Latest Interviews
Showing 1861–1875 of 2,502 transcripts.
Clear all filters- a16z27 min
CRISPR 2.0 and the Future of Gene Therapies
The gene therapy sector is undergoing a paradigm shift from simple transgene addition to precise CRISPR-based editing, driven by recent FDA approvals and a pipeline projecting dozens of Phase 3 trials this year. Despite significant progress in developing base editors and expanding delivery vectors, the industry faces critical bottlenecks in manufacturing scalability and achieving organ-specific targeting without immunogenicity. Successful organizations are distinguishing themselves by combining rigorous engineering mindsets with interdisciplinary teams to optimize modalities and automate production for a future of millions of patients.
- Y Combinator8 min
How To Cold Email Investors - Michael Seibel
Founders are advised to craft concise, six-second cold emails that explicitly detail the problem, solution, traction, and unique market insight without requesting immediate meetings or using storytelling. By sending from verified company domains and attaching standard Silicon Valley pitch decks only if necessary, entrepreneurs can increase the likelihood of initiating a dialogue rather than securing instant funding. Success is determined by measuring open rates through tracking tools and ensuring the message provides raw facts to generate investor interest, avoiding the pitfalls of withholding information or sending excessive follow-ups.
- a16z1h 25m
Making Culture, Making Influence -- Dapper Dan in Silicon Valley
Dapper Dan, Daniel Day, Ben Horowitz
Harlem native Dapper Dan, a self-made entrepreneur who transitioned from 1960s drug trafficking to pioneering "logomania," built a custom luxury fashion empire by adapting high-end brand symbols for the community's elite before facing 1990s legal raids and a near-fatal shooting that devastated his business. Decades of litigation and cultural marginalization were resolved through a 2017 strategic partnership with Gucci, which established the Dapper Dan Atelier to formally acknowledge his design innovations and rectify historical appropriation of his intellectual property. Drawing parallels to African independence movements, Dan now advocates for Black entrepreneurs to integrate into multinational corporate structures rather than operating on the margins, leveraging his unique position to influence global fashion and economic empowerment strategies.
- Milken Institute58 min
The Known Unknowns of Election 2020
Sarah Sandler, Willow Bay, Jim Messina, Mark Penn, Karl Rove, Neera Tanden
A panel of political experts analyzes global anti-establishment trends and U.S. demographic shifts to outline the critical strategies required for the 2020 election. The discussion highlights that both Donald Trump and Democratic contenders must balance voter persuasion with base mobilization to overcome Trump's low personal likability and the primary's intense focus on electability. Key insights reveal that winning will depend on addressing economic anxieties and cultural divisions while navigating a fractured electorate where trust in institutions has severely declined.
- Y Combinator29 min
Kirsty Nathoo - Managing Startup Finances
Founders are advised to track core financial metrics like burn rate and runway weekly to maintain a "default alive" trajectory toward profitability, using tools like Trevor Blackwell's calculator to model realistic scenarios. The presentation warns against underestimating expenses, misclassifying labor costs, or hiring prematurely, emphasizing that scaling before product-market fit significantly increases failure risk. To secure optimal fundraising leverage, founders should aim for sustained revenue growth on existing capital while reserving Series A financing for when detailed forecasts and proven traction are available.
- Milken Institute56 min
A Conversation with Wilbur L. Ross, Jr., Secretary, U.S. Dept. of Commerce | The American Workforce
Wilbur L. Ross, Jr., Gerard Baker, Bernard Harris, Jr., Barbara Humpton, Jonathan Sokoloff, John, Wilbur Ross
The American Workforce Advisory Board, led by Secretary Ross, has secured commitments for 7.5 million apprenticeships to address critical labor gaps caused by a "barbell" demographic and a vocational training deficit. Industry leaders and policymakers are collaborating to shift from a traditional degree-centric model toward merit-based hiring, lifelong retraining, and expanded STEM education to prepare for technological displacement and emerging sectors like space travel. This strategic pivot aims to align the workforce with evolving economic realities by prioritizing digital readiness, soft skills, and streamlined credentialing over obsolete vocational labels.
- Goldman Sachs16 min
Darren Walker – President of the Ford Foundation
Darren Walker, President of the Ford Foundation, leverages his decade of private sector experience in capital markets and law to critique structural inequalities he argues threaten American democracy. Drawing on historical data regarding the "War on Drugs" and post-1982 corporate financial shifts, Walker asserts that systemic designs deliberately suppress upward mobility and erode trust in institutions. He concludes by urging professionals to integrate empathy and specific skill sets into for-profit sectors and local community engagement rather than assuming a full career pivot is necessary for social impact.
- Milken Institute1h 0m
Taking Travel, Leisure, and Transportation to the Next Level
Carol Massar, Michael Flaskey, Glenn Fogel, Josh Giegel, Caryn Seidman-Becker, Rob Wiesenthal
Representatives from Booking Holdings, Clear, Blade, Virgin Hyperloop, and Diamond Resorts detailed industry shifts toward unified digital ecosystems that leverage AI and biometrics to eliminate friction in travel, while simultaneously addressing legacy regulatory hurdles and data sovereignty concerns. The panelists highlighted strategic pivots aimed at younger demographics and mass markets, such as flexible vacation contracts, democratized helicopter transport, and high-capacity hyperloop transit, alongside aggressive plans to deploy infrastructure for future autonomous mobility. Ultimately, the discussion underscored how emerging technologies and adaptive business models aim to transform fragmented travel experiences into seamless, secure, and accessible end-to-end journeys.
