Latest Interviews
Showing 1666–1680 of 3,505 transcripts.
Clear all filters- All-In Podcast1h 14m
E65: VC markup dynamics, Russia/US tensions over Ukraine, Altos Labs raises $3B, Stripe mafia & more
Chamath, Putin, Obama, Bill Ackman, Yamanaka, Jason, David Sacks, David Friedberg
Investors David Friedberg, Jay Hogue, Bill Gurley, and Chamath Palihapitiya analyzed current market volatility, venture capital valuation mechanics, and geopolitical risks while debating the strategic separation of long-term investing from short-term trading. The panelists contrasted the structural disincentives for marking down portfolio companies with a consensus that supply chain disruptions, rather than interest rates, currently pose the primary threat to the US economy. Looking forward, the group identified opportunities in fundamentally strong growth stocks despite sector corrections, warned against NATO expansion escalating the Ukraine conflict, and predicted a rapid resolution to global supply bottlenecks alongside a paradigm shift in biotech age reversal research.
Snowflake CEO Frank Slootman on How To Narrow The Focus and Increase The Quality | Full Interview
Frank Slootman, Harry Stebbings
CEO Frank Slootman advances a career strategy prioritizing company trajectory over individual merit, a philosophy that guided his impulsive 2019 transition to lead Snowflake during a period of organizational revitalization. His execution framework mandates extreme focus, rapid decision-making, and a rejection of traditional performance reviews in favor of high-conviction resource allocation and aggressive compensation calibration. Furthermore, Slootman advocates for hiring maladjusted yet empathetic talent while fostering a culture of rapid failure correction where leaders maintain high anxiety to ensure competitive vigilance and strategic autonomy.
Chris Sacca's True Unfiltered Opinion on Facebook and Softbank | Full Interview
Chris Sacca, Harry Stebbings, Crystal, Bill Gurley
Venture capitalist Chris Saka transitions from early successes at Photo Bucket and Twitter to founding Lower Carbon, a climate tech firm targeting gigaton-scale decarbonization through fusion and industrial chemistry. His investment thesis prioritizes unit economics and diverse teams, while his management philosophy enforces rigorous hiring standards and conflict resolution techniques to avoid the pitfalls of sudden wealth. Saka further leverages the firm to support HBCUs and challenges industry norms by advocating for solar radiation management as a necessary emergency measure alongside long-term clean energy transitions.
- All-In Podcast1h 25m
E63: Insurrection indictments, human rights in the US and abroad, groundbreaking MS study and more
Chamath, Calacanis, Friedberg, Phil Hellmuth, Jason, Walensky, David Sacks
David Sacks argues that the media's overemphasis on January 6th constitutes political threat inflation that risks a Republican landslide by distracting from economic concerns, while simultaneously calling for bipartisan reforms to the Electoral Count Act and relaxed accredited investor regulations to foster wealth creation. The discussion further features a debate between Chamath Palihapitiya and Jason Calacanis regarding whether the United States should prioritize domestic human rights crises or global atrocities like the treatment of Uyghurs, contrasting with David Friedberg's analysis of post-pandemic economic trends and scientific breakthroughs linking Epstein-Barr virus to Multiple Sclerosis. These varied segments collectively examine how political strategy, policy legislation, and biotechnology advancements intersect to shape current societal and economic landscapes.
- All-In Podcast1h 7m
E62: Elizabeth Holmes verdict, fraud origins & takeaways, navigating "The Great Markdown" & more
Elizabeth Holmes, Chamath, Calacanis, Friedberg
Elizabeth Holmes was convicted on four counts of fraud for falsely claiming military partnerships and marketing a blood-testing technology that physical science experts deem impossible to execute at scale. The discussion further analyzes how media hype and a lack of venture capital due diligence allowed these deceptions to flourish while current market corrections force private unicorns to confront severe valuation gaps and liquidity crunches. In response to the downturn, founders are urged to prioritize positive cash flow and operational efficiency over hyper-growth, signaling a potential consolidation of venture capital power among a select few mega-firms.
