Latest Interviews
Showing 121–135 of 150 transcripts.
Clear all filters- 80,000 Hours1h 44m
#37 - GiveWell picks top charities by estimating the unknowable. James Snowden on how they do it.
James Snowden, Keiran Harris, Rob Wiblin
Founded a decade ago by Holden Karnofsky and Ellie Hassenfeld, GiveWell directs approximately $100 million annually to nine evidence-backed charities in international development after applying rigorous cost-effectiveness and transparency criteria. The San Francisco-based organization recently expanded its portfolio to include five new top recommendations while navigating internal ethical debates over suicide prevention and evolving its analytical models to account for leverage and funding effects. With a team of over 20 employees focused on an "epistemic culture," the group continues to explore policy interventions and speculative research opportunities beyond traditional direct service models.
- 80,000 Hours2h 5m
#36 - Tanya Singh on ending the operations management bottleneck in effective altruism
Tanya Singh, Professor Bostrom, Tara Mac Aulay, Keiran Harris, Rob Wiblin
An episode featuring Tanya Singh from the Future of Humanity Institute and representatives from the Centre for Effective Altruism addresses the critical shortage of operational talent hindering the scaling of effective altruism organizations. The discussion defines operations as creative problem-solving roles that act as force multipliers for researchers, highlighting open positions at GiveWell, Open Philanthropy, and OORT that require high value alignment and adaptability. With applications for several key roles closing within days, the event outlines the specific skills, such as systems prototyping and automation, necessary for candidates to prevent organizational stagnation in a sector marked by significant growth potential.
- 80,000 Hours1h 23m
#35 - Tara Mac Aulay on the audacity to fix the world without asking permission
Tara Mac Aulay, Keiran Harris, Rob Wiblin
Former CEA CEO and Operations Specialist Tara McCauley leveraged a background in data-driven optimization across sectors like healthcare and humanitarian aid to transform organizational efficiency, notably saving millions at St. Vincent's Hospital and mitigating fatal systemic errors in Bhutan. She applies these lessons at the Centre for Effective Altruism by prioritizing "invisible" infrastructure and a culture where the best argument wins, while advocating for operations as a distinct, high-skill career path essential for scaling mission-critical work. Currently, McCauley is recruiting UK and US Operations Specialists, an Events Specialist, and a CEO Office Project Manager to further build the sector's operational capacity before the application deadline on July 6th.
- 80,000 Hours2h 19m
#34 - We use the worst voting system that exists. Here's how Aaron Hamlin is going to fix it.
Aaron Hamlin, Edwin Edwards, David Duke, Buddy Roemer, Keiran Harris, Rob Wiblin
The Center for Election Science leverages a $600,000 Open Philanthropy grant to advance voting reform by advocating for Approval Voting as a superior alternative to the flawed First-Past-The-Post system. By targeting municipal ballot initiatives in cities like Fargo and San Francisco, the organization aims to break the two-party duopoly and elect moderate consensus candidates without the complexities of Instant Runoff Voting. This grassroots strategy seeks to scale successful local implementations into state and federal adoption, ultimately reducing political polarization and increasing voter efficacy through a robust, transparent electoral mechanism.
- 80,000 Hours2h 26m
#32 - Bryan Caplan on whether his Case Against Education holds up, totalitarianism, & open borders
Bryan Caplan, Keiran Harris, Rob Wiblin
Econometrician Tyler Cowen's analysis of *The Case Against Education* argues that formal schooling primarily functions as a signaling mechanism for conformity rather than a generator of human capital, leading to a societal misallocation of resources toward credential inflation. This framework extends to global policy, where Cowen contends that open borders and deregulated housing offer superior welfare gains compared to current systems, while highlighting the existential risks of permanent totalitarianism if technological advancements eliminate competitive checks on power. Drawing from these premises, he advises individuals to prioritize vocational over academic pathways unless a degree is strictly necessary for entry, and suggests that effective altruism should focus on immigration reform and the release of non-violent offenders to maximize moral impact.
