New patent application published for: USE OF PHARMACEUTICAL COMPOSITION IN THE PREPARATION OF DRUG FOR ENHANCING ANALGESIC EFFECT

USE OF PHARMACEUTICAL COMPOSITION IN THE PREPARATION OF DRUG FOR ENHANCING ANALGESIC EFFECT

Claims

1. A method of analgesia, comprising administering to a subject a therapeutically effective amount of a pharmaceutical composition, wherein the pharmaceutical composition comprises an analgesic drug and a terpene drug; the analgesic drug comprises at least one of a local anesthetic and a nonsteroidal anti-inflammatory drug; and the terpene drug comprises at least one of menthol, camphor, linalool, and eucalyptol.
2. The method of claim 1, wherein the local anesthetic comprises at least one of bupivacaine and ropivacaine.
3. The method of claim 1, wherein the nonsteroidal anti-inflammatory drug comprises at least one of meloxicam and celecoxib.
4. The method of claim 1, wherein the pharmaceutical composition further comprises at least one of a delivery carrier and a solvent.
5. The method of claim 4, wherein the solvent comprises at least one of alcohols, dimethyl sulfoxide, ethyl lactate, glycerol formal, N-methylpyrrolidone, glycerol triacetate, benzyl benzoate, dichloromethane, water, and glycerol trioctanoate.
6. The method of claim 4, wherein the delivery carrier comprises at least one of a saccharide and an esterified form thereof, a phospholipid, a polyester, and an oil.
7. The method of claim 6, wherein the saccharide and an esterified form thereof comprise at least one of sucrose, chitosan, sucrose acetate isobutyrate, sucrose octaacetate, and sucrose monoacetate monoisobutyrate.
8. The method of claim 6, wherein the phospholipid comprises at least one of a natural phospholipid and a synthetic phospholipid.
9. The method of claim 8, wherein the natural phospholipid comprises at least one of soybean phosphatidylcholine, egg yolk phospholipid, rapeseed phospholipid, and sunflower phospholipid.
10. The method of claim 8, wherein the synthetic phospholipid comprises at least one of dierucoyl phosphatidylcholine, dioleoyl phosphatidylcholine, palmitoyl oleoyl phosphatidylcholine, distearoyl phosphatidylcholine, dipalmitoyl phosphatidylglycerol, and distearoyl phosphatidylglycerol.
11. The method of claim 6, wherein the oil comprises at least one of castor oil, soybean oil, olive oil, palm oil, and sesame oil.
12. The method of claim 6, wherein the polyester comprises at least one of polylactic acid, poly(lactic-co-glycolic acid), polyglycolic acid, polydioxanone, polycaprolactone, poly(L-lactide-co-caprolactone), and poly(orthoester).
13. The method of claim 12, wherein the poly(orthoester) is selected from a non-thermoplastic poly(orthoester) having the following structure: ##STR00005## wherein R* is selected from any one of methyl, ethyl, propyl, or butyl; n is an integer from 5 to 400; and A is selected from any one of R.sup.1 or R.sup.3; R.sup.1 is ##STR00006##  R.sup.5 is selected from any one of H or C.sub.1-4 alkyl; R.sup.6 is ##STR00007##  is an integer from 0 to 10; and p and q are each independently selected from an integer from 1 to 20; R.sup.3 is ##STR00008##  and x is an integer from 1 to 5.
14. The method of claim 4, wherein the pharmaceutical composition further comprises a delivery carrier and a solvent; and in parts by weight, the pharmaceutical composition comprises 0.01-22 parts of an analgesic drug, greater than or equal to 0.01 parts and less than 5 parts of a terpene drug, 1-95 parts of a solvent, and 0.5-65 parts of a delivery carrier.
15. The method of claim 14, wherein a mass ratio of the local anesthetic to the terpene drug is 1 to 50:1.
16. The method of claim 1, wherein a formulation form of the pharmaceutical composition comprises any one of gel formulation or liposome.
17. The method of claim 1, wherein the pharmaceutical composition is prepared by comprising the step of: mixing raw material components to obtain the pharmaceutical composition.