- Jane Street1h 23m
Memory Management with Stephen Dolan
Stephen Dolan, KC Sivaramakrishnan, Ron Minsky, Mark Mandelmann, Simon Hughes, Matt Sullivan, Mark Blyther, Paul Lewisohn, Simon Verstraeteker
Stephen Dolan discusses advanced optimizations in the OCaml language, detailing how generational, incremental garbage collection and software pre-fetching reduce memory access latency by up to 90%. He introduces local types and unboxed representations to enable safe stack allocation and native memory layouts, thereby eliminating heap overhead for temporary values while maintaining automatic memory safety without manual lifetime annotations. The presentation concludes with a roadmap for integrating multi-core garbage collection and lifting GC barriers to support denser data structures, balancing performance with ergonomic simplicity.
- The Diary Of A CEO1h 4m
Jordan Peterson: How To Become The Person You’ve Always Wanted To Be | E113
Jordan Peterson, Stephen Bartlett
Psychologist Jordan Peterson outlines a philosophy of existential responsibility, arguing that individuals must abandon social personas to pursue truth and self-improvement through structured struggle rather than the pursuit of happiness. He details specific protocols for personal development, including nightly self-audits and assertive career negotiation tactics, while critiquing remote work and pandemic policies as threats to embodied human experience and individual liberty. Ultimately, Peterson and interviewer Stephen Bartlett commit to using their platforms to model radical truth-telling as the necessary foundation for a healthy society and the salvation of humanity.
- All-In Podcast1h 22m
E61: 2022 Predictions! Business, politics, science, tech, crypto, & more
Calacanis, Friedberg, Chamath Palihapitiya, David Sacks, Jay Cal
In a candid discussion featuring Jason Calacanis, David Sacks, Chamath Palihapitiya, and Ben Freeberg, participants detailed a COVID-19 superspreading event at Sax's party while debating the biological and geopolitical winners and losers of the 2022 landscape. The group forecasted political shifts including Ron DeSantis's re-election and Vladimir Putin's strategic gains, alongside economic predictions favoring small businesses, biotech innovation, and battery metals over traditional payment processors like Visa. Beyond these macro trends, the conversation extended to intense ethical debates regarding animal agriculture, media narrative shifts, and specific industry disruptions such as the potential rise of decentralized finance.
- Lex Fridman1h 8m
Albert Bourla: Pfizer CEO | Lex Fridman Podcast #249
Host Alex Friedman engages Pfizer CEO Albert Bourla to dismantle pandemic-era polarization by detailing the company's $2.3 billion strategic gamble and the rigorous, transparent regulatory processes that secured global approval for its vaccines. Bourla clarifies the scientific realities behind the record-breaking development timelines, addresses controversies regarding data transparency and workforce mandates, and outlines Pfizer's capacity to rapidly adapt manufacturing for future variants or new antiviral therapies like Paxlovid. Through this dialogue, the discussion moves beyond conspiracy theories to focus on the intersection of high-stakes financial investment, strict safety protocols, and the human imperative to bridge trust gaps through empathetic science communication.
- All-In Podcast1h 28m
E59: Twitter's content warning algo, equity audits, politicians trading stocks, Fed's next move
Elizabeth Warren, Elon, Jeremy Strong, London Breed, Jason Calacanis, David Sacks
In a recent episode of the "All In" podcast, Chamath Palihapitiya, David Sacks, and their co-hosts address the Federal Reserve's accelerated tapering plan while critiquing House Democrats' proposed racial equity audits as paternalistic grifts that threaten innovation. The panelists also analyze Omicron's high transmissibility against lower severity, predicting a political shift away from strict lockdowns as the pandemic becomes endemic, and discuss the burgeoning mainstream potential of mRNA technology for treating cancer. Furthermore, the discussion covers emerging tensions in tech moderation, bipartisan failures in congressional insider trading enforcement, and the potential for a "red wave" in the 2022 midterms driven by voter fatigue with radical progressive policies.
- Goldman Sachs55 min
Dr. Scott Gottlieb, Author of “Uncontrolled Spread” and Former FDA Commissioner
Dr. Scott Gottlieb, Charmaine Mosavar-Rahmani
Dr. Gottlieb discusses the Omicron variant's rapid transmission and reduced severity in South Africa while arguing that booster shots provide sufficient protection against severe disease without the need for immediate variant-specific vaccines. He outlines a shift toward endemic management strategies, emphasizing seasonal vaccination, improved air filtration, and the distribution of home diagnostics as key components of future pandemic preparedness. The analysis further critiques historical data suppression and institutional hesitation, calling for a national security approach to building resilient public health infrastructure.
