ClinicalTrials.gov
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- 1d agoObservation and Interactions Between Cardio-respiratory and Motor Transitions During Maximal Incremental Exercise Test on Elliptical Bike and Running Treadmill. - NCT07928713ClinicalTrials.govFor safety considerations and to ensure the effectiveness of physical activity within a rehabilitation programme, it is important to establish an appropriate exercise intensity to achieve the programme's objectives. This requires identifying individualised exercise intensity zones that are specifically tailored to each patient, in order to design an effective and progressive exercise training prog ...
- 1d agoA Multi Center Evaluation of TearCare on Surgical Measurements Before Cataract Surgery - NCT07928986ClinicalTrials.govThe goal of this study is to evaluate whether TearCare treatment stabilizes corneal measurements sufficiently to determine when cataract biometry can be considered reliable.
- 1d agoImplementation, Safety, and Effectiveness of Outpatient Cardiac Telerehabilitation in Patients With Ischemic Heart Disease - NCT07927829ClinicalTrials.govThe goal of this prospective interventional study is to evaluate the effectiveness and safety of an outpatient cardiac telerehabilitation program during phase II rehabilitation in patients with ischemic heart disease. The main question is whether an outpatient cardiac telerehabilitation program during phase II rehabilitation is effective and safe for patients with ischemic heart disease. Research ...
- 1d agoClinical Characteristics, Treatment, Diagnostic Findings, and Outcomes of Tuberculous Meningitis in Indonesia, 2022-2025 - NCT07929519ClinicalTrials.govTBM Study is a multicenter, observational, retrospective cohort study of Tuberculous Meningitis (TBM) patients who underwent treatment at the hospital during the 2022-2025 period. The goal of this study is to learn about the clinical characteristics, diagnostic findings, drug resistance profiles, treatment regimens, complications, and treatment outcomes of patients diagnosed with TBM who were admi ...
- 1d agoClinical Pharmacist-Led Cardiovascular Risk Assessment in Patients With Chronic Kidney Disease (CRICKD) - NCT07927959ClinicalTrials.govChronic kidney disease (CKD) is a long-term condition that can increase the risk of cardiovascular diseases, such as heart attacks and strokes. People with CKD often have other health conditions and take several medications, which can make following treatment plans challenging. Clinical pharmacists may help these patients by reviewing their medications, providing education, and supporting medicati ...
- 1d agoEffects of Diaphragmatic Kinesio Taping Combined With Pulmonary Rehabilitation on Diaphragm Muscle Thickness in Intensive Care Patients - NCT07929038ClinicalTrials.govThis prospective, three-arm, randomized controlled trial aims to investigate the effects of diaphragmatic Kinesio taping applied in addition to pulmonary rehabilitation on diaphragm muscle thickness and function in intensive care unit (ICU) patients. A total of 48 patients admitted to the ICU due to respiratory distress will be recruited and randomly assigned to three groups: pulmonary rehabilita ...
- 1d agoNurse-Led Interventions Addressing Physical Exercise and Psychological Needs on Enhancing Outcomes in Patients With Chronic Renal Failure - NCT07927660ClinicalTrials.govThis study aimed to evaluate the effect of a nurse-led intervention addressing physical exercise and psychological needs on enhancing outcomes among patients with chronic renal failure.
- 1d agoEfficacy and Safety of Polisorb® MP in the Complex Therapy of Patients With Atopic Dermatitis - NCT07929181ClinicalTrials.govThis multicenter, open-label, randomized Phase III clinical trial evaluated the efficacy and safety of adding Polisorb® MP, an oral colloidal silicon dioxide adsorbent, to basic therapy in adults with mild to moderate atopic dermatitis. The study included 161 patients in the efficacy analysis. Participants were randomly assigned to receive either basic therapy alone (81 patients) or basic therapy ...
