Latest Interviews

Colossal Biosciences’ Ben Lamm sees ‘de-extinction’ as vital to fighting climate change

Ben Lamm, Amit Sinha, George Church

Co-founded by CEO Ben Lamb and geneticist George Church, Colossal Biosciences leverages multiplex CRISPR editing to restore extinct species like the woolly mammoth as functional tools for Arctic climate mitigation and biodiversity preservation. The company has secured $225 million in funding to execute a for-profit model generating revenue through carbon credits and ecological services, while simultaneously advancing spin-off technologies in artificial wombs and human medicine. By reintroducing megafauna to the Arctic, Colossal aims to lower ground temperatures and store carbon, with subsequent targets including the Thylacine and Dodo to address global ecological voids.

Matthew Prince: The Two Biggest Mistakes Every Founder Makes | E1072

Matthew Prince, Harry Stebbings

Cloudflare co-founder Matthew Prince details the company's strategic evolution from a spam-fighting project to a $19.6 billion enterprise driven by an ambitious vision to "run the internet." Under his leadership alongside co-founders Michelle Zatlin and Lee Holloway, the firm adopted a venture-backed model that bypassed narrow targeting to attract top talent and launched a free tier that inadvertently served high-risk civil society clients. This approach enabled Cloudflare to defend Ukrainian infrastructure against cyber probing in 2022, resulting in sanctions from the Russian government against Prince, Zuckerberg, and Benioff, while cementing the company's focus on massive societal impact and global infrastructure protection.

Dunking in VR: Inside the Future of Sports

Paul Katsen

Meta is launching the Quest 3 mixed reality headset and an AI-powered Ray-Ban partnership in the fall to advance a vision of physically co-locating users in immersive virtual environments. The company prioritizes social retention through interest-based applications like Gym Class VR, leveraging existing hardware and emerging AI capabilities for real-time translation and motion capture to foster personalized 3D interactions. By targeting specific communities rather than generic metaverses, Meta aims to replace low-impact digital experiences with movement-based connectivity that reduces loneliness and supports diverse use cases from gaming to education.

Michael Eisenberg and Adi Levanon: Israeli Resilience in Crisis | E1072

Michael Eisenberg, Adi Levanon, Harry Stebbings

Following an attack causing over 1,400 Israeli casualties and the abduction of more than 100 hostages, the nation mobilized reserve forces and civilians while the tech sector established command centers to coordinate rescue and maintain business continuity. Global venture capital firms and political leaders have rallied to affirm support against Hamas and Iranian threats, despite rising anti-Semitic incidents and perceived equivocation from certain academic institutions. Investors predict that Israel's demonstrated resilience will attract significant capital inflows in the post-conflict era, even as speakers warn that the situation may deteriorate further before eventual improvement.

Grant Sanderson (@3blue1brown) — Past, present, & future of mathematics

Grant Sanderson

Grant Sanderson advocates for redirecting mathematical talent toward practical sectors like logistics and manufacturing through policy-driven collaborations, while arguing that artificial intelligence will achieve Olympiad-level competence without necessarily signaling the arrival of AGI. He distinguishes between online explanation and in-person education, asserting that profound student impact stems from human mentorship and social dynamics rather than algorithmic content or video scaling. Sanderson further attributes breakthroughs in mathematical history to periods of creative freedom and emphasizes that effective learning requires iterative problem-solving and personalized engagement to overcome the "curse of knowledge."

Doctor Gabor Mate: The Shocking Link Between Kindness & Illness!

Gabor Mate

Dr. Gabor Maté characterizes the modern era as an "epidemic of distress," linking widespread emotional repression and childhood trauma to rising rates of autoimmune disease, cancer, and cardiovascular failure through physiological mechanisms. He argues that healing requires individuals to reclaim their "first nature" by expressing healthy boundaries and embracing vulnerability, while simultaneously urging systemic reforms in medical education, child development, and social welfare to address the root causes of suffering. Ultimately, Maté asserts that true health is a state of wholeness achieved by integrating past wounds, which empowers people to foster authentic relationships and serve their communities effectively.

Robert Rubin: The biggest risks to the US economy are political, not financial

Robert Rubin, David, Bob Rubin

Former Treasury Secretary Bob Rubin outlines a philosophy where all decision-making must rely on probabilistic assessments rather than certainties, a principle that guides his assessment of current systemic stability and global risks. He identifies political dysfunction in the United States as the primary threat to the economy, while arguing that governments, not corporations, must lead the transition on climate change and international cooperation with China. Drawing from his decades at Goldman Sachs, Rubin emphasizes that sustainable success requires intense focus balanced with institutional support for employees to navigate an uncertain future where guarantees are nonexistent.

Roundtable #4 with Jason Lemkin, Woody Marshall, Deven Parekh, Harry Stebbings | E1071

Jason Lemkin, Woody Marshall, Deven Parekh, Harry Stebbings

The current enterprise software market reflects a structural shift toward profitability and efficiency, characterized by a deal drought driven by valuation gaps and a slowdown in late-stage private funding. While recent activity includes the Cisco-Splunk acquisition and several scaled public offerings, the sector anticipates an IPO window reopening in late 2024 as investors prioritize free cash flow and normalized multiples over hyper-growth. Amidst cautious optimism regarding artificial intelligence adoption, firms like Insight and TCV are navigating capital needs with a focus on profitable growth assets and secondary liquidity rather than speculative valuations.

