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  1. Milken Institute1h 1m

    Where Is the Next Cure? | Global Conference 2024

    Alice Park, Noubar Afeyan, Aloe Blacc, Daphne Koller, Samarth Kulkarni, Pablo Legorreta

    Leading biotech executives and researchers are redefining the industry by shifting from chronic small-molecule management to precise, curative systems-based therapies like CRISPR and mRNA platforms. This transition, fueled by artificial intelligence and a "reverse translation" innovation model, has accelerated clinical timelines while projecting a $100 billion market for GLP-1 drugs and new organ-editing solutions. Despite regulatory hurdles and high initial costs for treatments like sickle cell gene editing, stakeholders anticipate that maturing technologies and scalable manufacturing will eventually democratize access to these transformative medical breakthroughs.

  2. Milken Institute1h 0m

    The Corporate Compass: Charting the Role of the CEO | Global Conference 2024

    Andy Serwer, Carmine Di Sibio, Jessica Sibley, Raj Subramaniam, David Zaslav

    CEOs from EY, Time Inc., FedEx, and Warner Bros. Discovery convened to address the intensifying challenges of stakeholder capitalism, geopolitical instability, and rapid technological disruption. The leaders detailed transformative shifts in their respective business models, such as FedEx's pivot to supply-chain technology and Time Inc.'s strategic move to a B2B framework, while highlighting how artificial intelligence is driving efficiency and reshaping content distribution. Despite varying cultural and governance hurdles, including EY's abandoned audit split and labor negotiations across industries, the panel emphasized that aligning CEO compensation with performance and leveraging trusted brands will remain central to navigating a complex future.

  3. Milken Institute1h 1m

    Rewriting the Rules of Global Conservation | Global Conference 2024

    Justin Worland, Eron Bloomgarden, Iván Duque Márquez, Jennifer Morris, Wendy Schmidt

    The event convenes global leaders and financial experts to address the crisis of 70% global wildlife decline by examining the "30x30" pledge to protect land and oceans by 2030, highlighted by Colombia's successful expansion of protected areas. Through analysis of market mechanisms like carbon pricing, debt-for-nature swaps, and the LEAF Coalition, the discussion outlines strategies to mobilize the trillions of dollars required to transition from extraction to regenerative economic models. The proceedings emphasize that achieving these targets depends on integrating indigenous land rights, deploying technology for transparent data, and aligning political will with private capital to prevent the Amazon from reaching a critical tipping point.

  4. Milken Institute56 min

    AI's Ethical Frontier: Responsible Regulation...by Whom? | Global Conference 2024

    Jo Ling Kent, Rob Bonta, John B. Quinn, Rob Silvers, . will.i.am, Frankie Williams, Felicia

    Undersecretary Rob Silvers and California Attorney General Rob Bonta outlined a dual strategy of federal oversight and state-level enforcement to secure critical infrastructure and curb AI harms, including the creation of a new DHS safety board and active litigation against major tech firms. The discussion highlighted growing legal concerns regarding data sovereignty, child safety, and algorithmic manipulation, while advocating for a shift toward risk-based, EU-style regulations that reverse the burden of proof for AI-caused injuries. Despite skepticism about comprehensive federal privacy laws, the panel emphasized that California will likely lead regulatory development through diverse stakeholder inclusion and strict consumer protection measures.

  5. Milken Institute53 min

    Africa's Youth is Using Technology to Solve Africa's Most Pressing Problems | Global Conference 2024

    Dan Keeler, Ramadan Ameen, Maya Horgan Famodu, Yolanda Mabuto, Walter Pacheco, Fred Swaniker

    A panel of industry leaders and investors analyzed Africa's transformative potential, driven by a young, mobile-connected population and surging venture capital flows that have facilitated significant fintech exits and the scaling of global talent pipelines. Discussions highlighted strategic shifts toward execution over intellectual property protection, the democratization of capital through digital asset tokenization, and the deployment of AI and drone technology to revolutionize healthcare infrastructure in nations like Rwanda. Experts concluded that bridging the skills gap through grassroots technical education and exporting digital labor are critical to unlocking economic sovereignty and ensuring sustainable growth for the continent's projected workforce.