- 1d ago[Trial of device that is not approved or cleared by the U.S. FDA] - NCT07930052ClinicalTrials.gov
- 1d agoEFFECTIVENESS OF A SCHOOL-CENTRED PRIMARY AND SECONDARY PREVENTION PROGRAM ON PREVALENCE OF LATENT RHEUMATIC HEART DISEASE - NCT07927868ClinicalTrials.govThis study consists in an RHD awareness campaign and a school nurse program providing integrated health care through assessment, intervention, and follow-up of GABHS pharyngitis, and facilitation of secondary antibiotic prophylaxis for children with latent RHD.
- 1d agoPNF Plus Progressive Rehabilitation for Adolescent Athletes With Osgood-Schlatter Syndrome - NCT07928778ClinicalTrials.govOsgood-Schlatter syndrome is a common cause of knee pain in adolescent athletes. It occurs during periods of growth and is often associated with sports activities involving running, jumping, and repeated knee movements. Pain may limit participation in sports and other physical activities. This study aims to investigate whether combining proprioceptive neuromuscular facilitation (PNF) relaxation t ...
- 1d agoAssessing the Effect of Infant-directed Unidirectional Feeding Valves on Milk Volume Intake in Infants With Cleft Palate - NCT07927933ClinicalTrials.govThis study aims to assess the impact of using a cleft-adapted bottle with a unidirectional valve compared with a non-cleft-adapted bottle on oral volume intake and milk transfer rate.
- 1d agoA Study of Retifanlimab After Chemoradiation in People With Anal Cancer - NCT07927998ClinicalTrials.govParticipants will receive retifanlimab during 28-day treatment Cycles and will continue to receive retifanlimab for up to 6 Cycles (up to 12 Cycles with study doctor approval) unless the participant's cancer comes back, have serious side effects and cannot continue study treatment, or the study doctor thinks it is in the participant's best interest to stop.
- 1d agoIntra-articular Vitamin D3 Injection for Patients With Temporomandibular Joint Osteoarthritis - NCT07929103ClinicalTrials.govThe goal of this clinical trial is to evaluate the efficacy of intra-articular Vitamin D3 injection for the treatment of temporomandibular joint (TMJ) osteoarthritis. The main questions it aims to answer are: is intra-articular Vitamin D3 injection more effective than placebo in the treatment of temporomandibular joint osteoarthritis? . Does it improve secondary clinical outcomes such as pain-free ...
- 1d agoDifferential Granulosa Cell Transcriptome Profiling as a Predictive Tool of Ongoing Pregnancy - NCT07929779ClinicalTrials.govFertility problems are increasingly common in industrialized countries. It is estimated that 15-20% of couples of reproductive age have problems conceiving children naturally and the use of assisted reproductive treatment accounts for 1-3% of annual births. Among the causes of infertility, the female factor is responsible for approximately 40% of cases. The growing problem of infertility and the d ...
- 1d agoEvaluation of an Early Preventive and Educational Care Pathway for Moderate and Late Preterm Infants. A Randomized Controlled Study - NCT07928830ClinicalTrials.govPrematurity is associated with a high risk of neurodevelopmental disorders (NDDs). The prognosis for moderate and late preterm infants (32 to \<37 weeks of gestational age) is better than that for very preterm infants (\<32 weeks of gestational age). According to the French National Authority for Health (Haute Autorité de Santé, HAS), moderate and late preterm (MLPT) infants are at moderate risk ...
- 1d agoSCREEN Yourself for Cancer - NCT07927686ClinicalTrials.govThis randomized controlled trial will evaluate whether evidence-based self-sampling tools improve the cancer screening process among underscreened patients. Participants who are eligible but out-of-date for colorectal cancer screening, cervical cancer screening, or both will be randomized to either usual practice or an intervention that includes mailed self-sampling tools for the appropriate cance ...
