Latest Interviews
Showing 1936–1950 of 2,502 transcripts.
Clear all filters- Y Combinator52 min
What Shutting Down Your Startup Feels Like - Avni Patel Thompson of Poppy with Kat Manalac
Avni Patel Thompson, Kat Manalac, Craig Cannon, Kat Manialek
Avni Patel-Thompson, the former CEO of the childcare startup Poppy, closed the Seattle-based company in December after three and a half years due to unsustainability in its marketplace economics and a capital runway of only six to eight months. Despite raising over $2 million and validating a unique supply of caregivers, the venture could not overcome the high-margin challenges of scaling from a neighborhood pilot to a larger operation without significant pivot or acquisition. Patel-Thompson executed a transparent wind-down to preserve team morale and investor relationships, describing the shutdown as the successful completion of a hypothesis rather than a personal failure while she transitions to unstructured exploration before her next venture.
- Milken Institute17 min
The Stories We Tell Feat. Jay Shetty
Challenging the triviality of current social media usage, the presentation outlines a strategy to leverage mobile penetration for distributing life-changing wisdom through emotionally resonant storytelling. By transforming passive consumption into active participation, campaigns by National Geographic and mental health initiatives achieved massive global reach, turning viral moments into offline community support and mentorship networks. The proposed framework prioritizes understanding audience pain, integrating entertainment to enhance retention, and enabling co-creation to facilitate implicit learning.
- Milken Institute1h 10m
The Evolution of Leadership
Heidi Toribio, Sharanjit Leyl, Marina Mahathir, Michael Owen, Igor Tulchinsky, John Wood
The Milken Women's Leadership Summit gathered industry leaders like John Wood, Marina Mahathir, and Michael Owen to redefine inclusion as active participation and highlight the fusion of data, artificial intelligence, and human resilience in modern governance. Participants addressed the critical need to democratize financial education through initiatives like WorldQuant University while navigating digital scrutiny and leveraging technology to bypass media restrictions in global advocacy. The session concluded with a consensus that future leaders must balance decisive action with long-term ecosystem building, prioritizing transparency and humility as the ultimate measures of character.
- a16z36 min
a16z Podcast | Dark Data in Healthcare
Susannah Fox, Anil Sethi, Vijay Pande, Sonal Chokshi
A speaker outlines a paradigm shift in healthcare where the legal right of "Portability" under HIPAA transforms patients from passive data recipients into the central hubs of their own longitudinal medical records. This approach addresses the "dark data" gap by leveraging real-world evidence and AI to unify fragmented clinical and non-clinical sources, thereby accelerating chronic disease management and clinical trial matching. Ultimately, the proposal envisions a "permissionless innovation" ecosystem where frictionless data access empowers patients to coordinate care across providers and drive collaborative research.
- a16z59 min
a16z Podcast | The Science and Business of Innovative Medicines
Jorge Conde, Vijay Pande, Sonal Chokshi, Vas Narasimhan
Novartis transformed its portfolio through a $50 billion restructuring that divested consumer healthcare to prioritize advanced therapies, data science, and proprietary platforms for cell and gene treatments. Under CEO Vas Narasimhan, the company enforces strict "standard of care" mandates for project approval, integrates market access early in development, and invested $15 billion to own specialized infrastructure while leveraging AI for financial forecasting and pathology analysis. This strategic pivot targets a 10% clinical success rate by shifting from bespoke drug development to modular platforms and dedicated digital innovation centers, positioning the firm to address undruggable targets and future modalities like xenotransplantation.
- a16z41 min
a16z Podcast | What’s Next for Marketplace Startups (Hint: Services)
Li Jin, Andrew Chen, Frank Chen
A16Z outlines a strategic shift in digital marketplaces toward the "Managed Era," where platforms assume operational control to address the low digital penetration in heterogeneous service sectors. The firm targets regulated industries such as healthcare and mental wellness, advocating for supply expansion through AI automation and redefined licensing to unlock unconsumed demand. This approach anticipates a future where corporate entities replace individual providers in high-trust verticals to ensure scalable, consistent quality.
- Y Combinator59 min
Cindy Mi and Qi Lu Share Advice for Entrepreneurs Building Global Companies
Zhangjiakou-native founder launched VIPKid in 2013 to bridge a massive educational supply gap by connecting over 60,000 North American teachers with Chinese students through a scalable, technology-enabled marketplace. The company rapidly achieved product-market fit by prioritizing rigorous efficacy metrics and a "global from day one" operational model that eventually expanded into a Global Classroom offering Mandarin instruction and AI-integrated personalized learning paths. Driven by a leadership philosophy centering on student and teacher success, the organization now envisions an future where artificial intelligence empowers educators to scale impact while cultivating global citizenship.
- Milken Institute1h 30m
A Conversation with Howard Marks: Mastering the Market Cycle
Investment strategist Howard Marks emphasizes that historical market cycles and human psychology consistently drive asset pricing, challenging the "this time is different" narrative while highlighting the critical importance of valuation over asset quality. His analysis of structural shifts, from the evolution of bond covenants to the rise of passive investing, underscores that risk is cyclically determined by investor sentiment and liquidity rather than economic fundamentals alone. Ultimately, Marks argues that successful capital allocation requires recognizing probabilistic outcomes and maintaining sufficient resources to exploit the extreme fear and pricing inefficiencies that arise during inevitable downturns.
