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  1. All-In Podcast1h 15m

    Sheryl Sandberg, plus open-source AI gene editing explained

    Sheryl Sandberg, Dave Goldberg, Chamath, Friedberg, TheZachEffect, Jason Calacanis, David Sacks

    Hosts Chamath Palihapitiya, Jason Calacanis, and David Sacks interview Sheryl Sandberg about her documentary *Screams Before Silence*, which utilizes survivor testimony to combat denialism regarding sexual violence committed by Hamas on October 7th while critiquing the silence of feminist organizations and university policies. The conversation also pivots to Profluent Bio's open-sourced AI-designed gene editing tool, Open CRISPR-1, which the hosts argue could democratize biotechnology by bypassing restrictive intellectual property landscapes and accelerating innovation in life sciences. Throughout the episode, the hosts balance a tribute to the late Dave Goldberg with substantive debates on war crimes documentation and the economic potential of open-source biological models.

  2. All-In Podcast1h 41m

    E101: Ye acquires Parler, Snap drops 30%, macro outlook, VC metrics, valuing stocks & more

    Brad Gerstner, Sacks, Ye, Chamath, Gavin Newsom, David Friedberg, Jason Calacanis, Jake

    Panelists analyzed Kanye West's acquisition of the unstable social network Parlor amid his public mental health crisis, sparking debate on media ethics regarding amplifying harmful rhetoric versus platform fragmentation. The discussion expanded to broader market dynamics where rising interest rates are forcing corporate discipline and valuation resets across Meta, Snap, and the venture capital sector. Additional topics included California's contentious Prop 30 tax measure and cultural critiques of consumer behavior regarding alternative proteins and default service options.

  3. All-In Podcast1h 39m

    E92: Adam Neumann's second act, a16z's $350M bet, housing policy, Inflation Reduction Act & more

    Adam Neumann, Chamath, Phil Hellmuth, Dave Friedberg, David Sacks, Jason Calacanis

    Moderator Dave Friedberg publicly apologized to co-host J. Cal to address recent interpersonal friction while the quartet analyzed Adam Neumann's $350 million Flow Fundraising deal and debated the geopolitical implications of China trading oil in yuan. The panel dissected California's housing crisis, scrutinized the Inflation Reduction Act's economic mechanics and IRS enforcement strategies, and examined legal precedents surrounding the Mar-a-Lago raid. Throughout the episode, the hosts balanced professional growth with personal conflict, ultimately reaffirming their commitment to the show's continuity despite diverging views on zoning, foreign policy, and pharmaceutical pricing.

  4. All-In Podcast1h 28m

    E59: Twitter's content warning algo, equity audits, politicians trading stocks, Fed's next move

    Elizabeth Warren, Elon, Jeremy Strong, London Breed, Jason Calacanis, David Sacks

    In a recent episode of the "All In" podcast, Chamath Palihapitiya, David Sacks, and their co-hosts address the Federal Reserve's accelerated tapering plan while critiquing House Democrats' proposed racial equity audits as paternalistic grifts that threaten innovation. The panelists also analyze Omicron's high transmissibility against lower severity, predicting a political shift away from strict lockdowns as the pandemic becomes endemic, and discuss the burgeoning mainstream potential of mRNA technology for treating cancer. Furthermore, the discussion covers emerging tensions in tech moderation, bipartisan failures in congressional insider trading enforcement, and the potential for a "red wave" in the 2022 midterms driven by voter fatigue with radical progressive policies.

  5. All-In Podcast1h 21m

    E28: Current state of public & private markets, Archegos debacle, US debt issues, wealth tax & more

    Chamath, Friedberg, Biden, David Sachs, Jason Calacanis

    In a comprehensive market overview, analysts detail the SPAC bubble's contraction characterized by deal retrading and a valuation surge in the private sector, while simultaneously examining the $20 billion Archegos collapse caused by hidden derivative leverage. Broader macroeconomic discussions highlight the U.S. debt-to-GDP ratio exceeding 130% amidst massive fiscal spending proposals, alongside political debates on wealth taxation and the philosophical tension between freedom and equality. The session concludes with public health updates on vaccine efficacy and logistical announcements regarding upcoming live events and a collective four-way investment by the podcast hosts.

  6. All-In Podcast1h 23m

    E18: Inauguration talk, breaking down the $1.9T stimulus, the case for recalling Gavin Newsom & more

    Gavin Newsom, Chamath, Friedberg, Jason Calacanis

    Hosts David Sacks, David Friedberg, and Chamath Palihapitiya analyze the post-inauguration landscape, warning that Biden's failure to validate opposing viewpoints risks widening political divides while urging against a "domestic Patriot Act" that could empower surveillance over domestic dissent. The discussion shifts to tech governance, where the panel critiques the Facebook Oversight Board's lack of sovereignty and advocates for Common Carrier regulations to prevent Big Tech from becoming quasi-utilities, alongside a sharp critique of California's governance that predicts Governor Gavin Newsom's recall due to failed pandemic policies and talent migration. Finally, the group addresses economic stimulus and wealth inequality, proposing a biomanufacturing infrastructure plan and universal savings accounts to avert a debt crisis, while condemning cancel culture mechanisms that silence free discourse regardless of political affiliation.