  6. Milken Institute1h 0m

    Powering the Future: Energy Storage, Delivery, and a Modern Grid | Global Conference 2024

    Gregory Zuckerman, Donnel Baird, Nardos Bekele-Thomas, Pedro Pizarro, Andrew Ponec, Karen Wayland

    A pivotal panel discussion highlighted the accelerating global transition toward a modernized power grid driven by surging demand from AI, manufacturing repatriation, and electrification. Key figures outlined massive investment requirements, including a $370 billion California requirement and a $1.3 trillion need for African energy modernization, alongside technological shifts toward thermal batteries, extended nuclear lifespans, and SMRs. Experts concluded that overcoming regulatory bottlenecks and reforming market rules are essential to aligning infrastructure development with the urgent goals of decarbonization and grid resilience.

  7. Milken Institute1h 3m

    Data-Driven Solutions to Advance the American Dream | Global Conference 2024

    Rachel Goslins, Raj Chetty, Jon Clifton, Brian Hooks, Poppy MacDonald, John

    Hosted by Rachel Goslins of the Milken Center, this panel featured experts Raj Chetty, Poppy Gentry, Brian Sheth, and John Pollack to analyze the decline in American economic mobility using large-scale data from tax records, government sources, and social networks. The discussion highlighted a sharp drop in intergenerational wealth transfer since the 1940s and exposed how geographic variance, low social capital, and gaps in wealth measurement contribute to the widening prosperity gap. By integrating public perception surveys with "customer-first" philanthropy models, the session concluded that improving mobility requires redefining the American Dream to prioritize freedom and opportunity while leveraging private financial data to guide targeted policy interventions.

  8. Milken Institute1h 4m

    Genes, Galaxies, & Discoveries: Engineering New Advances in Modern Science | Global Conference 2024

    Susan Karlin, Steve Altemus, Cara Altimus, Josh Denny, Reed Jobs, Kathryn North, Sue Carlin, Cara Ultimates

    A panel of experts analyzes a global paradigm shift where isolated research initiatives evolve into collaborative "moonshot" projects driven by commercial space markets and large-scale biomedical data sharing. Key figures discuss how fixed-price government contracts and risk-tolerant philanthropy have catalyzed private sector innovation in lunar economies, while the "All of Us" program and GA4GH work to standardize diverse genomic data for precision medicine. Looking forward, these converging sectors aim to reduce sequencing costs to $100, expand gene therapies to complex diseases, and implement "learning health systems" that integrate real-time data into clinical practice.

  9. Goldman Sachs22 min

    FedEx founder & chairman Fred Smith on transforming global logistics

    Fred Smith, David Solomon

    FedEx founder Fred Smith established a revolutionary hub-and-spoke logistics network grounded in military matrix management and the "People, Service, Profit" philosophy to scale operations globally while retaining key talent. Under his leadership, the integration of real-time tracking with a massive air and ground fleet enabled the company to handle approximately six percent of U.S. GDP and provide unique economic data insights into consumer trends. Today, Smith emphasizes that maintaining defensible competencies in artificial intelligence and digital transformation is critical for navigating the rapid market shifts that threaten legacy business models.

  10. Milken Institute1h 0m

    Bold Proposals for Protecting the Free-Enterprise System while Closing the Wealth Gap | GC 2024

    Michael Milken, John Hope Bryant, Brad Gerstner, Teresa Ghilarducci

    At a May 2024 Milken Institute panel moderated by Michael Milken, experts including Stephen Mnuchin, Brad, John Hope Bryant, and Theresa outlined a consensus strategy to protect the free enterprise system by replacing wealth taxes with universal financial literacy and private capital access. The discussion detailed specific legislative and corporate initiatives such as the Retirement Savings for American Act and the "Invest America" proposal, which aim to automatically enroll millions of workers in retirement accounts and establish seed accounts for newborns to counteract economic inequality. Proponents argue these structural reforms, alongside private equity expansion, are essential to prevent national decline and ensure that the impending intergenerational wealth transfer builds lasting capital rather than dependency.