- Milken Institute56 min
Asia's Next Frontier: Building Capabilities for Translational Research
Tanisha Carino, Christiana Bardon, Carl Firth, Annalisa Jenkins, Baiju Shah, Chris Bardone
Faster Cures and Milken Institute convene Asian policymakers and industry leaders to address the critical "Valley of Death" separating basic science from clinical cures across the region's rapidly expanding R&D landscape. The discussion highlights Singapore's strategic shift toward translational funding and data infrastructure, China's accelerated regulatory reforms, and the Harrington Project's hybrid model designed to bridge skill and capital gaps for high-burden diseases. While genomic initiatives and reimbursement changes promise to modernize access, the session concludes that overcoming cultural barriers in patient advocacy and workforce specialization remains essential for translating scientific knowledge into effective patient treatments.
- a16z42 min
What's Next for Education Startups
D'Arcy Coolican, Li Jin, Frank Chen, Lee Jin
The higher education sector is undergoing a structural unbundling that separates skills training, credential signaling, and networking, driven by a student shift toward employment-focused ROI and the rise of specialized startups. New business models such as Income Share Agreements and micro-credentialing are challenging traditional tuition systems, placing vulnerable tier-two universities at risk while elite institutions leverage strong brand moats for defense. This transformation is further fueled by regulatory constraints that favor established accreditors and a global move toward continuous upskilling that disrupts the linear path from college to career.
- Y Combinator35 min
Vinod Khosla : How to Build the Future
Venture capitalist Vinod Khosla asserts that building a billion-dollar company requires a founder to shift from static planning to an adaptive mindset that prioritizes the "kitchen cabinet" and high-caliber talent over short-term revenue stability. He advises allocating at least 30% of equity to attract elite "athletes" with first-principles thinking while rigorously selecting investors who have survived near-bankruptcy to avoid the 90% of advisors who add negative value. Looking forward, this approach aims to reinvent global infrastructure by targeting 100% to 1,000% improvements in sectors like food, construction, and transportation to replicate top-tier living standards for the entire world.
- Milken Institute1h 1m
Investing for the Long-Term
Ian Martin, Sophia Cheng, Azmil Zahruddin Raja Abdul Aziz, Michael Rolland, Tom Tull
Representatives from Texas ERS, OMERS, Kazana National Fund, and Cathay Financial convened to discuss capital management strategies for institutional pools exceeding $700 billion in combined assets. The panelists detailed shifts toward alternative asset allocation and direct private investments to counter demographic aging, low-interest rate environments, and rising market valuations. Key discussions highlighted the tension between strict ESG governance and financial performance, alongside the necessity of avoiding crowded markets through bilateral deal relationships and active risk management.
- Milken Institute1h 1m
Hacking Health: The Future of Humankind
Jeannette Ickovics, Jeremy Cao, Julien de Salaberry, Christopher Hall, Joseph Wong, Lihan Zhou, Chris Hall, Lee Han, Julian DeSalveri, Ritesh Maishuri, Laura Entwistle, Mark Blythery, Dan Galpin
Industry leaders from organizations including Fitbit, BGI, and Meraxis convened to analyze the projected $18 trillion global health spending landscape, with a specific focus on Asia's unique demographic challenges and rapid digital health growth. The event highlighted how strategic innovations in genomics, AI-driven wearables, and early cancer detection are driving a critical shift from curative to preventative care models while navigating complex regulatory environments across diverse Asian markets. Participants emphasized that future success depends on integrating high-tech solutions with empathetic delivery, securing investment through intellectual property and execution speed, and addressing ethical gaps in genetic privacy and mental health.
- Milken Institute1h 1m
Smarter Cities for a Smarter World
Jonathan Woetzel, Hugh Andrew, Nayef Khalid Al Khalifa, Robert Rosenstein, Lauren Sorkin
A recent McKinsey Global Institute analysis reveals that while most global cities currently operate at only 70% maturity regarding smart technology, successful implementation demands a shift from rigid zoning to outcome-based regulation and robust public-private partnerships. Key drivers for this evolution include treating digital infrastructure as a utility, prioritizing human capital through inclusive social policies, and restructuring real estate models to accommodate e-commerce and automated logistics. Ultimately, sustainable urban development relies on strong civic leadership defining long-term visions while ensuring equitable access and clear ROI metrics across diverse markets from North Asia to the Middle East.
- a16z38 min
a16z Podcast | Talent, Tech Trends, and Culture -- with Ben, Marc, and Tyler Cowen
Tyler Cowen, Marc Andreessen, Ben Horowitz
Marc Andreessen and Ben Horowitz detail the founding history of their firm, Andreessen Horowitz, which challenges conventional venture capital wisdom by prioritizing long-term partnerships with extreme founders rather than professional management teams. The partners analyze emerging technological shifts, arguing that blockchain serves as a new trust-based computing platform while predicting a future where retail becomes experiential and wearables enable predictive healthcare. Additionally, they propose integrating Hollywood's emotional talent identification with Silicon Valley's systems thinking through their Cultural Leadership Fund, asserting that the next frontier of innovation lies in automating the selection and funding of high-stakes initiatives.