Latest Interviews

BillionToOne Is Solving One of Biotech’s Hardest Problems

Jared Friedman, David Tsao, Oguzhan Atay

Billion to One, founded by PhD students Oguzhan and David, leverages proprietary synthetic DNA methods to detect rare cell-free DNA variations for prenatal screening and cancer liquid biopsies. Since its public listing with a valuation over $4 billion, the company has scaled its automated facility to process 600,000 tests annually and launched North Star Select for late-stage cancer treatment guidance. The firm now executes a strategic roadmap to address early-stage cancers through a capital-efficient progression from commercial adoption to population-wide screening, aiming to significantly reduce cancer mortality rates.

This Startup Catches Fraud at Scale

Jared Friedman, Karine Mellata

Variance has officially exited stealth mode following a $21 million Series A round to commercialize AI agents that automate trust and safety infrastructure for Fortune 500 clients like GoFundMe and IAC. Founded by ex-Apple engineers Karine and Michael, the 12-person team leverages a unique "agentic" architecture to solve complex unstructured data problems in fraud detection and compliance without manual rule updates. Despite a 2024 leadership injury that threatened operations, the company is scaling its full-stack decisioning platform to replace traditional human review workflows with adaptive, self-healing systems designed to trace sophisticated abuse graphs.

AI Is Unlocking Millions Of New Builders

Mukund, Madhav Jha

Led by twins Mukund and Madhav Jar, Emergent is a YC Summer 2024-funded platform that empowers non-technical users to generate production-ready software through AI agents, having already built seven million apps across 190 countries. The company differentiates itself by utilizing a custom Kubernetes infrastructure and multi-agent architecture to solve the "it works on my machine" problem, while its core team achieved top-tier status on the SWE-bench benchmark within two months. By pivoting from automated testing to full-stack application development, Emergent has democratized software creation, allowing solopreneurs to launch functional products for thousands of dollars instead of the traditional half-million-dollar cost.

The Future Of Brain-Computer Interfaces

Max Hodak, Garry

Science co-founder Max Hodak outlines a biotechnology roadmap centered on the Prima retinal implant, which has already restored form vision to over 40 patients with macular degeneration, and predicts an imminent "takeoff era" that could enable the first 1,000-year lifespans. Beyond vision restoration, his company is developing bio-hybrid neural interfaces that integrate stem-cell-derived neurons into the brain and portable "Vessel" perfusion systems to revolutionize organ preservation and treat severe disabilities like glaucoma. These initiatives aim to shift healthcare from slow drug discovery to precise neural engineering, potentially achieving high-bandwidth human-AI integration within the next two decades.

The Powerful Alternative To Fine-Tuning

Ian Fischer, Mark Mandelbaum, Francesc Campoy Flores, Mark Mandelmann, Jr.

Poetic, led by co-CEO Ian Fisher, deploys a recursive Meta-System that autonomously optimizes foundation models to outperform them on benchmarks like Arc AGI v2 and the Humanity's Last Exam at a fraction of the cost. This stealth-stage platform functions as a cost-effective "stilts" for startups, achieving 9 percentage point gains over competing models while utilizing a lean team of seven scientists rather than massive training budgets. The company now invites early access from ventures seeking to integrate these self-improving reasoning strategies into their specific verticals.

The AI Agent Economy Is Here

Founders and non-technical CEOs are rapidly adopting autonomous AI workflows, creating a parallel "agent economy" where software selection is driven by swarm intelligence rather than human developers. This shift forces a strategic pivot for developers, requiring tools to offer superior, structured documentation and open APIs to be chosen by autonomous agents as primary decision-makers. Industry leaders like Maltbook and Supabase are capitalizing on this transition, while institutions like Y Combinator begin redefining their frameworks to support a future where agents act as the primary economic actors choosing infrastructure.

Inside Claude Code With Its Creator Boris Cherny

Boris Cherny, Mark Mandelmann, Jr., Francesc Campoy, Melanie Warrick

Anthropic has accelerated its engineering velocity to a 150% growth rate by leveraging *Claude Code* to generate 70% to 90% of its own source code and rewriting its entire codebase every six months to avoid technical debt. The organization operates a bimodal workforce of specialists and generalists while predicting that traditional software engineering roles will fade as AI automates coding tasks. With *Claude Code* now powering the majority of developer sessions and influencing 4% of public industry commits, the company is simultaneously expanding into non-technical domains through *Co-work* and monitoring its safety rating at ASL 3.

The New Way To Build A Startup

Garry

Companies such as GigaML, Legion Health, and PhaseShift are redefining operational scale by automating all internal workflows—from code integration to clinical operations—rather than merely augmenting isolated functions. This "20X company" model enables lean teams of just a few employees to service Fortune 500 clients and achieve fourfold revenue growth while maintaining flat headcounts that would traditionally require hundreds of staff. By treating internal processes as the primary product, these organizations achieve AGI-level productivity, allowing them to compete directly with massive incumbents without the corresponding payroll burdens.