- 80,000 Hours48 min
#31 - Prof Dafoe on defusing the political & economic risks posed by existing AI capabilities
Prof Dafoe, Allan Dafoe, Keiran Harris, Rob Wiblin
The Future of Humanity Institute's AI Governance program unites a dozen researchers to analyze the technical, political, and institutional challenges posed by the transition to superhuman AI. Led by figures such as Alan Daffo, Demis Hassabis, and Vladimir Putin, the field addresses risks ranging from labor displacement and strategic instability to the potential for a dangerous "race to the finish" among nation-states. Despite the current fragmentation of the discipline, experts maintain a strategic focus on building global cooperation frameworks to harness advanced AI's vast potential while preventing catastrophic outcomes.
- 80,000 Hours2h 2m
#30 - Dr Eva Vivalt on how little social science findings generalize from one study to another
Dr Eva Vivalt, Keiran Harris, Rob Wiblin
Y Combinator launched a $100 million, three-to-five-year randomized controlled trial providing $1,000 monthly to approximately 1,000 low-income young adults to analyze shifts in time use, health, and well-being while deliberately withholding results until the study's conclusion to prevent narrative distortion. This initiative is situated within a broader academic discourse highlighting the limited generalizability of development interventions and the prevalence of optimism bias among policymakers, who often neglect variance and negative results in favor of optimistic point estimates. Experts argue that despite these methodological challenges and academic incentives prioritizing novelty over synthesis, aggregated expert priors and robust RCTs remain essential for refining evidence-based policy and overcoming the "naturalistic heuristic" in emerging fields like clean meat adoption.
- 80,000 Hours1h 3m
#28 - Dr Cotton-Barratt on why scientists should need insurance, PhD strategy & fast AI progresses
Dr Cotton-Barratt, Dr Owen Cotton-Barratt, Keiran Harris, Rob Wiblin
Owen Cotton Barrett advocates for early-career researchers to prioritize high-impact problems over academic prestige and proposes internalizing scientific liability through insurance mechanisms to address catastrophic risks like pandemics. He further outlines a diversified AI safety strategy that balances immediate action with long-term infrastructure building, noting that the Future of Humanity Institute is launching a new program to support pre-paradigmatic research without requiring a PhD. The discussion also highlights upcoming EA Global events in San Francisco, London, and other locations as key opportunities for community engagement in these fields.
- 80,000 Hours2h 17m
#27 - Dr Tom Inglesby on careers and policies that reduce global catastrophic biological risks
Dr. Thomas Inglesby and the Center for Health Security outline a strategic shift from natural pandemic preparedness to addressing global catastrophic biological risks as biotechnology becomes increasingly accessible. To mitigate these threats, the organization advocates for a unified U.S. biodefense strategy and the creation of a dedicated public health emergency fund to overcome historical funding delays. Concurrently, the Center's Emerging Leaders Fellowship and partnerships with the Open Philanthropy Project aim to cultivate a multidisciplinary workforce capable of integrating deep scientific expertise with policy implementation.
- 80,000 Hours1h 45m
#26 - Marie Gibbons on how exactly clean meat is made & whats needed to get it in every supermarket
Marie Gibbons, Natalie Cargill, Keiran Harris, Rob Wiblin
Marie Gibbons predicts that cell-based meat will reach the consumer market by year-end at a premium price, with production costs expected to achieve parity with conventional meat within a decade through improved bioreactor scaling and media optimization. The technology relies on harvesting satellite cells via humane biopsy and utilizing plant-based scaffolds to create initial burger formats, while future whole-cut developments depend on overcoming growth factor dependencies through recombinant proteins or genetic editing. Gibbons emphasizes that accelerating this transition requires coordinated industry efforts across major research hubs in Boston and London to prioritize species-specific biological protocols and reduce animal suffering more effectively than advocacy alone.