- Milken Institute58 min
Antibiotic Resistance and Chronic Disease: Understanding the Challenges and Some Possible Solutions
Amanda Jezek, Jonathan Daniels, David Greenberg, Thomas Heyman, Kathy Talkington, Mark Williams, Tom Heyman
Hosted by Faster Cures in partnership with the Infectious Disease Society of America and other key organizations, this webinar examined the critical market failure hindering new antibiotic development and highlighted its severe impact on cancer, cystic fibrosis, and transplant patients. Panelists presented data showing thousands of annual deaths from antimicrobial resistance while advocating for the "Pasteur Act," a policy designed to de-link financial rewards from sales volume to incentivize the creation of novel drugs for critical pathogens. The event concluded by urging stakeholders to share personal stories and sign a letter to Congress to drive legislative action and secure funding for both antibiotic stewardship and research.
- All-In Podcast1h 21m
E58: November's CPI, preparing for a downturn, macro outlook, Better.com's botched layoffs & more
Chamath, Calacanis, Friedberg, Jussie Smollett, David Sacks
Prominent investors and analysts debated the accelerating 6.8% inflation and structural labor shortages at an event featuring Bill Ackman, Chamath Pillay, and Jay Calacanis, who criticized the federal government's fiscal mismanagement and the inefficiency of current capital allocation models. The discussion highlighted the sharp correction in tech valuations and the fallout from corporate missteps like the Better.com layoffs as evidence of a shifting market environment driven by rising interest rates. Looking ahead, the panelists offered diverging forecasts on whether the economy faces a soft landing or a prolonged slide while identifying the creator economy as a potential source of new employment opportunities.
- Goldman Sachs1h 1m
Watch Live: 2021 Goldman Sachs Gives Analyst Impact Fund Finals
Brooke Farrelly, Carli Gogol, Sidney Mitchell, Zac Sicher, Filip Jedmo, Jake Lewis, Daniel Mayers, Aoife O'Halloran, Tilly Thatcher, Srushti Deshmukh, Anagha Gurumurthy, Aditi Kulkarni, Nitiksha, Shreya Srikanth, Will Elia, Max Pivonka, Sara Rogers, Julian Sanchez, Erica Leslie, Julian Salisbury, David Solomon, Dennis Coleman, Asahi Pompei, Emmanuel Oniyuku, Liz Martin, Dan, Ate Latiranta, Lydia Finnegan, Leela, Preston L. James II, Madison, Simone, Nicole Esposito, Ian Drayton, Carrie Haleo, Rachel Schneider, Claire Thompson, Kia Williams, Brad
The sixth iteration of the Goldman Sachs Analyst Impact Fund brought together 1,600 colleagues to compete for grants supporting 300 non-profits, with four finalist teams presenting proposals to judges including David Solomon. Lime Connect won the top prize for its initiative to bridge the employment gap for people with disabilities, while Hello World, Div Inc, and Prasarana Trust secured second, third, and fourth place respectively, with Prasarana also receiving the $25,000 Fan Favorite award. The event successfully aligned the firm's culture of entrepreneurship with tangible outcomes, including a projected $700 billion potential GDP increase in India and significant strides in global digital access and minority entrepreneurship.
- All-In Podcast1h 18m
E57: Understanding Omicron, tech stocks plummet, VC's great resignation, Jack Dorsey's departure
Jack Dorsey, Chamath, Calacanis, Friedberg, Mike Bloomberg, David Sacks
Hosts David Friedberg, David Sacks, Chamath Palihapitiya, and Jay resumed their podcast from Miami, where they analyzed the Omikron variant's high transmission rate and potential for mild symptoms while debating the economic necessity of avoiding lockdowns. The group examined a 30% to 50% compression in tech stock valuations driven by shifting investor horizons and structural inflation, noting a cultural pivot among venture capitalists toward climate tech and away from purely financial gains. Additionally, the conversation covered critical social issues including San Francisco's decline, calls for immigration reform to retain global talent, and concerns over free speech protections following recent leadership changes at Twitter.