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  1. All-In Podcast29 min

    #AIS: Opening chat with Miami Mayor Francis Suarez

    Francis Suarez, Yung Spielburg, Calacanis, Friedberg, Henry Belcaster, Dylan Jardon, TheZachEffect, Chamath Palihapitiya, David Sacks

    The "All-In" podcast hosts reunited in Miami for an in-person episode that featured Mayor Francis Suarez detailing the city's aggressive economic strategy, which leverages low taxes and cryptocurrency adoption to cut homelessness by 90% and reduce homicide rates by 63%. During the broadcast, the hosts also apologized for previous interpersonal tensions and engaged in extensive banter while critiquing San Francisco's leadership as Suarez outlined a vision to overtake the former tech capital in venture capital volume within two years. The discussion concluded with broader geopolitical analysis and speculation regarding Suarez's potential 2032 presidential run, framing the city's growth as part of a larger national shift from industrial to digital dominance.

  2. Goldman Sachs31 min

    Jon Moeller, President/CEO of Procter & Gamble

    Jon Moeller, Alison Mass

    New CEO John Moeller is leading Procter & Gamble through a strategic restructuring that decentralizes decision-making into focused markets while redefining sustainability as a core driver of innovation rather than a compliance obligation. The company is addressing permanent macroeconomic shifts by overhauling its supply chain to achieve "Supply 3.0" and committing to net-zero emissions by 2040 through open-source recycling technologies and optimized packaging. These operational changes have already accelerated U.S. growth rates to 8%, restored double-digit performance in China, and eliminated widespread regional profitability losses across the global portfolio.

  3. Goldman Sachs25 min

    What’s Behind the Tech Sell-Off?

    Brook Dane, Peter Callahan, Allison Nathan

    Following a valuation correction comparable to the 2000 dot-com bust, the technology sector is undergoing a cyclical retrenchment driven by structurally higher interest rates that have compressed multiples for software and semiconductor stocks. While hedge funds have de-leveraged and capital flows have reversed, institutional buyers like Goldman Sachs are accumulating assets at five-to-seven-year lows, targeting resilient sub-sectors such as cybersecurity and AI-driven semiconductors. This strategic repositioning anticipates a market recovery in 2023 and beyond as inflation falls and management teams align operations with a normalized macroeconomic environment.

  4. 20VC with Harry Stebbings42 min

    Keith Rabois: The End of Woke Capitalism; Time Allocation Tips; Silicon Valley vs Miami | 20VC #891

    Keith Rabois, Mike Moritz, Vinod Khosla

    Venture capital insights differentiate early-stage "art-like" investments from later-stage "greater fool" dynamics, emphasizing that multi-stage funds like Founders Fund can sustain contrarian strategies while single-tranche investors must rely on derivative consensus for future funding. The discussion highlights shifting market conditions where in-person collaboration is prioritized over remote work, and geographic capital is migrating away from Silicon Valley toward hubs like New York and Miami due to safety and network concerns. Key financial takeaways include the necessity of focusing time only on high-leverage winners, avoiding reliance on public market comparables for early ventures, and recognizing that valuation cycles are driven primarily by inflation and interest rate environments.

  5. All-In Podcast40 min

    #AIS: FiveThirtyEight's Nate Silver on how gamblers think

    Nate Silver, Chamath, Calacanis, Friedberg, Zach

    FiveThirtyEight Editor-in-Chief Nate Silver explores the intersection of gambling, venture capital, and risk management in an in-progress book featuring insights from elite poker players and founders. The work analyzes how high-stakes decision-makers leverage probabilistic thinking, structured processes, and disciplined intuition to navigate uncertainty and extract value in volatile environments. Beyond his research, Silver addresses critical political challenges, including the risks of constitutional crisis in the 2024 election and the broader societal impacts of polarization on government capacity.

  6. All-In Podcast32 min

    #AIS: Divvy Homes CEO Adena Hefets breaks down the state of the US housing market

    Adena Hefets, Chamath, Calacanis, Friedberg, Adina

    Divi Homes addresses the stark wealth inequality driven by asset appreciation and restrictive lending standards by offering a non-traditional homeownership model that allows customers with limited down payments to build equity. Operating across sixteen major markets with a customer base comprising 50% people of color and 80% female-led households, the company has achieved a 51% purchase success rate among participants who complete its three-year term. Funded by a recent $200 million Series investment from Tiger Global, Divi projects a path to profitability with an all-in margin near 25% while navigating a supply-constrained housing market.

  7. Y Combinator22 min

    How To Deal With Setbacks

    Dalton Caldwell, Michael Seibel

    This analysis reframes startup setbacks as an unavoidable structural element rather than a sign of failure, challenging the "movie analogy" that suggests a single victory resolves all challenges. It outlines common adversity categories including investor rejections, co-founder friction, and legal threats while introducing tactical frameworks like the "Worst Case" inventory to help founders distinguish between catastrophic failure and recoverable operational hiccups. By mastering their reaction to these inevitable punches, founders can establish a resilient cultural blueprint that transforms adversity into a stabilizing force for the entire organization.

