Tong, Tadashi Maeda, Clive Kerner, Elena Okorochinko
At a Milken Institute discussion, AIIB President-designate Jin Li-chun outlined the bank's lean, clean, and green operational framework designed to complement existing multilateral development banks in addressing a global infrastructure financing gap of $2 trillion annually. With 57 provisional founding members approved and a target to operationalize by year-end, the institution plans to leverage a 2.5 gearing ratio to reach $250 billion in lending capacity while offering flexible financing stages to bridge the $8 trillion Asian infrastructure demand projected for 2030. Although major economies like the United States and Japan remain cautious, stakeholders including rating agencies and the IFC view the AIIB as a strategic partner capable of enhancing credit quality and mobilizing private capital for sustainable development.