- Milken Institute1h 2m
First Step, and Not the Last: Criminal Justice Reform
Nicholas Kristof, Phil Bryant, Susan Burton, Mark Holden, Valerie Jarrett, Nicholas Turner, Clara Wu Tsai, Nick Turner
A bipartisan panel of political leaders, activists, and business executives collectively identifies mass incarceration as a systemic failure, highlighting the specific legislative failures of the 1994 Crime Bill and the limitations of the 2018 First Step Act. Drawing on data from Mississippi's "Fresh Start Act" and private sector initiatives, the discussion details how reforms ranging from expungement laws and Pell Grant restoration to vocational coding programs have successfully reduced prison populations, saved millions in state costs, and slashed recidivism rates. Ultimately, the consensus underscores a strategic shift toward preventative investments in education and early childhood programs to dismantle the racial and economic disparities perpetuated by current punitive policies.
- Milken Institute31 min
A Conversation with Mark Bradford and Michael Govan
Art critic and curator Bradford discusses his evolution from abstract expressionism to politically charged installations that challenge institutional norms and address social inequities. The conversation highlights his co-founding of Art + Practice, a non-profit transforming a former beauty parlor into a hybrid gallery and foster youth center in Leimert Park to serve marginalized communities. Through strategic partnerships with LACMA and a rejection of the "colonizing model," Bradford advocates for an integrated approach where artistic practice drives systemic change and resource redistribution.
- a16z51 min
Founding Stories: Synapse
Sankaet Pathak, Angela Strange
Founded by Sanket Patak after facing banking exclusion as an international student, Synapse operates as a modular infrastructure platform that automates compliance and identity verification for fintechs and traditional institutions. The company resolves complex regulatory barriers by standardizing KYC, AML, and transaction monitoring across multiple partners, effectively replacing labor-intensive manual processes with an AI-driven "autopilot" model. This approach enables non-bank entities to securely launch financial products for underbanked demographics while allowing sponsor banks to mitigate operational risk and scale without linear cost increases.
- Y Combinator58 min
Startup Hiring Advice from Lever CEO Sarah Nahm with Holly Liu
Sarah Nahm, Holly Liu, Craig Cannon, Eva Zhang
Former Google executive Holly founded Lever in 2012 to address the competitive necessity of talent acquisition in the software era, eventually stepping into a CEO role after a rigorous Series A fundraising round in late 2014. The company distinguishes itself through aggressive outbound recruiting strategies that source 81% of engineers and a comprehensive Diversity, Equity, and Inclusion framework that replaces traditional job descriptions with impact-focused assessments. By prioritizing cultural alignment over technical gatekeeping and treating hiring as a core leadership function, Lever has cultivated a high-performing workforce capable of navigating complex remote work dynamics while maintaining strong internal equity.
- Y Combinator1h 1m
Advice on Organizing and Running Growth Teams from Dan Hockenmaier and Gustaf Alströmer
Dan Hockenmaier, Gustaf Alströmer, Craig Cannon, Toni, Michael Savage, Justin LaRosa, Mark Mandelbaum, Francesc Campoy, Dan Galpin, Dan Gallup
Dan Hockenmeyer of Basis One and Gustav Alströmer of Y Combinator discuss a growth strategy centered on prioritizing a single high-leverage channel and achieving product-market fit before scaling paid acquisition. They argue that early-stage teams must rely on analytical generalists who can model the entire business equation, using retention graphs to test high-impact hypotheses rather than chasing superficial metric tweaks. The discussion highlights critical lessons from Airbnb and Thumbtack, emphasizing that sustainable expansion requires building growth functions in-house, treating referrals as paid marketing with strict ROI calculations, and avoiding structural distractions like premature VP hires or reliance on saturated ad platforms.
- a16z30 min
Founding Stories: Anchorage
Chris Dixon, Diogo Monica, Nathan McCauley, Katie Haun
Founders Nathan and Diogo, previously instrumental in scaling security at Square and Docker, established Anchorage Digital to address the operational limitations of traditional cold storage for institutional crypto assets. The firm deploys a crash-resistant custody architecture that enables active on-chain participation, including staking and governance voting, while simultaneously serving as a founding node operator for the independent Libra Association in Geneva. This dual strategy aims to legitimize the broader cryptocurrency ecosystem by combining regulated fiduciary safeguards with a decentralized blockchain designed for global scalability and mass adoption.
- a16z21 min
How to Get the Most from Your Board
This presentation analyzes the critical dynamics of long-term venture capital relationships, emphasizing the need for entrepreneurs to align with board members who serve as strategic stewards rather than mere financial backers. It details how diverging economic interests and fiduciary duties influence three distinct exit scenarios: distress management through recapitalization, acquisition negotiations involving management carve-outs, and IPO processes where pricing conflicts arise. Ultimately, the discussion advises founders to rigorously assess investor incentives and liquidation structures to maintain alignment and build durable, independent public companies.