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  1. Milken Institute35 min

    A Conversation with FDA Commissioner Scott Gottlieb

    Scott Gottlieb

    Former FDA Commissioner Scott Gottlieb outlines a multifaceted regulatory strategy addressing the opioid epidemic, tobacco addiction, and the aftermath of Hurricane María on Puerto Rico's critical medical manufacturing sector. He emphasizes adapting regulatory frameworks for emerging technologies like artificial intelligence and digital health tools while prioritizing the prevention of medical misinformation and product shortages. The discussion highlights a shift toward reducing review cycles, de-risking early-stage development, and utilizing post-market surveillance to balance safety with innovation.

  2. Milken Institute34 min

    A Conversation with PepsiCo CEO Indra Nooyi

    Indra Nooyi, Michael Milken, Andrew, Mike

    PepsiCo CEO Indra Nooyi transformed the beverage and snack giant through "Performance with Purpose," a strategy that integrated social and environmental sustainability into core operations while shifting the revenue portfolio toward healthier product lines. This cultural overhaul was driven by scientific leadership under Chief Scientific Officer Dr. Mahmood Khan and reinforced by tying executive compensation to specific nutritional and environmental goals. Nooyi further extended the company's impact by forging partnerships with healthcare institutions to improve access for underserved veterans and advocating for systemic policy changes to address chronic disease and nutritional equity.

  3. Y Combinator1h 3m

    Experiments in Art and Technology with Artforum Editor Michelle Kuo

    Michelle Kuo, Kat Mañalac, Craig Cannon

    Founded in 1966 by artist Robert Rauschenberg and Bell Labs scientist Billy Kluver, Experiments in Art and Technology (EAT) established a non-hierarchical network connecting thousands of creators with engineers to merge artistic vision with specialized technical expertise. The organization executed large-scale interdisciplinary projects such as the 1970 Osaka Pepsi Pavilion and the "Automation" townhouse, which utilized military-grade infrared technology and broadcast systems to test new forms of performance and labor relations. Despite facing criticism for their ties to the military-industrial complex and eventual project failures due to budget disputes, EAT's legacy endures through its pioneering of site-specific, portable technology works that influenced subsequent corporate art programs.

  4. Goldman Sachs19 min

    Talks at GS – Edward Norton: Capitalism and Creative Disruption

    Edward Norton

    In a discussion spanning his activist family lineage and career in entertainment, actor Edward Norton analyzes the necessity of treating ecological services as a financial asset class to drive sustainability. He contrasts the late-1990s studio system's willingness to risk new voices, exemplified by *Fight Club*, with the modern disruption caused by streaming services that have dismantled traditional DVD revenue models. Norton further details his transition to founding EDO, a data science firm applying finance-grade ROI analytics to media to replace outdated engagement metrics and align ad spend with actual audience action.

  5. Y Combinator1h 13m

    Content Marketing Tips from Experts at First Round Capital and Andreessen Horowitz

    Camille Ricketts, Sonal Chokshi, Craig Cannon

    First Round Capital and a16z articulate a content philosophy that prioritizes strategic metrics and deep, long-form storytelling over vanity traffic, utilizing an editorial instinct honed through pattern recognition. These firms deploy a rigorous production workflow ranging from a three-tier interview framework to the use of "maker schedules" that protect creative energy while balancing reactive news with enduring "stock" projects. Their approach to audience growth relies on identifying niche "true fans" and leveraging proprietary data narratives to ensure utility, rejecting shallow advertorials in favor of authentic, emotionally resonant, or tactical advice.

  6. Milken Institute1h 38m

    A Conversation with Ray Dalio and Michael Milken

    Ray Dalio, Michael Milken

    Ray Dalio outlines his journey from a 1960s caddie to the architect of Bridgewater's "idea meritocracy," a philosophy forged after a costly 1982 sovereign debt mistake forced him to prioritize objective disagreement over ego. Drawing on historical cycles like the 1974 market crash and 1937 recession, Dalio warns of current parallels in wealth disparity and pension funding gaps while critiquing Bitcoin as a speculative bubble despite China's engineering strengths. His analysis concludes that future economic resilience depends on radical transparency, automation-ready skills, and recognizing that sustainable wealth is a byproduct of value creation rather than an end goal.

  7. Y Combinator59 min

    Mr. Robot's Co-Producer and Writer - Kor Adana

    Kor Adana, Craig Cannon

    Former cybersecurity engineer turned television writer Sam Esmail, leveraging his real-world hacking experience to ensure technical authenticity in the series *Mr. Robot*, transitioned from corporate security to Hollywood by funding an unpaid entry with a three-year savings runway. His personal history of exploiting a school AS/400 system directly inspired the character Elliot Alderson, while his rigorous production methodology involves practical, pre-scripted animations and historical software verification to avoid syntax errors. Beyond the screen, this collaboration extended to complex Alternate Reality Games that integrated real-world puzzles and community engagement, blending the creator's expertise in network security with narrative demands to demystify technology for a global audience.