- 1d agoAnalysis of the Positivity Rate of Sector-based Whole-body CT Scans in Grade C Trauma Patients in Essonne - NCT07929168ClinicalTrials.govBackground: Grade C trauma patients show no obvious severe injury at first assessment, but the mechanism or circumstances of the accident make serious lesions possible. Guidelines recommend a whole-body CT scan as first-line imaging1. The organization of the French trauma system varies between regions2. Île-de-France distinguishes level 1 trauma centers, which are authorized to manage the most sev ...
- 1d agoImpact of Oral vs. Transdermal Oestrogen on Cortisol & CBG Before SST - NCT07928024ClinicalTrials.govCortisol is a hormone that helps the body handle stress and maintain blood pressure. Doctors check if the adrenal glands (which make cortisol) are working correctly using a Synacthen test (SST). This test involves giving a drug that stimulates cortisol production and measuring how much is released. For women taking oestrogen pills (found in birth control and hormone replacement therapy), the test ...
- 1d agoSocial Media Perceptions Among Young Adults With Cancer - Online Experiment 2 - NCT07928349ClinicalTrials.govYoung adults with cancer experience more loneliness than their non-cancer peers or older cancer survivors. Positive psychology interventions have promise to increase social connectedness; however, evidence-based interventions should be tailored for young adults with cancer and designed for social media. The investigators conducted an online experiment with young adults with cancer (ages 22-39) to ...
- 1d agoNeoadjuvant Finotonlimab Plus TP Regimen in Locally Advanced INI-1-Deficient Sinonasal Carcinoma - NCT07927465ClinicalTrials.govThis is a prospective, multicenter, single-arm phase 2 study in adults with locally advanced (T3/T4) INI-1 (SMARCB1)-deficient sinonasal carcinoma, a very rare and aggressive cancer of the nasal cavity and sinuses. This cancer often invades the skull base, eyes, nerves, and surrounding critical structures, making surgery difficult and potentially disabling. Current standard treatment is usually su ...
- 1d agoFulvic Acid Supplementation and Metabolic Syndrome - NCT07927283ClinicalTrials.govFulvic acid is a naturally occurring compound derived from the decomposition of organic matter in soil over long periods. Fulvic acid complexes, such as MLG-50 (MLG-50® Mineral Logic, Kalamazoo, Michigan), offer a highly concentrated, water-soluble form of fulvic acid that contains over 70 trace minerals and elements. Our preclinical studies have found that a soil derived organic mineral complex r ...
- 1d agoCD19 Sequential CD22 In Vivo CAR-T Cell Immunotherapy for Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia - NCT07927816ClinicalTrials.govThis is a single-center, open-label, single-arm, prospective, investigator-initiated dose-escalation study to evaluate the safety, tolerability, preliminary efficacy, and cellular kinetics of an in vivo CAR-T cell immunotherapy targeting CD19 sequentially followed by CD22, in patients with relapsed or refractory B-cell acute lymphoblastic leukemia (R/R B-ALL). The investigational product is a targ ...
- 1d agoFosfomycin Trometamol Compared With an Alternative Active Antibiotic as Step-down Therapy for the Treatment of Acute Pyelonephritis Due to Escherichia Coli in Elderly Women : a Randomized, Multicenter, Non-inferiority Trial - NCT07928063ClinicalTrials.govAcute pyelonephritis (APN) is among the most common bacterial infections in older women. Oral step-down antibiotic therapy may potentially be associated with toxicity, particularly with fluoroquinolones or trimethoprim-sulfamethoxazole, espcially in geriatric patients. The emergence of resistant strains reduces the choice of oral step-down treatment, thereby increasing the risk of nosocomial compl ...
- 1d agoEffectiveness and Safety of Cellbooster Glow in Healthy Subjects - NCT07929870ClinicalTrials.govThe current post-market clinical investigation is designed to evaluate the efficacy and safety of Cellbooster Glow (CBG). For this purpose, healthy participants with signs of skin aging in the face will receive a 3-session treatment and will be followed-up over 70 days after the initial injection session. Several objective measurements of skin quality will be performed with different instruments a ...
