Latest Interviews
Showing 331–345 of 892 transcripts.
Clear all filters- Milken Institute23 min
Time to Act: A Conversation with Noa Tishby | Global Conference 2025
New York Times bestselling authors Noah Tishby and Noah Argamani frame the May 2025 campus encampments as the culmination of a thirty-year ideological war driven by the American Muslim and Palestinian organization to delegitimize Israel through tactics resembling the anti-apartheid movement. Tishby characterizes the core conflict as a clash between Western liberal values and a jihadist ideology, arguing that anti-Zionism functions as a shape-shifting conspiracy theory indistinguishable from anti-Semitism. Despite widespread public opposition to the encampments, the speakers assert that normalizing such anti-democratic sentiment at the local level aims to eventually force a shift in federal policy, while urging allies to educate communities on the October 7th atrocities to counter this narrative.
- a16z38 min
Marc Andreessen Reveals His Biggest Wins and Mistakes at a16z
Marc Andreessen, Erik Torenberg
Founded in 2009 amidst the 2008 financial crisis, the firm initially raised a $300 million generalist fund before evolving by 2017 into a fully verticalized investment structure to address the need for deep domain expertise in complex "full-stack" companies. Operating with a US-centric footprint, the organization champions the "Little Tech" agenda to secure clear regulatory guidelines for startups and actively recruits global talent displaced by restrictive European policies. While navigating shifts in government relations and national security engagements, the firm maintains that successful world-beater trajectories depend heavily on specific micro-level decisions regarding timing and early market acquisitions.
- a16z38 min
Where Crypto Meets AI with Chris Dixon & David George
A recent analysis details the maturation of crypto infrastructure alongside the rapid commoditization of generative AI, highlighting how programmable money now facilitates real-world enterprise payments while AI models disrupt cognitive labor and traditional search revenue models. The discussion identifies a strategic convergence where cryptocurrency addresses value distribution challenges created by artificial intelligence, predicting that economic gains will concentrate at the extremes of semiconductor manufacturing and end-user applications. This synthesis of market dynamics informs an investment philosophy that prioritizes backing founders with deep, cross-disciplinary "earned secrets" rather than chasing speculative categories or second-place contenders.
- Milken Institute42 min
The American Athlete: Feeding the US Olympic Pipeline | Global Conference 2025
Pete Stavros, Maya Andrews, Dan Gable, Karch Kiraly, Carl Lewis
Former Olympic legends Maya Andrews, Dan Gable, Karch Kiraly, and Carl Lewis convened to address the critical financial instability threatening U.S. collegiate Olympic sports and the resulting vulnerability of the national team ahead of the 2028 Los Angeles Games. The panelists diagnosed a crisis where rising costs and revenue concentration have decimated programs in wrestling and volleyball, then proposed strategic remedies ranging from philanthropic reinvestment and antitrust lobbying to tuition reform and enhanced financial transparency. Beyond structural solutions, the discussion highlighted philosophical imperatives regarding the mastery of failure and disciplined routines, arguing that preserving the current NCAA-subsidized pipeline is essential for sustaining American athletic dominance and societal leadership.
- Y Combinator31 min
State-Of-The-Art Prompting For AI Agents
Industry leaders are advancing LLM agents beyond 1995-era prompting by establishing layered architectures that separate system logic from customer-specific context, utilizing meta-prompting techniques to dynamically refine instructions. Founders are simultaneously securing competitive moats by physically embedding with domain experts to generate high-quality evaluation datasets that translate deep operational knowledge into proprietary assets. This "forward-deployed" model, combined with specialized debug tools and distinct model behavioral archetypes, enables rapid scaling of seven-figure enterprise deals through continuous, data-driven prompt optimization.
- Goldman Sachs30 min
Alnylam’s Yvonne Greenstreet on RNAi and a ‘golden era’ in biotech
Alnylam Pharmaceuticals leverages a decade of RNA interference research to achieve a 55% clinical success rate and recently secured approval for Amvutra to treat hereditary transthyretin-mediated amyloidosis. Under CEO Yvonne Greenstreet, the company aims to become a top-five biotech leader by 2026 through a five-year strategy to deliver 25 clinical programs and expand into common diseases like hypertension. To reach this goal, Alnylam integrates AI-driven drug design with a culture of diversity and patient advocacy to de-risk development and target tissues beyond the liver, including the central nervous system.
- All-In Podcast25 min
Nico Rosberg on the Booming Business of F1 | All-In Live from Miami
Nico Rosberg, Chamath, Jason, Friedberg
Former 2016 Formula 1 World Champion Nico Rosberg detailed his strategic pivot from racing to venture capital, highlighting significant portfolio investments in AI and software while cautioning against the complexities of the European hardware market. The discussion further analyzed the sport's evolution, noting how rigorous safety innovations and a $130 million budget cap have transformed F1 into a highly profitable enterprise with valuations reaching $6 billion per team. Rosberg emphasized that the sport's recent success stems from a blend of advanced driver training, a Netflix-driven demographic expansion, and the unique convergence of traditional sports with the digital finance ecosystem.
