Patrick Tan

The Asian Phenotype: An Unmet Medical Need?

Benjamin Seet, John Connolly, Laurent Metz, Arthur Mark Richards, Patrick Tan

Experts highlight that distinct genetic, environmental, and anatomical factors create a unique Asian phenotype, driving divergent disease patterns such as higher cardiovascular risks at lower BMI thresholds and specific cancer profiles like biliary tract malignancies. These biological differences have spurred regulatory shifts in Asia toward homegrown standards for advanced therapies while prompting medical device and pharmaceutical companies to develop localized solutions, including smaller implants and tailored dosing regimens. The ongoing transition to personalized medicine relies on integrating granular real-world data and cultural context to address these population-specific needs effectively.