- 1d agoPulsed Field Ablation for Atrial Fibrillation Under General Anesthesia Versus Remimazolam-based Deep Sedation - NCT07927582ClinicalTrials.govReal-world evidence indicates that deep sedation is the predominant anesthesia strategy for pulsed field ablation (PFA) in most European centers, whereas general anesthesia remains the standard of care in China. Given disparities in anesthesiologist availability and fundamental differences in healthcare system infrastructure and workflow organization, establishing an electrophysiologist-led deep s ...
- 1d agoOral B-Complex Vitamin (B6, B9 and B12) Prevents Low Anterior Resection Syndrome in Rectal Cancer Patients With Hyperhomocysteinemia - NCT07928180ClinicalTrials.govThe goal of this clinical trial is to investigate if taking Oral B-Complex Vitamin (B6, B9 and B12) can help prevent low anterior resection syndrome (LARS) in rectal cancer patients with hyperhomocysteinemia after sphincter-preserving surgery for rectal cancer. LARS is a group of bowel problems that can occur after rectal cancer surgery, including frequent bowel movements, an urgent need to have a ...
- 1d agoSurgical Window Study of CM93 in Subjects With Recurrent Glioblastoma (rGBM) - NCT07927491ClinicalTrials.govThis is an open-label, first-in-human phase 1 and surgical window of opportunity study designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and preliminary anti-tumor activity of CM93 in subjects with recurrent glioblastoma (rGBM) characterized by Epidermal Growth Factor Receptor (EGFR) amplification/mutation who have previously received at least 1st-line high-grade gl ...
- 1d agoHigher-Dose Maintenance With ERZOFRI 351 mg in Adults With Schizophrenia - NCT07927946ClinicalTrials.govThis is a prospective, multicenter, open-label, single-arm study evaluating ERZOFRI (paliperidone palmitate) 351 mg administered every 4 weeks as maintenance treatment in approximately 40 adults with schizophrenia who experience symptom worsening before their next scheduled monthly injection despite receiving paliperidone palmitate 234 mg every 4 weeks. Participants will receive ERZOFRI 351 mg on ...
- 1d agoDESAL-HEART: Hypertonic Saline Added to a Pre-declared Furosemide Dose in Acute Heart Failure - NCT07927127ClinicalTrials.govDESAL-HEART is a multicenter, randomized, open-label, blinded-endpoint, mechanistic proof-of-concept trial conducted within the Heart Failure Efficacy and Research Trial (HEART) Platform. The study will evaluate whether adding a single infusion of 3% hypertonic saline solution (HSS) to a pre-declared intravenous furosemide dose improves decongestion in patients hospitalized with acute heart failur ...
- 1d agoImplementation Research Zero-dose and Under-immunized Children - NCT07928115ClinicalTrials.govBackground: This protocol describes both a broader development initiative to address the needs of "zero-dose" (ZD) and under-vaccinated children, and embedded research. The embedded research includes primary data collection through interview and group discussions, and formal implementation research activities. All are funded by Gavi, the vaccine Alliance to generate timely information products fo ...
- 1d agoSimulation-Based Versus Traditional Training for Percutaneous Endoscopic Gastrostomy Care in Nursing Students - NCT07929389ClinicalTrials.govThis randomized controlled trial aimed to compare the effects of simulation-based training and traditional demonstration-based training on knowledge and practical skills related to percutaneous endoscopic gastrostomy (PEG) care among first-year nursing students. The study included 40 nursing students who were randomly assigned to two groups: a simulation-based training group (n=20) and a traditio ...
- 1d agoSymptomatic FIT for Colon Cancer Detection, a Pilot Study - NCT07927270ClinicalTrials.govThis pilot study will assess whether a larger study of stool testing for colorectal cancer is practical. It plans to enroll 40 adults born in 1960 or later who have new symptoms that could be related to colorectal cancer. Participants will collect a stool sample at home using a fecal immunochemical test (FIT), complete a questionnaire, and undergo blood tests and colonoscopy as part of their usual ...