  11. Milken Institute53 min

    Systems Finance for Sustainable Development | Global Conference 2024

    Simon Winter, Jake Cusack, Rini Greenfield, Madhur Jain, Daniela Kandel, Jake Levine

    A panel of public and private sector leaders convened to launch the Smallholder Action Coalition on Climate Adaptation, a multi-pillar initiative designed to coordinate finance and technology for one million farmers in climate-vulnerable regions like Bangladesh. The coalition leverages innovations from entities such as Varaha Ag and Evergreen to stack carbon sequestration with agricultural diversification, aiming to validate a business case that could eventually scale to five million farmers and mobilize one billion dollars. Financial experts emphasized that overcoming capital gaps requires blended finance structures and aggregation strategies to lower risk premiums and address the three-trillion-dollar shortfall in emerging market climate funding.

  12. Milken Institute1h 3m

    Silver Threads: Weaving the Caregiving Tapestry | Global Conference 2024

    Richard Lui, Yvette Nicole Brown, Hon Pak, Naimish Patel, Dor Skuler, Kai Walker, Ellicote

    Moderated by Richard Louie, the "Silver Threads" panel convened entertainment, technology, and finance leaders to address the U.S. caregiving crisis affecting 53 million unpaid caregivers who collectively represent $3/4 trillion in unrealized economic value. Experts highlighted that while financial models remain misaligned, innovative solutions like Intuition Robotics' AI companion Ellie Q are beginning to offer scalable, cost-effective alternatives to traditional institutional care. The session concluded with a consensus on the urgent need to normalize the caregiver identity and reform policy to support the 30 million workers currently navigating the dual demands of employment and family responsibility.

  13. Milken Institute58 min

    Innovators Rethinking Criminal Justice Systems | Global Conference 2024

    Zack Carpenter, Baz Dreisinger, Hilton Freund, Jessica Hicklin, Teresa Hodge, Ari Melber, Alex Spiro

    Global and domestic speakers including Jessica Hicklin, Theresa Hodge, and Dr. Baz convened to address the $250 billion U.S. criminal justice crisis and its disproportionate impact on racial minorities and the 50% rise in female incarceration worldwide. These innovators argued that data-driven reforms, such as implementing earned-time credits and sport-based skill building, could prevent 350,000 years of unnecessary incarceration while addressing a projected 22 million worker shortage in the energy sector. Despite significant barriers like funding mismatches and political volatility, the event emphasized shifting from "second chances" to "first chances" to leverage the 95% of released prisoners who will integrate into the workforce.

  14. Milken Institute1h 2m

    Storytelling for Change: Creating Hope out of Crisis | Global Conference 2024

    Jimmie Briggs, Andrea Bruce, Scott Harrison, Yunghi Kim, Eli Reed, Yoongi Kim

    Prominent photojournalists and social entrepreneurs Yoongi Kim, Scott Harrison, Andrea Bruce, and Eli Reed examined how visual storytelling confronts modern challenges like AI-generated disinformation and funding crises while driving tangible policy and humanitarian outcomes. The panelists detailed specific successes, including Kim's policy-altering documentation of Comfort Women, Charity Water's billion-dollar mobilization through immersive narratives, and Bruce's locally focused publication that achieved near-universal community engagement. Unifying under the belief that ethical, human-centered reporting is essential for democracy, the group emphasized the critical need for sustained public investment in original journalism to preserve truth and foster empathy across a noisy digital landscape.

  15. All-In Podcast12 min

    AI Czar David Sacks Explains the DeepSeek Freak Out

    David Sacks, Chamath, Friedberg

    DeepSeek's release of the open-source R1 reasoning model triggered a trillion-dollar global market decline by accelerating the geopolitical narrative of US-China AI competition and challenging closed-source providers. Although the company's reported $6 million training cost reflects only the final run rather than total expenditures, its innovative algorithmic optimizations on constrained hardware have compressed industry expectations regarding China's technological timeline to just three to six months. This event signals a potential industry shift toward model commoditization, suggesting that value creation may increasingly move upstream to infrastructure or downstream to applications rather than residing solely in the models themselves.