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  1. Goldman Sachs19 min

    Regeneron CEO Dr. Leonard Schleifer on Science-Driven Success

    Dr. Leonard Schleifer, John Waldron

    Founded in 1988 by MD-PhDs Leonard Schleifer and George Yancopoulos, Regeneron rejects top-down target selection to pursue science-driven therapeutics, enduring two decades of losses before achieving profitability in 2011. The company currently employs 15,000 people and markets Dupixent as its flagship treatment for diverse allergic conditions while leveraging genomic data from 3 million individuals to advance research in areas like obesity and cancer. Under Schleifer's unique leadership style that eschews quarterly earnings guidance, Regeneron is expanding its genetic sequencing efforts to 50 million people and integrating AI to refine diagnostic precision without compromising its "do well by doing good" ethical mandate.

  2. Goldman Sachs14 min

    Gold, Oil, and Rare Earths: Commodities on the Move

    Daan Struyven, Alison Nathan, Don Stroyven

    Goldman Sachs analysts outline a market landscape defined by U.K. sanctions on major Russian oil producers, which could raise prices by $20 per barrel if OPEC+ fails to offset the disruption, while simultaneously projecting Brent crude to decline to the mid-$50s by 2026. The report highlights critical supply chain fragilities in the rare earth sector, where China's 92% refining dominance and decade-long Western build-out timelines create geopolitical leverage that investors must hedge. To mitigate these risks, the strategy recommends a structural reallocation toward gold, with a target of $4,900 per ounce, as a primary defense against fiscal debasement and resource weaponization alongside silver's volatile, liquid-dependent profile.

  3. Goldman Sachs25 min

    Navigating Year-End Risks: Tariffs, Credit, AI and More

    Dominic Wilson, Josh Schifrin, Tom

    Panelists Josh Schifrin and Dominic Wilson assessed that U.S. economic stability remains intact despite a peaked credit cycle, projecting Federal Reserve rate cuts to 3% or lower by the end of the year driven by soft labor indicators and benign inflation. While equity valuations for AI leaders and corporate debt levels warrant monitoring, the consensus holds that strong balance sheets prevent a bubble scenario and that market volatility remains largely idiosyncratic rather than systemic. The discussion further noted that fiscal sustainability concerns are currently offset by tariff revenue expectations, allowing the bond market to continue its drift toward lower yields.

  4. Goldman Sachs34 min

    ‘Culture is Everything’: Sixth Street’s Alan Waxman on Flexibility and Alpha

    Alan Waxman, Allison Mass

    In the September 2025 Goldman Sachs Exchange "Great Investors" episode, 6th Street Co-CEO Alan Waxman details how the firm's $115 billion assets under management operate through a unified "one team" culture that avoids silos and prioritizes liquidity management over credit exposure. Waxman outlines strategic advantages including the $30 billion TAL cross-platform vehicle and major investments in affordable housing recapitalization, AI business model dispersion, and the global sports ecosystem. The discussion further emphasizes a rigorous hiring standard that removes high-performing individualists to maintain collective responsibility, ensuring the firm can "face the tiger" during crises while systematically identifying relative risk-reward across asset classes.

  5. Goldman Sachs8 min

    Can the China Rally Continue?

    Stratford Dennis, Chris Hussey

    Stratford Dennis outlines a bullish strategy for Chinese equities and Brazil, anticipating a 30% upside in Chinese tech driven by attractive valuations and a 15% yield advantage in Brazil due to an upcoming interest rate cycle. While policymakers target 5% GDP growth despite US-China trade tensions, Dennis warns that a potential data vacuum from the US government shutdown could eventually widen risk profiles for emerging markets. To capitalize on these conditions, the firm is hedging against trade deal failures and executing specific trades in Brazilian equity upside calls while maintaining a light global position in Brazil.

  6. Goldman Sachs58 min

    10th Annual Goldman Sachs Gives Analyst Impact Fund

    Kunal Shah, Asahi Pompei, Rob Lightfoot, Rishi Sunak, Lena Eberhardt, Kenne Ijekeme, Dr. Alex Dagan, Una Bradley, Cynthia Kahumbura, Gunjan Samtani, Pablo Salome, Edith Cooper, Julian Salisbury, Jim Cramer, Billie Jean King

    Celebrating its tenth anniversary, the Goldman Sachs Gives Analyst Impact Fund concluded its 2024 London finals with judges including Kunal Shah and former Prime Minister Rishi Sunak evaluating proposals that ultimately awarded Jacaranda Health the top prize of $250,000. Four finalist teams representing global initiatives in maternal health, education, conservation, and assistive technology competed for a $550,000 grant pool, with Conservation X-Labs, Let's Get Ready, and Lifelights securing second, fourth, and third place respectively. The event highlighted the program's growth to 1,000 participating analysts in a single year and reinforced its role in cultivating leadership skills while driving significant community impact through technology-driven solutions.

  7. Goldman Sachs20 min

    Making Sense of Weak Job Growth Alongside Solid GDP Growth

    David Mericle, Alison Nathan

    Despite tariffs reaching eight times 2019 levels and a three-week government shutdown subtracting from growth, U.S. GDP resilience is maintained by a depreciating dollar, stable stock markets, and a productivity rebound to historical averages. Core inflation is projected to normalize toward the 2% target as supply chains recover, supporting the Federal Reserve's current expectation of three consecutive 25-basis-point rate cuts through the end of the year. While immigration drops have constrained labor supply and AI adoption remains limited to specific sectors, policymakers anticipate maintaining a moderate expansion path unless post-shutdown data reveals significant deviations from current forecasts.