  8. Goldman Sachs23 min

    Talks at GS – Ambassador Christopher Hill: Then & Now – The North Korean Nuclear Crisis

    Christopher Hill

    North Korea has shifted from historical negotiation attempts to a strategy under Kim Jong-un that legally enshrines nuclear weapons to decouple U.S. forces from its allies while developing solid-fuel missiles capable of threatening the American mainland. Addressing this evolving threat requires a multi-pronged approach combining stringent U.S.-led sanctions, cyber operations, and renewed diplomatic efforts, all while navigating China's internal conflict between economic interests and security fears of regime collapse. Without sustained global cooperation and military reassurances for South Korea and Japan, the risk of miscalculation remains high as Pyongyang continues to advance its nuclear capabilities.

  9. Y Combinator49 min

    Communicate with Users, Build Something They Want - Ryan Hoover of Product Hunt

    Ryan Hoover, Craig Cannon

    Ryan Hoover secured Y Combinator investment by validating Product Hunt through manual outreach and email lists before engineering resources were committed, eventually launching the platform as a global hub for product discovery. The company is now shifting its strategy to monetize by introducing the "Ship" paid tool for creators while expanding its angel fund "Weekend Fun" to invest in remote work and voice technology. Operating a distributed team of 17 across nine time zones, Product Hunt focuses on asynchronous collaboration and strategic pivots like dropping podcast discovery to align with its core product recommendation model.

  10. Goldman Sachs11 min

    Talks at GS – Nitin Nohria: The Responsibility of Leadership

    Nitin Nohria, Lloyd

    Harvard Business School has evolved from a domestic management focus into a global leadership institution defined by its mission to cultivate individuals with both professional competence and the character to inspire trust. Dean Nitin Nohria emphasizes that this dual focus is critical to avoiding organizational fragility while asserting that profitable, self-sustaining enterprises offer a superior path to social dignity than traditional philanthropy. This strategic shift aligns with changing student demographics who increasingly prioritize meaningful impact and work-life balance, often favoring smaller firms over large corporations to mitigate perceived institutional risks.

  11. Milken Institute40 min

    Women Leaders’ Summit:A Conversation with Al Gore: How to Inspire a Movement

    Al Gore, Anna Marrs

    At a Milken Institute Women's Summit, former Vice President Al Gore discussed his 2000 election concession, his journey into climate advocacy, and the urgent drivers of the current ecological crisis during the screening of *An Inconvenient Sequel: Truth to Power*. Gore highlighted how rapid technological cost reductions and shifting investor priorities are accelerating a global transition toward electrification and renewables in major economies like India and China, while emphasizing that diverse perspectives and authentic passion are critical for effective communication. The event concluded with a call to action for the investor community to leverage capital and inclusive leadership to secure a sustainable future against the backdrop of a rapidly warming planet.

  12. Y Combinator53 min

    Don't Start a Blog, Start a Cult - Mr. Money Mustache

    Mr. Money Mustache, Pete Adeney, Craig Cannon

    The speaker redefines successful social organizations as structures built on shared values and distinct identities, explicitly citing Elon Musk's engineering-focused leadership as a prime example of such a community. This analysis of "cult" dynamics extends into practical strategies for economic resilience, advocating for radical housing and vehicle reduction, aggressive savings rates, and the development of diverse production skills to insulate individuals from systemic financial shocks. Ultimately, the framework promotes a "first principles" lifestyle where happiness is derived from physical health, genuine social connection, and solving complex problems rather than adhering to traditional consumption norms or rigid long-term planning.

  13. Y Combinator1h 0m

    Your Whole Goal Is to Not Quit - Courtland Allen of Indie Hackers

    Courtland Allen, Craig Cannon

    Following a strategic acquisition by Stripe, the IndieHackers founder shifted operations from ad-revenue management to exclusive community development by launching a podcast that prioritizes radical financial transparency. This platform facilitates high-volume interviews with independent founders like Julian Shapiro and West Boss, showcasing profitable bootstrapped models as a viable alternative to venture-backed growth. The initiative leverages a standardized interview workflow and a self-policing forum ecosystem to document real-world struggles, ultimately fostering a global network of solo entrepreneurs who reject traditional "mission-driven" narratives in favor of sustainable revenue.

  14. Goldman Sachs11 min

    Talks at GS – Richard Armstrong: Redefining Beauty Through Art

    Richard Armstrong

    Since 2008, Director Richard Armstrong has steered the Solomon R. Guggenheim Museum toward a mission prioritizing imagination and the human "quest for beauty" within Frank Lloyd Wright's iconic spiral structure. The institution attracts over one million annual visitors who engage with a curatorial model that rejects rigid data-driven education in favor of challenging, high-risk artistic proposals vetted through a hierarchical directorship process. This approach positions the museum as a sanctuary for eccentricity, aiming to foster visual acuity and societal diversity against the backdrop of modern digital consumption.

  15. Goldman Sachs21 min

    Talks at GS – Tony Blinken: Diplomacy: The First Response

    Tony Blinken

    Former Deputy Secretary of State Tony Blinken outlines a foreign policy philosophy where robust diplomacy serves as the essential first response to prevent conflicts from escalating into costly military engagements. He details critical assessments of recent U.S. strategies, noting that the Iran Nuclear Deal effectively delayed nuclear threats while criticizing the withdrawal from that agreement as a strategic error. Blinken further emphasizes that effective statecraft requires balancing humility regarding intervention limits with a commitment to American values of dignity, as seen in his reflection on the failures in Syria and the complexities surrounding North Korea and China.