Scott Farquhar: Founding Atlassian; How We Scaled to a $50B Valuation; The 4 Jobs of a CEO | E1070

Scott Farquhar, Harry Stebbings

Atlassian co-founders Scott Dunn and Mike Cannon-Brookes built the company from 2001 to 2011 by bootstrapping through the dot-com crash and post-9/11 era, eventually securing a $60 million funding round at a $405 million valuation by utilizing a closed-envelope bidding strategy. Following a decade of independent growth that reached 11,000 employees and 250,000 customers, Dunn identifies past mistakes of omission regarding Bitbucket and Stride as catalysts for launching the new "Point A" incubation program to aggressively invest in emerging categories like AI and developer tools. The organization now operates as a fully remote-first entity leveraging historical data for strategic AI integration, with a vision to eliminate busy work and redefine team collaboration by 2033.

Airbnb CEO: “Airbnb Was Worth $100 BILLION & I Was Lonely & Deeply Sad!”

Brian Chesky, Daniel Ek

Facing an 80% revenue collapse during the 2020 pandemic, CEO Brian Chesky led Airbnb through a radical restructuring and 25% workforce reduction while prioritizing employee support over immediate financial gain. This principle-based crisis management enabled the company to recover, execute a massive IPO in December 2020 with a $100 billion valuation, and fundamentally pivot its strategy from selling spaces to fostering human connection. Chesky's leadership evolution, rooted in industrial design principles and a long-term "decade" perspective, redefined the organization's culture to address societal loneliness through a unified, people-centric global community.

Startup Experts Reveal Their Top Productivity Advice

This presentation asserts that successful startup founders must act as 10x multipliers by rigorously prioritizing direct customer discovery over "fake work" like building complex internal tools or optimizing lifestyle habits. Through techniques such as stack ranking tasks to focus exclusively on the top three priorities and isolating "maker schedules" for deep work, founders are advised to reject distractions and non-essential requests to achieve genuine product-market fit. Ultimately, the core lesson emphasizes that sustainable growth relies on the founder's self-awareness in identifying their unique strengths and their disciplined refusal to engage in multitasking or superficial productivity hacks.

The Evolution of the Satellite Economy

John Gedmark

Astronis Co-founder John Gedmark is capitalizing on a 41-launch surge in the 2022 space sector to deploy a constellation of small satellites in the high-value geostationary orbit, addressing the global connectivity gap for 4 billion unconnected people. The company leverages advanced propulsion and electronics to solve the backhaul problem for remote infrastructure while countering national security risks through a resilient swarm strategy. Following its inaugural 2022 launch, Astronis is accelerating its Falcon 9-based deployment schedule to establish a scalable economic inflection point for orbital internet and prepare for future lunar logistics.

Are we risking nuclear war by supporting Ukraine?

Sarah C.M. Paine

The speaker argues that NATO expansion addresses the genuine security aspirations of Eastern European nations seeking to escape Soviet domination, contrasting their rising living standards with Russia's resource-dependent stagnation. Asserting that Russian aggression stems from a lack of exit strategies rather than strategic brilliance, the analysis rejects nuclear blackmail and frames the conflict as a decisive test where local populations must bear the primary burden of fighting. The proposed resolution involves refusing recognition of occupied territories to permanently isolate Russia, effectively allowing it to mirror North Korea's status while reinforcing that superior alliances lead to victory.

The Food Doctor: Extra Protein Is Making You Fatter!? 6 Food Lies Everyone Still Believes!

Dr Tim Spector, Zoe, Steven

An expert analysis reveals that most healthy adults consume excessive protein and insufficient fiber, creating a public health crisis driven by aggressive supermarket marketing of ultra-processed foods. The event redefines key nutritional habits by debunking myths surrounding supplements and exercise-based weight loss, while highlighting the critical role of dietary diversity and specific food choices like coffee in supporting gut microbiome health. Ultimately, the presentation underscores that shifting toward whole-food diets and personalized nutrition strategies is essential to mitigate the £60 billion annual economic burden imposed by diet-related chronic diseases in the UK.

Matt Rosenberg: Why You Should Not Hire Sales Leaders From Big Companies | E1068

Matt Rosenberg, Harry Stebbings

Former lawyer-turned-sales leader Matt outlines how accidental sales leaders from law and finance can build scalable enterprise motions by prioritizing discovery and "radical listening" over generic playbooks. He advises founders to hire senior operators capable of translating market needs into repeatable processes, quantify the economic cost of delay to drive urgency, and balance product-led growth with dedicated enterprise expansion strategies. Ultimately, the event emphasizes using data to diagnose rep performance, maintaining strict discount discipline, and diversifying leadership teams to include empathetic parents who excel at multitasking and time management.