  8. Goldman Sachs41 min

    Ryan Watts, CEO and Co-Founder of Denali Therapeutics

    Ryan Watts, Amit Sinha

    Founded by CEO Dr. Ryan Watts in 2015, Denali Therapeutics is leveraging proprietary blood-brain barrier technologies and genetic insights to accelerate clinical-stage programs for Alzheimer's, Parkinson's, and ALS. The company is currently initiating pivotal late-stage trials for Parkinson's and Hunter syndrome while prioritizing preventative strategies and shorter-term milestones in lysosomal storage diseases to validate its pipeline. By combining this technical approach with a culture that accepts failure as part of discovery, Denali aims to shift neurodegenerative treatment from late-stage intervention to early disease prevention within the next decade.

  9. Y Combinator36 min

    Save Your Startup During an Economic Downturn

    Dalton Caldwell, Michael Seibel

    This framework defines the critical distinction between "default alive" startups, which can reach profitability before exhausting cash, and "default dead" companies facing imminent extinction without new funding. It identifies the fatal pinch as a common trap where founders increase burn rates due to investor pressure or misaligned incentives, often exacerbated by media biases that mask high fundraising failure rates. To escape this cycle, the analysis advocates for immediate operational discipline, such as drastic headcount and ad spend reductions, citing Justin.tv's rapid transition from burning $250,000 monthly to generating $1.2 million in profit as a proven recovery model.

  10. Goldman Sachs28 min

    The Road to 2050: Balancing Climate Goals with Energy Security

    Kara Mangone, John Goldstein, Allison Nathan

    Amidst geopolitical shifts and energy security concerns, the global financial sector is transitioning ESG from a broad screening metric to a core investment strategy focused on nuanced company analysis and resilience. Major asset owners maintain their net-zero commitments despite market volatility, driving nearly 90% of global GDP into climate-aligned frameworks while capital discipline prioritizes prudent investment timing over divestment. To address critical funding gaps, institutions like Goldman Sachs are leveraging public-private partnerships to mobilize private capital, supported by a strategic pivot toward standardized progress metrics and "EBITDA of decarbonization" that track execution over lagged emissions data.

  11. Goldman Sachs29 min

    Joe Bae, Co-CEO of KKR and Founder of The Asian American Foundation

    Joe Bae, Alison Mass

    KKR Co-CEO Joe Bae outlines the firm's expansive Asian strategy, which now accounts for a quarter of the company's business through diversified infrastructure and private credit investments targeting a millennial demographic. Amidst macroeconomic headwinds like inflation and geopolitical shifts, Bae emphasizes supply chain resiliency and a balanced energy transition while leveraging KKR's localized workforce to navigate global risks. Beyond finance, he details the establishment of the Asian American Foundation to dismantle the model minority myth and drive systemic community support through corporate advocacy and educational initiatives.

  12. Goldman Sachs28 min

    How China’s ‘Perfect Storm’ and Economic Headwinds Are Affecting Markets and Investors

    Kinger Lau, Hui Shan, Alison Nathan

    Goldman Sachs analysts analyze China's current economic stagnation driven by Omicron lockdowns and a severe property downturn, noting that structural constraints and geopolitical tensions limit the government's ability to stimulate growth through traditional methods. Despite these headwinds forcing a downward revision of long-term growth forecasts to 4-5%, the firm argues that significant risks are already priced into equities trading below 10x forward earnings, suggesting a constructive six-to-twelve-month outlook. Investors are advised to align portfolios with policy-supported sectors like semiconductors and green energy, anticipating potential valuation recovery contingent on a soft landing and avoided global recession.

  13. Goldman Sachs27 min

    Jean Case, CEO of The Case Impact Network and Chairman of the National Geographic Society

    Jean Case, Asahi Pompei

    Jean Case outlines the critical distinction between impact investing and ESG frameworks while addressing SEC transparency concerns and the urgent need for "greenwashing" prevention as trillions of dollars transfer to Millennial and Gen Z investors. She highlights a shifting market where diverse leadership teams drive superior returns and where fossil fuel strategies are evolving from divestment to active engagement, particularly amidst geopolitical pressures like the Ukraine crisis. Case illustrates these concepts through App Harvest's vertical farming success and personal reflections on navigating career risks, ultimately advocating for a strategic pivot to "fail forward" when community alignment is compromised.

  14. Goldman Sachs20 min

    Changes at the Top: Spinoffs, Separations and Restructurings

    Ben Snider, David Dubner, Allison Nathan

    Amidst slowing U.S. growth and persistent inflation, the S&P 500 is shifting valuation focus toward high-profit-margin companies, driving a surge in corporate restructuring activities. Global spinoff volume has doubled the five-year average to over $100 billion as management teams prioritize portfolio rationalization and capital allocation efficiency. While transaction structures range from initial-step IPOs to spin-mergers, Goldman Sachs forecasts this trend will persist through 2022 as firms seek to optimize operations against sustained economic headwinds.

  15. All-In Podcast38 min

    E76.5: Food shortage, China's grand plan, inflation, French election plus an All-In Summit preview

    Chamath, Calacanis, Friedberg, David Sacks, Jason

    The inaugural All-In Summit in Miami will feature confirmed speakers such as Palmer Luckey and Keith Rabois alongside sought-after guests like John Mearsheimer and Peter Thiel, who will engage in structured dialogues on topics ranging from global food security and China's geopolitical leverage to macroeconomic inflation and payment network disruption. The three-day event utilizes a new format of solo presentations followed by Socratic discussions to address critical issues including the potential for regime instability in Europe and the dismantling of financial duopolies. Held May 15–17, the sold-out conference combines this substantive programming with themed social events while encouraging diverse viewpoints to foster open debate on emerging geopolitical and technological trends.