Latest Interviews
Showing 8056–8070 of 9,951 transcripts.
Clear all filters- 80,000 Hours2h 18m
#39 - Spencer Greenberg on the scientific approach to solving difficult everyday questions
Spencer Greenberg, Keiran Harris, Rob Wiblin
Spencer Greenberg updates the portfolio status of four Sparkwave-backed companies while presenting extensive research on intrinsic values, overconfidence calibration, and Bayesian evidence evaluation. His analysis distinguishes how political and demographic groups prioritize different core values and introduces a predictive model for identifying when individuals are likely to overestimate their skills or underestimate difficult tasks. Furthermore, Greenberg demonstrates practical applications of these frameworks through case studies on political collusion, nuclear disarmament, and scientific replication, ultimately advocating for a methodical approach to belief updating that balances prior probabilities with specific evidence.
- 80,000 Hours2h 0m
#38 - Prof Ng on anticipating effective altruism decades ago & how to make a much happier world
Prof Ng, Yew-Kwang Ng, Keiran Harris, Rob Wiblin
Yu-Kwang Ng, an economist who independently pioneered core effective altruism concepts in the 1990s, advocates for a hedonistic utilitarian framework that prioritizes subjective well-being as the sole intrinsic moral value to guide public policy. His research proposes specific interventions ranging from high progressive taxation to correct relative competition and environmental externalities, to the development of brain stimulation technologies and welfare biology for mitigating wild animal suffering and existential risks. By rejecting traditional deontological and capability-based ethical systems in favor of cardinal utility comparisons, Ng urges a global shift toward policies that maximize net welfare across current and future generations.
- 80,000 Hours1h 44m
#37 - GiveWell picks top charities by estimating the unknowable. James Snowden on how they do it.
James Snowden, Keiran Harris, Rob Wiblin
Founded a decade ago by Holden Karnofsky and Ellie Hassenfeld, GiveWell directs approximately $100 million annually to nine evidence-backed charities in international development after applying rigorous cost-effectiveness and transparency criteria. The San Francisco-based organization recently expanded its portfolio to include five new top recommendations while navigating internal ethical debates over suicide prevention and evolving its analytical models to account for leverage and funding effects. With a team of over 20 employees focused on an "epistemic culture," the group continues to explore policy interventions and speculative research opportunities beyond traditional direct service models.
- The Economist24 min
The data revolution: privacy, politics and predictive policing
Dr Tom Devlin, Trump, Nick Bowers, Carol Reed, Hal Hodson, David Carroll, Mark Zuckerberg, Jamie Garcia, Hamid Khan, Sergeant David Rich, Anthony, Leo Hu
The event examines how the exponential growth of data generation is transforming healthcare through AI tools like Viz.ai while simultaneously enabling invasive surveillance in consumer marketing, law enforcement, and state control systems. Key case studies include the medical success of stroke detection algorithms, the electoral manipulation via Cambridge Analytica's unauthorized data harvesting, and the controversial implementation of China's Social Credit System. Furthermore, the discussion highlights significant ethical conflicts surrounding predictive policing biases in Los Angeles and the ongoing legal battles to ensure transparency in how personal data is collected and utilized by governments and corporations.
- Y Combinator55 min
A Conversation with Elizabeth Iorns - Advice for Biotech Founders
Former University of Miami assistant professor Elizabeth Irins founded Science Exchange in 2011 to solve scientific market inefficiencies by creating a vetted B2B marketplace that manages over $100 billion in annual outsourced research spend. The platform mitigates information asymmetry and quality issues through rigorous provider vetting and a Reproducibility Initiative that validates experimental results for major pharmaceutical partners like Amgen. Currently serving as a Y Combinator partner, Irins leverages the company's transparent data infrastructure to reshape academic-commercial collaboration while advising a portfolio of hundreds of biotech startups.
- Y Combinator57 min
Running Your Company by Patrick Collison
Patrick Collison, Adora Cheung
Founded by brothers Patrick and John Collison, Stripe began its full-time development in 2010 to revolutionize internet commerce, ultimately securing a public launch in September 2011 after manually installing APIs for 100 production users. Today, the company employs 1,300 staff across nine global offices to process approximately 200 million daily API requests for millions of companies, reaching a $20 billion valuation. The organization has evolved from a consensus-driven model to a structured hierarchy where decision-making authority depends on passionate conviction, enabling it to scale infrastructure that facilitates global economic participation for entrepreneurs from Nigeria to New York.
- Y Combinator48 min
Mathilde Collin on Feature Prioritization and Employee Retention at Front
Mathilde Collin, Craig Cannon, Tuomas Grannas, Jordan Jackson, Tomas Granos, Mark Mandelmann, Gabrielle Tcheyani, KP
Front, a shared inbox collaboration platform founded by Gabrielle Tcheuyani and Laurent, transforms email into a team workflow tool by integrating individual inboxes and external applications like Salesforce and GitHub. The company achieved its initial market traction through content marketing and manual onboarding before securing product-market fit and reaching $1.5 million in ARR by the Series A round. Guided by a "Work Happier" mission, Front prioritizes radical transparency, employee well-being, and a unique product philosophy that discards legacy email structures in favor of fluid conversation threads and automation.