- 80,000 Hours2h 40m
#25 - Prof Robin Hanson on why we have to lie to ourselves about why we do what we do
Robin Hanson, Kevin Simler, Keiran Harris, Rob Wiblin
Robin Hanson and Kevin Simler propose in *The Elephant in the Brain* that human institutions like education, medicine, and charity function primarily as signals of status and virtue rather than fulfilling their stated goals. By exposing how self-deception and hidden motives sustain these systems, the authors argue that effective reform requires designing policies that allow individuals to maintain their high-minded self-image while actually achieving better real-world outcomes. This perspective challenges conventional wisdom across sociology and futurology, urging a shift from abstract idealism to pragmatic strategies aligned with true human incentives.
- 80,000 Hours55 min
#24 - Stefan Schubert on why it’s a bad idea to break the rules, even if it’s for a good cause
Stefan Schubert, Keiran Harris, Rob Wiblin
Stefan Schubert examines the tension between epistemic modesty and effective altruism's cultural cohesion, warning that overconfidence and political tribalism threaten the movement's rational foundations while urging a shift toward specialized expertise. He analyzes organizational trends where talent gaps now overshadow funding constraints and highlights the slow pace of "creative destruction," noting that the community's reputation for integrity remains a fragile asset that demands strict adherence to norms over short-term gains. Ultimately, Schubert clarifies the concept of cause neutrality to argue that deep confidence in existential risks like AI safety can coexist with a willingness to update beliefs, provided the movement avoids irreversible political entanglements and continues expanding its reach into the developing world.
- 80,000 Hours1h 8m
#22 - Dr Leah Utyasheva on the non-profit that figured out how to massively cut suicide rates
Dr Leah Utyasheva, Keiran Harris, Rob Wiblin
Founded in 2016 by Leah Utyasheva and Professor Michael Eddleston, the Centre for Pesticide Suicide Prevention advocates for banning highly toxic Class 1A pesticides to address the 150,000 annual deaths caused by impulsive agricultural self-poisoning. Backed by a GiveWell grant and affiliated with the University of Edinburgh, the organization is collecting hospital data from India and Nepal to demonstrate that restricting access to these lethal means is a cost-effective strategy, having already saved 93,000 lives in Sri Lanka. This evidence-based approach aims to persuade local regulators to prioritize means reduction over ineffective safe storage measures, thereby relieving overwhelmed health systems and fulfilling government obligations to protect citizen safety.
- 80,000 Hours2h 36m
#21 - Holden Karnofsky on times philanthropy transformed the world & Open Phil’s plan to do the same
Holden Karnofsky, Margaret Sanger, Gregory Pincus, Katherine McCormick, Keiran Harris, Rob Wiblin
The Open Philanthropy Project, funded primarily by Good Ventures, operates on a venture-capital model to deploy over $100 million annually toward high-risk, high-impact causes including U.S. criminal justice reform, farm animal welfare, and artificial intelligence safety. The organization employs a distinct "50-40-10" grant approval framework and prioritizes field building to create expert communities in neglected areas like AI alignment and pandemic preparedness. Through strategic board engagement at institutions like OpenAI and a rigorous, truth-seeking hiring culture, the project aims to mitigate global catastrophic risks while maximizing philanthropic returns on long-term societal transformation.
- 80,000 Hours1h 18m
#20 - Bruce Friedrich on inventing outstanding meat substitutes to end speciesism & factory farming
Bruce Friedrich, Natalie Cargill, Keiran Harris, Rob Wiblin
The Good Food Institute executes a strategy to displace industrial animal agriculture by accelerating the development of plant-based and clean meats that compete on price, taste, and convenience rather than ethical appeal. While current market share for alternatives remains below 1% amidst a record 9 billion annual animal slaughters, industry experts project cost parity with conventional meat within a decade through bioreactor scaling and synthetic biology. Operating as a rapidly expanding nonprofit funded entirely by philanthropy, the organization targets a 2050 vision where these technologies collectively fulfill 100% of global meat demand.