- Milken Institute21 min
A Conversation with Eric Schmidt | Global Conference 2025
Eric Schmidt analyzes the evolving Ukraine conflict as a volatile stalemate driven by massive drone production, automated sensor-to-shooter loops, and the obsolescence of traditional armored platforms like tanks and aircraft carriers. He contrasts Ukraine's rapid, two-week innovation cycles against the Pentagon's sluggish 16-year procurement process, arguing that rigid bureaucratic structures prevent the U.S. from adopting necessary autonomous systems. Schmidt concludes that to counter modern hypersonic threats and future high-intensity warfare, the U.S. must pivot from expensive stationary assets to affordable, internet-prosecuted robotic forces integrated with its domestic startup ecosystem.
- a16z21 min
7 More Healthy Years: What We Can Learn from Super Agers
The proposed healthcare strategy shifts focus from unproven aging reversal to preventing the "big three" age-related diseases through modifiable lifestyle factors and emerging medical technologies. By integrating personalized omics data, AI-driven risk profiling, and novel treatments like GLP-1 drugs and cellular therapies, this approach aims to extend healthspan by seven years for populations globally. This evidence-based framework prioritizes immediate disease mitigation over theoretical longevity, leveraging a 20-year incubation window to fundamentally redefine the standard of care.
- Sequoia Capital38 min
From Data Centers to Dyson Spheres: P-1 AI's Path to Hardware Engineering AGI
Paul Eremenko, Sonya Huang, Pat Grady
P1.ai is launching its AI engineering agent "Archie," which addresses the scarcity of physical design data by synthesizing massive, physics-informed datasets to train specialized models for hardware creation. Initially targeting data center cooling applications in 2025, the system operates as a collaborative team member that orchestrates existing CAD and simulation tools to perform complex design synthesis and error correction at entry-level engineer proficiency. With angel investment from Jeff Dean, the company aims to scale the agent's capabilities from residential cooling to aerospace domains over the next four years, ultimately striving for Engineering AGI defined by self-reflection and domain generalization.
- Y Combinator30 min
How To Design Better AI Apps
Pete Kuhman argues that most current AI software applications are merely legacy interfaces retrofitted with basic chat capabilities rather than being re-engineered as true "action-oriented" agents. He proposes a shift where users can customize or auto-generate system prompts to transform AI from a generic text generator into a tool that executes complex, multi-step workflows across different software environments. Supported by Y Combinator's internal implementation of such agents, this paradigm aims to replace manual prompt engineering with personalized, autonomous systems that handle routine cognitive tasks.
- Goldman Sachs22 min
A world of opportunity: Rob Citrone’s best ideas
Rob Citrone, Tony Pasquariello
Discovery Capital Management founder Robert Citrone outlines a macro strategy delivering 50% annual returns in 2023 and 2024, driven by high-conviction short positions in U.S. regional banks and a bullish thesis on Latin American markets. Citrone forecasts a "fake recession" in the U.S. before a 2026 boom fueled by tax cuts, predicting higher Treasury yields and resisting near-term Fed rate cuts while championing Argentina's fiscal reforms as a prime investment opportunity. The firm combines Julian Robertson's stock-picking with George Soros's risk management, leveraging a unique 24-hour trading cycle and direct global policy access to capitalize on emerging political shifts and market inefficiencies.
- All-In Podcast29 min
Antonio Gracias: DOGE updates, Voter fraud, Finding 'Big Balls' | All-In Live from Miami
Antonio Gracias, Chamath, Jason, Friedberg, David Sacks
Antonio Gracias leads a Doge team implementing a zero-defect operational overhaul of the US government bureaucracy, targeting a 15% reduction in waste and fraud by eliminating NGO spending and restoring full office productivity. The administration combines aggressive voter fraud detection using restored SAVE database protocols with a meritocratic recruitment strategy that prioritizes problem-solving over credentials to secure high-caliber engineering talent. This approach supports a dual-track immigration policy that balances open borders for skilled professionals with strict border sovereignty measures and temporary public service models.
- Milken Institute30 min
Earvin "Magic" Johnson on Legacy, Leadership, and LA's Future | Global Conference 2025
Earvin "Magic" Johnson, Alex Rodriguez, Jason Kelly, Earvin Johnson
At the Milken Conference, Magic Johnson and Alex Rodriguez discussed their transformative mentorship and a portfolio of high-impact business ventures ranging from the Washington Commanders to a pioneering Starbucks franchise. Johnson detailed his strategy of securing institutional capital by over-performing on early real estate deals and outlined his leadership philosophy centered on strategic planning, authentic player relationships, and an unwavering winning culture for the LA Dodgers and other owned teams. The dialogue concluded with an emphasis on leveraging athletic experience to mentor the next generation while measuring success by philanthropic impact rather than revenue alone.
- Goldman Sachs42 min
Harvard’s Raj Chetty on upward mobility in America
Research by Dr. Raj Chetty and the Opportunity Atlas team reveals a sharp decline in intergenerational income mobility, with the likelihood of children out-earning their parents dropping from 92% for the 1940 cohort to roughly 50% for those born in the mid-1980s. The analysis identifies four primary drivers of upward movement, with cross-class social capital acting as the strongest predictor, while highlighting successful local interventions like Charlotte's $160 million investment and Vaughan College's model that combines high access with strong technical outcomes. These findings suggest that targeted strategies integrating financial aid with social support can effectively reverse trends of regional inequality without relying solely on broad federal policy changes.