- Goldman Sachs19 min
Peter Fonagy: Combating a Mental Health Crisis
Peter Fonagy, drawing on his personal survival of childhood depression and evolutionary biology, argues that child development depends on community "alloparenting" rather than isolated maternal care, criticizing modern separation policies and industrial family structures. He contrasts these systemic failures with evidence that punitive parenting and excessive educational pressure undermine mental health, while advocating for sensitivity-based discipline and the public skills training necessary to replace current destigmatization efforts. This perspective is further applied to organizational settings where a disconnect between leadership perception and employee reality perpetuates anxiety, highlighting the urgent need for adults to actively regulate emotional environments across both domestic and professional spheres.
- Goldman Sachs9 min
"Catch-Up With David": Lloyd Blankfein
Lloyd Blankfein, David Solomon
Outgoing CEO David Solomon prepares his successor by urging the management of the transition chasm and a strict prioritization of stakeholder obligations over personal entitlement. Drawing on a decade of experience, he emphasizes that leadership demands constant engagement with difficult decisions and utilizes public platforms strictly to serve the firm's interests. Solomon steps down to facilitate a fresh vision, advising the incoming leader to sustain a marathon pace of humility and energy while anticipating his own future shift toward unrestrained personal expression.
- Goldman Sachs23 min
Muffet McGraw: Winning in Women’s Sports
Notre Dame head coach Muffet McGraw reflects on her eight Final Four appearances and two national championships while advocating for women in coaching and challenging media double standards. Drawing on her background as a seven-on-seven pioneer, she details a recruiting philosophy prioritizing character over talent and the strategic implementation of an all-female coaching staff to foster role modeling. Her insights further explore the resilience required to overcome severe team injuries and adversity, exemplified by the 2018 championship run, alongside her observations on the persistent scrutiny female leaders face regarding emotional expression and professional behavior.
- 80,000 Hours2h 5m
#36 - Tanya Singh on ending the operations management bottleneck in effective altruism
Tanya Singh, Professor Bostrom, Tara Mac Aulay, Keiran Harris, Rob Wiblin
An episode featuring Tanya Singh from the Future of Humanity Institute and representatives from the Centre for Effective Altruism addresses the critical shortage of operational talent hindering the scaling of effective altruism organizations. The discussion defines operations as creative problem-solving roles that act as force multipliers for researchers, highlighting open positions at GiveWell, Open Philanthropy, and OORT that require high value alignment and adaptability. With applications for several key roles closing within days, the event outlines the specific skills, such as systems prototyping and automation, necessary for candidates to prevent organizational stagnation in a sector marked by significant growth potential.
- 80,000 Hours1h 23m
#35 - Tara Mac Aulay on the audacity to fix the world without asking permission
Tara Mac Aulay, Keiran Harris, Rob Wiblin
Former CEA CEO and Operations Specialist Tara McCauley leveraged a background in data-driven optimization across sectors like healthcare and humanitarian aid to transform organizational efficiency, notably saving millions at St. Vincent's Hospital and mitigating fatal systemic errors in Bhutan. She applies these lessons at the Centre for Effective Altruism by prioritizing "invisible" infrastructure and a culture where the best argument wins, while advocating for operations as a distinct, high-skill career path essential for scaling mission-critical work. Currently, McCauley is recruiting UK and US Operations Specialists, an Events Specialist, and a CEO Office Project Manager to further build the sector's operational capacity before the application deadline on July 6th.
- Y Combinator40 min
How to Apply and Succeed at Y Combinator by Dalton Caldwell
The event details how applying to Y Combinator serves as a critical strategic exercise that forces founders to clarify business fundamentals while systematically dismantling common misconceptions regarding timing, industry fit, and team requirements. It outlines a rigorous application protocol where completeness, concise storytelling, and demonstrable execution capability outweigh prior experience or networks, emphasizing that the process itself builds skills transferable to scaling the venture. Furthermore, the discussion highlights that the partnership interview functions as a collaborative verification of these metrics rather than a trivia quiz, providing specific feedback loops that encourage strategic re-application based on tangible progress.
- 80,000 Hours2h 19m
#34 - We use the worst voting system that exists. Here's how Aaron Hamlin is going to fix it.
Aaron Hamlin, Edwin Edwards, David Duke, Buddy Roemer, Keiran Harris, Rob Wiblin
The Center for Election Science leverages a $600,000 Open Philanthropy grant to advance voting reform by advocating for Approval Voting as a superior alternative to the flawed First-Past-The-Post system. By targeting municipal ballot initiatives in cities like Fargo and San Francisco, the organization aims to break the two-party duopoly and elect moderate consensus candidates without the complexities of Instant Runoff Voting. This grassroots strategy seeks to scale successful local implementations into state and federal adoption, ultimately reducing political polarization and increasing voter efficacy through a robust, transparent electoral mechanism.
- 80,000 Hours1h 25m
#33 - Dr Anders Sandberg on what if we ended ageing, solar flares & the annual risk of nuclear war
Dr Anders Sandberg, Bryan Caplan, Keiran Harris, Rob Whitlin
Anders Sandberg argues that shifting healthcare investment from symptom treatment to root-cause aging research offers a more cost-effective "longevity dividend" while addressing the political risks of non-aging leadership through institutional term limits. He further warns that uncoordinated adoption of high-stakes technologies creates a "unilateralist curse" and that anthropic bias obscures the true, "disturbingly large" annual probability of global catastrophes like nuclear war. These insights collectively advocate for data-driven risk assessment, interdisciplinary scientific collaboration, and conservative institutional design to navigate the profound uncertainties of extending human life.