  8. Goldman Sachs30 min

    Sixth Street CEO Alan Waxman on Sports Investing and Identifying Opportunities

    Alan Waxman, David Solomon

    Founded by former Goldman Sachs leaders to eliminate internal silos, Sixth Street operates as a $115 billion multi-strategy private capital firm utilizing its unique "TAO" vehicle to deploy bespoke solutions across 16 sector teams. The firm distinguishes itself by securing early-entry stakes in high-growth sectors like sports through rapid execution, while rigorously filtering personnel based on a culture of total collaboration rather than individual ego. This organizational model, which prioritizes long-term relationship building and agile risk assessment, allows the firm to navigate complex markets ranging from affordable housing to artificial intelligence without relying on traditional deployment factories.

  9. Goldman Sachs35 min

    ‘The Technology Opportunity of Our Lifetimes’: Bessemer's Byron Deeter

    Byron Deeter, Ken Hirsch

    Goldman Sachs co-chairman Ken Hirsch interviews Bessemer Venture Partners partner Byron Dieter regarding the firm's "empowerment" investment strategy and its aggressive $10 billion allocation toward AI infrastructure and application sectors. Dieter emphasizes prioritizing elite founding teams over ideas while leveraging a platform of 150+ IPOs to syndicate risk, a shift driven by the predicted expansion of Total Addressable Markets from infrastructure to "answer engine" outcomes. The discussion further highlights Bessemer's evolution into a full-service operational support model, exemplified by founder well-being initiatives like STRIVE and a strategic focus on avoiding "crimes of omission" in high-growth markets.

  10. Goldman Sachs11 min

    The Bubble Question

    Chris Hussey, Mike Washington

    Following a trade war-induced volatility spike that triggered a brief S&P 500 drawdown, market resilience was demonstrated by record retail options activity and strong third-quarter earnings from major U.S. banks and luxury firms. Analysts reject systemic bubble narratives, noting that current valuations are supported by genuine earnings growth and projected $520 billion in retail net demand through 2026 rather than irrational expansion. While a modest 5–8% correction is considered plausible before the year-end, the market is underpinned by robust corporate buybacks and upcoming fiscal stimulus expected to sustain consumer spending.

  11. Goldman Sachs19 min

    The Rise of Secondaries: Unlocking Liquidity in Private Markets

    Harold Hope, Alex Blostein, Allison Nathan

    The global secondary private markets reached $650 billion in assets under management with a 15% annual growth rate, driven by $200 billion in projected transaction volumes and shifting demand for liquidity among institutional and retail investors. Market dynamics now favor a 50-50 split between LP-led and GP-led continuation vehicles, as general partners across the top 200 managers increasingly utilize these structures to retain trophy assets and mitigate vintage risk. While a $200 billion supply of dry powder currently creates a favorable supply-demand imbalance, the sector is evolving from a tactical tool to a core allocation strategy expected to accelerate further as turnover rates mature over the next decade.

  12. Goldman Sachs8 min

    Can the Rally Continue?

    Ashok Varadhan, Chris Hussey

    Ashok Varadhan maintains a constructive outlook on U.S. equities, projecting a policy interest rate normalization near 3% within the year and a market consolidation in the fourth quarter before a 2026 resumption. While advising investors to remain long and hedge downside risks through cheaply priced puts during a low-volatility environment, he identifies a structural shift away from fiat currencies into assets like Bitcoin and AI-driven stocks as a response to fiscal expansion. This strategy navigates potential Q4 risks from a government shutdown that delays critical economic data, ensuring the portfolio capitalizes on the enduring technological investment cycle while accounting for tariff absorption and crowded consensus positions.

  13. Goldman Sachs18 min

    The Future of Software Engineering: Cognition’s Russell Kaplan

    Russell Kaplan, Marco Argenti

    Cognition, founded by former Olympiad medalists and now valued at $4 billion, is advancing software engineering by deploying Devin, an autonomous AI agent capable of executing end-to-end development tasks. The company differentiates itself through a dual-product strategy combining Devin for independent execution with the recently acquired Windsurf IDE for human-in-the-loop collaboration, targeting enterprise integration into proprietary codebases. While AI capabilities in coding are projected to double every seven months, Cognition aims to elevate Devin to senior engineer status within a year, though future growth is anticipated to be constrained by energy availability rather than data scarcity.

  14. Goldman Sachs21 min

    The Shutdown’s Economic Impact

    Alec Phillips, Alison Nathan

    A partisan role reversal has precipitated a broad federal government shutdown as Democrats withhold support for clean spending bills to demand the extension of ACA health insurance subsidies, a move that polling suggests is driving voter blame toward Republicans. The crisis faces a critical resolution pressure point on October 15 when active-duty military personnel miss a pay cycle, a deadline that historically compels congressional action to avoid widespread economic disruption. While the shutdown projects to reduce Q4 GDP by approximately 0.3 percentage points and delay key economic data releases, market analysts and the Federal Reserve anticipate the stalemate will resolve quickly through a targeted fiscal compromise.

  15. Goldman Sachs44 min

    Memorial Sloan Kettering Cancer Center’s CEO on the Future of Cancer Treatment

    Selwyn M. Vickers, Brian Robinson, Dr. Selwyn Vickers

    Memorial Sloan Kettering leverages its vast biobank and dual expertise in computational oncology to drive a "golden era" of cancer treatment, where AI-driven predictive models and breakthroughs in immunotherapy have transformed survival rates for aggressive malignancies. Concurrently, the institution confronts rising youth cancer incidence and systemic health inequities by developing accessible genetic screening tools and deploying low-infrastructure immunotherapy protocols globally. These clinical and technological advances are grounded in a leadership philosophy that prioritizes professional excellence to dismantle socioeconomic barriers and improve care access for underserved populations.