- 1d agoSpatiotemporal Modeling of Tuberculosis Transmission Risk in a Clinical Waiting Room Using Environmental and Patient Movement Data: Impact of Simple Patient Management Interventions - NCT07927881ClinicalTrials.govTo establish a novel approach for estimating the risk of TB transmission in a healthcare clinic in a high TB/HIV setting in Zambia using data on patient characteristics, indoor CO2 and bioaerosol measurements, and patient flows from video sensors.
- 1d agoEffect of Head and Neck Positioning on Awake Fiberoptic Intubation in Obese Patients - NCT07928843ClinicalTrials.govThe aim of the study was the assessment and comparison of the time taken for vocal cord visualization with three different head positions: (conventional sniffing position, ramp position and supine position) in obese patients
- 1d agoRehaBEElitation - Serious Game-Based Experimental Protocol to Improve Manual Dexterity in Individuals With Parkinson's Disease - NCT07928050ClinicalTrials.govThis is a non-randomized controlled trial with two parallel groups, with the general objective of developing and applying an assessment and intervention protocol based on a serious game for the rehabilitation of hand function in individuals with Parkinson's disease (PD). The experimental group trained with the RehaBEElitation serious game, controlled by hand and wrist movements through a wearable ...
- 1d agoLactium Versus Midazolam Premedication on Postoperative Negative Behavioral Changes - NCT07928947ClinicalTrials.govThis prospective randomized double-blind placebo-controlled study will be conducted to compare the effects of preoperative oral lactium and midazolam on the incidence of postoperative negative behavioral changes in young children undergoing adenotonsillectomy.
- 1d agoFunctional, Cognitive, and Behavioral Correlates of Resistance Training During Tirzepatide-Induced Weight Loss - NCT07929571ClinicalTrials.govThis study is an ancillary study to the RESIST trial, in which adults with obesity receive the weight-loss medication tirzepatide and are randomly assigned to a structured resistance training program or to usual care for 24 weeks. RESIST-MIND explores whether resistance training during tirzepatide treatment is associated with changes in attention and concentration, food-related thoughts ("food no ...
- 1d agoVirtual Reality vs. Gym-Based Martial Arts Training for Aggression in Children With Conduct Disorder - NCT07929025ClinicalTrials.govThe goal of this clinical trial is to learn if martial arts training helps lower aggression in children with conduct disorder. It will also compare two ways of delivering this training: through virtual reality (VR) headsets and in a traditional gym. The main questions it aims to answer are: Does martial arts training lower overall aggression in children with conduct disorder? Do the effects last ...
- 1d agoINPACT: Implementation of Nutritional Support and Physical Activity During Cancer Treatment - NCT07929597ClinicalTrials.govThe INPACT study investigates whether a structured program combining physical exercise, nutritional support, and breathing exercises can improve physical fitness and recovery in patients undergoing liver surgery for cancer. Approximately 103 adult patients with primary liver cancer or liver metastases who are scheduled for liver resection will participate. Participants will be randomly assigned t ...
- 1d agoProject Raising Exposure Awareness for Caregiver Help-Seeking - NCT07929077ClinicalTrials.govThe goal of this pilot randomized study is to learn whether a dissemination campaign co-designed with a community advisory board helps caregivers of children with anxiety and related disorders seek exposure therapy, compared with standard information. Participants are caregivers of children ages 4 to 18 with current anxiety, OCD, or traumatic stress symptoms. The main questions it aims to answer ...
- 1d agoEvaluation of the EPDS and PC-PTSD-5 Scales for Screening Postpartum Mental Health Disorders Among Migrant Women. - NCT07929272ClinicalTrials.govPostpartum depression (affecting approximately 15% of women) and childbirth-related post-traumatic stress disorder (PTSD) (affecting approximately 5%) are major public health concerns due to their frequency and their impact on both maternal and child health. Diagnosis relies on specialized clinical interviews, which are difficult to offer systematically to all women after childbirth. Consequently, ...
