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Dave Goldberg

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  1. All-In Podcast1h 15m

    Sheryl Sandberg, plus open-source AI gene editing explained

    Sheryl Sandberg, Dave Goldberg, Chamath, Friedberg, TheZachEffect, Jason Calacanis, David Sacks

    Hosts Chamath Palihapitiya, Jason Calacanis, and David Sacks interview Sheryl Sandberg about her documentary *Screams Before Silence*, which utilizes survivor testimony to combat denialism regarding sexual violence committed by Hamas on October 7th while critiquing the silence of feminist organizations and university policies. The conversation also pivots to Profluent Bio's open-sourced AI-designed gene editing tool, Open CRISPR-1, which the hosts argue could democratize biotechnology by bypassing restrictive intellectual property landscapes and accelerating innovation in life sciences. Throughout the episode, the hosts balance a tribute to the late Dave Goldberg with substantive debates on war crimes documentation and the economic potential of open-source biological models.

  2. All-In Podcast1h 39m

    #AIS: Bestie AMA with Valor's Antonio Gracias

    Antonio Gracias, Chamath, Calacanis, Friedberg, TheZachEffect, David Sacks, Glenn Greenwald, Bill Lee, Jeff Skoll, Dave Goldberg, Tony Hsieh, Chase Coleman, Brad Gerstner, Vinod Khosla, Michael Schellenberger, Andrew Yang, Elon Musk, Steve Jobs, Tim Cook, Samantha, Bobbin, Science Boy, Ted, Mike, Chris, Sarah, Joanna, Kate, Aria, Kenneth Brown III, Sonny Lampa, Prem, Phil Deutsch, Jan, Matthew, Elizabeth Holmes

    Antonio García Martínez and his investment partners argue that American manufacturing resilience depends on prioritizing Return on Invested Capital over revenue multiples, citing Tesla's operational necessity for onshoring as a counter to the short-term cost-cutting that drove industrial decline. This philosophy, forged through high-stakes poker networks and tested by a 2008 existential bet on Tesla and SpaceX, drives their current advocacy for a neutral energy policy and a macroeconomic outlook anticipating a brief recession followed by a capital market reset to pre-2020 valuation norms. By rejecting commoditized hardware markets and financial engineering in favor of high-barrier innovations, the group predicts a mini-retooling era where biomanufacturing and in-person collaboration define the next cycle of value creation.