Drug-Drug Interaction Study of Pacritinib and CYP450,Transporter Substrates, and CYP450 3A4 in Healthy Male Subjects - NCT05657613

To assess the effect of pacritinib on the systemic exposure of digoxin, midazolam omeprazole, rosuvastatin, caffeine and metformin, To assess the effect of pacritinib on the systemic exposure of digoxin, midazolam, omeprazole, rosuvastatin, caffeine, and metformin, To assess the effect of bosentan (CYP450 3A4 inducer) on the systemic exposure of multiple doses of pacritinib, (and 5 more...)