- 1d agoBCMA/GPRC5D Dual-Target CAR-T Cell Immunotherapy for Relapsed/Refractory Multiple Myeloma - NCT07927842ClinicalTrials.govThis is a single-center, open-label, single-arm, investigator-initiated clinical study to evaluate the safety, tolerability, and preliminary efficacy of SL4903, a BCMA/GPRC5D dual-target autologous CAR-T cell injection, in patients with relapsed or refractory multiple myeloma (R/R MM) whose clonal plasma cells are positive for BCMA and/or GPRC5D. After leukapheresis, participants receive lymphodep ...
- 1d agoA Phase 1/2a Clinical Study of KL002 in Treatment of Parkinson's Disease - NCT07929480ClinicalTrials.govTo assess the safety and tolerability of single doses of KL002 over 78 weeks in subjects with Parkinson's disease。
- 1d agoSalicylic Acid Solution Versus Tretinoin 0.05% Cream for Treating Plane Warts - NCT07927920ClinicalTrials.govThis randomized controlled trial aims to compare the effectiveness and safety of topical salicylic acid solution (15-17%) and tretinoin 0.05% cream in treating plane warts. A total of 200 patients aged 12-40 years will be recruited from the Dermatology Department of Combined Military Hospital (CMH), Abbottabad, and randomly divided into two treatment groups. Both treatments will be applied once da ...
- 1d agoACEs, CBT-i, and Cardiovascular Health - NCT07927335ClinicalTrials.govOur accumulating evidence indicates that young adults that have been exposed to Adverse Childhood Experiences (ACEs) display both impaired vascular function, poorer cardiometabolic health, and poor sleep. Our data indicate that sleep impairments may mediate the link between ACEs and vascular and metabolic dysfunction. The primary purpose of this project is to determine if cognitive behavioral ther ...
- 1d agoThe Effect of Simulation-Based Training on the a Care Bundle to VIP - NCT07927855ClinicalTrials.govVentilator-associated pneumonia (VAP) is one of the most serious and frequent healthcare-associated infections occurring in premature and low-birth-weight infants in neonatal intensive care units. The literature on VAP prevention strongly indicates that a "care bundle" approach is among the most effective methods for reducing the incidence of this infection. The objective of this research is to d ...
- 1d agoEffects of TENS With and Without Core Stabilization Exercises on Low Back Pain, Inter-Recti Distance, and Transversus Abdominis Thickness in Postpartum Women With Diastasis Recti Abdominis - NCT07929727ClinicalTrials.govLow back pain is a common complaint among postpartum females, often associated with diastasis recti abdominis (DRA), a condition characterized by the separation of the rectus abdominis muscles. This separation can lead to reduced core stability, altered biomechanics, and impaired functional performance. Effective rehabilitation strategies are essential to address pain, restore abdominal muscle int ...
- 1d agoHistoMap AlloSure Renal Biopsies Observational Research Study - NCT07927374ClinicalTrials.govThe HistoMap AlloSure Renal Biopsies Observational Research Study (HARBOR) is a prospective, multicenter, observational cohort study of adult kidney transplant recipients undergoing a clinically indicated kidney allograft biopsy. The study will collect biospecimens and associated clinical data to support the development and evaluation of molecular approaches for assessing kidney allograft rejectio ...
- 1d agoRhomboid Intercostal Block Versus Retrolaminar Plane Block for Postoperative Analgesia in Patients Undergoing Video Assisted Thoracic Surgery. - NCT07928544ClinicalTrials.govRetrolaminar block (RLB)(a modified form of paravertebral block (PVB) and The ultrasound-guided rhomboid intercostal block (UG-RIB) used to alleviate the postoperative pain in video assisted thoracic surgery (VATS). We hypothesized that RLB may offer superior analgesic coverage and efficacy compared to The ultrasound-guided rhomboid intercostal block (UG-RIB) in the context of VATS. 1\. INTRODUCT ...