OpenClaw Creator: Why 80% Of Apps Will Disappear

Raphael Schaad, Peter Steinberger

Launched in 2025, the open-source OpenClaw project has rapidly accumulated over 160,000 GitHub stars by introducing a local-executing personal AI agent capable of autonomously controlling hardware and synthesizing private data. Creator of the "swarm intelligence" philosophy, the project distinguishes itself through a unique security architecture that isolates user memory in local markdown files and employs a proprietary `soul.md` file to maintain core personality traits against external manipulation. As the technology evolves toward multi-agent negotiations and the obsolescence of traditional applications, OpenClaw positions itself as a value-retention model where specialized bots manage distinct domains while the primary asset remains the user's locally stored data memory.

We're All Addicted To Claude Code

Calvin French-Owen

Industry analysis indicates a decisive shift toward Command Line Interfaces as the primary interaction layer for coding agents, with Anthropic's Cloud Code utilizing subagent models and OpenAI's Codex employing periodic compaction to manage context windows. Senior engineers are increasingly adopting a managerial role to direct autonomous workflows, while top-tier practitioners distinguish themselves by enforcing rigorous testing protocols and minimizing codebase noise to prevent model degradation. This evolution fosters a tension between rapid, bottom-up grassroots adoption driven by speed and enterprise-mandated top-down security controls, fundamentally reshaping software development structures toward smaller teams operating under vast agent armories.

Why Your Startup Website Isn't Converting

Jorn van Dijk, Aaron Epstein

Jorn van Dijk conducted a comprehensive usability audit of five AI startups—Lumari, Ally, Juicebox, Leaping AI, and The Hog—identifying critical friction points where visual complexity and premature calls to action hindered user understanding. The analysis revealed a consistent pattern of missing product proof, such as abstract illustrations or generic templates, which prevented prospects from validating value propositions before encountering mandatory sign-up walls. Recommendations focus on replacing decorative animations with functional UI demonstrations, clarifying enterprise-level scope through targeted visuals, and streamlining messaging to ensure immediate alignment between brand identity and the specific B2B solutions offered.

Inside The Startup Building Reusable Rockets

Aaron Epstein, Andy Lapsa, Tom Feldman

Stokes Space, founded in 2019 by former Blue Origin engineers Andy and Tom, is developing the Nova two-stage rocket to achieve full reusability for both orbital stages and drastically reduce launch costs. Backed by nearly $1 billion in funding and operating from a 168,000-square-foot factory in Kent, Washington, the company plans to execute its first orbital launch later this year from Historic Complex 14 in Florida. The team aims to establish daily launch cadence and ubiquitous space access by integrating in-house manufacturing with a proprietary software platform to manage rigorous testing and FAA-regulated operations.

How Intelligent Is AI, Really?

Diana Hu, Greg Kamradt, François Chollet

The ARC Prize Foundation, guided by François Chollet's definition of intelligence as efficient novelty, is advancing its benchmark through the upcoming interactive Arc AGI v3, which removes all textual instructions to test agent generalization via video game-like environments. Major industry players including OpenAI, xAI, Google, and Anthropic have adopted the benchmark as a standard metric, though the Foundation explicitly warns that high scores alone do not constitute AGI and emphasizes efficiency in data and energy consumption over simple accuracy. The organization maintains a rigorous stance that true artificial general intelligence will only be declared when systems demonstrate human-level adaptability and efficiency, immediately analyzing any system achieving perfect benchmark scores for potential overfitting rather than accepting them as a final milestone.

From Pivot Hell To $1.4 Billion Unicorn

James Hawkins, Brad Flora

PostHog has secured a $75 million Series E round at a $1.4 billion valuation to fuel aggressive workforce expansion from 70 to 200 employees and accelerate its AI-driven shift toward automating customer data workflows. Under founders James Hawkins and his co-founder, the company abandoned traditional sales-led growth in favor of an open-source, product-first strategy that now serves 300,000 users with a suite of 17 products. This capital deployment enables PostHog to pursue an ambitious vision of an "automated product manager" while maintaining radical transparency and a polarizing brand identity built on building in public.

How Amplitude Went From Skeptics to “All In” on AI

Spenser Skates, Harj

Amplitude initiated a strategic pivot to AI-native development in late 2024 following the acquisition of Command AI and the hiring of Wade Chambers, aiming to replace traditional SaaS workflows with a "technology-first" product philosophy. The company has already launched AI feedback and visibility tools while preparing a global chat interface for January 2025 that Spencer Skates predicts will reinvent the analytics industry by becoming a "Cursor for Analytics." This transformation involved restructuring leadership to prioritize AI-native thinking and retaining key talent through a commitment to fund future ventures, positioning Amplitude to capitalize on legacy competitors' slowness in the emerging market.