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  1. Milken Institute56 min

    AI's Next Chapters: What to Expect from A Transformative Technology

    Becky Peterson, Erkin Adylov, Vijay Doradla, James Golden, Mark Johnson, Robert Kirkpatrick

    Leading experts from the United Nations, industrial AI firms, and data analytics companies convened to outline the transformative potential of artificial intelligence in sectors ranging from global disaster prediction and healthcare to industrial safety and financial compliance. The panel emphasized a strategic pivot toward data philanthropy and differential privacy to mitigate deepfake risks while leveraging real-time behavioral signals to predict crises like food insecurity and disease outbreaks without compromising individual privacy. Concluding with a consensus on global competition, the speakers argued that immediate investment in narrow AI capabilities and workforce upskilling is critical to address demographic shifts in emerging markets and prevent the displacement of labor through human-AI augmentation.

  2. Y Combinator28 min

    Dalton Caldwell - All About Pivoting

    Dalton Caldwell

    Y Combinator partner Dalton Caton defines a true pivot as a strategic shutdown of an existing operation to pursue a superior alternative, distinguishing it from incremental changes or failures born of avoidance. He establishes a decision framework based on opportunity cost and a heuristic comparing progress against excitement, while warning against barriers like the sunk cost fallacy and politeness bias that delay critical transitions. By prioritizing founder-market fit, venture-scale potential, and speed to execution, successful companies like Brex and Retool demonstrate that objectively evaluating ideas through this lens allows founders to declare bankruptcy on failing concepts and rapidly iterate toward product-market fit.

  3. Y Combinator18 min

    Tim Brady - Building Culture

    Tim Brady

    Founders must proactively define the implicit behaviors and core values of early-stage companies, as the first twenty employees establish the cultural DNA that dictates scalability and long-term success. By articulating an inspiring vision and prioritizing externally focused principles, leadership guides hiring decisions to ensure diversity of opinion and alignment with business goals before rapid expansion. This early structural investment prevents the propagation of incorrect behaviors and enables the organization to withstand the challenges inherent in scaling from product-market fit to widespread adoption.

  4. Y Combinator36 min

    Diana Hu on Augmented Reality and Building a Startup in a New Market

    Diana Hu, Craig Cannon

    Diana Hu, an Intel veteran and former Escher Reality founder, discusses the current "installation phase" of augmented reality where infrastructure and developer tooling must be established before widespread consumer deployment. She details how advances in mobile hardware efficiency and 5G bandwidth now make AR viable, advising early-stage founders to prioritize building functional prototypes over proving immediate market fit. Hu further reflects on her transition from startup founder to corporate leader at Niantic, emphasizing that the immigrant experience fosters the risk-taking mindset necessary to navigate the long-term vision required for mixed reality.

  5. Milken Institute1h 3m

    Innovators Shaping Asia

    Gary Liu, Swan Gin Beh, Tony Han, Ming Maa, Teddy Oetomo, Hua Fung Teh

    This event analyzes the explosive growth of Asia's unicorn ecosystem, which now accounts for one-third of global valuations and is driven by a massive, rising middle class across its $2.8 trillion Southeast Asian economy. Case studies from Grab, One Championship, WeRide, and Bukalapak illustrate how leaders leverage hyper-localized strategies, deep government collaboration, and the digitization of the informal economy to navigate diverse regulatory landscapes. By focusing on infrastructure gaps and IP export potential, these companies are transforming the region from a consumer of global technology into a primary source of innovation and market disruption.

  6. Milken Institute57 min

    Filling the Global Infrastructure Gap

    Brian Sullivan, David Bohigian, Jim Yong Kim, Raymond J. McGuire, Hiromichi Mizuno, Angela Rodell, Ray McGuire

    A high-level forum featuring global financial leaders and development officials addressed the critical $2.7 trillion annual infrastructure gap in emerging markets, where private capital currently constitutes a mere fraction of total investment. Participants debated strategies to bridge this divide by aligning impact mandates with mid-to-high teen return expectations while leveraging tools like political risk insurance and the newly rebranded Development Finance Corporation to de-risk projects. The dialogue concluded with a consensus on the necessity of "high-quality" standards, universal ownership frameworks, and specific "dream projects" such as Sahel solar farms to mobilize the trillions of dollars in available global assets.

  7. Milken Institute59 min

    Stand in Your Power: The Mindful Way

    James Doty, Neville Crawley, Laura Dern, Donna Karan, George Mumford, Dan Siegel

    Stanford neurosurgeon James Doty and a diverse panel of experts including Laura Dern, George Mumford, and Donna Karan present a scientific framework demonstrating how structured mind training utilizes neural plasticity to reduce stress, optimize cardiovascular health, and slow cellular aging. The discussion highlights practical applications where daily meditation practice reprograms high-performance individuals, such as Kiva.org CEO Neville Crawley, to overcome chronic anxiety and enhance professional decision-making. By shifting healthcare and business models from fixing deficits to fostering innate potential, these findings advocate for a universal protocol that offers sustainable physiological benefits against the modern epidemics of depression and burnout.

  8. Y Combinator28 min

    Kevin Hale - How to Work Together

    Kevin Hale

    This event applies John Gottman's marital research to startup dynamics, identifying the "Four Horsemen" of relationship failure and attachment styles to help founders optimize long-term partnerships. Experts outline strategic defenses including the "Divide and Conquer" role assignment, nonviolent communication frameworks, and formal disagreement documentation to prevent conflicts over money, time, and vision. The discussion concludes with actionable protocols for conducting Level Three conversations and regularly paying down emotional debt to ensure startup longevity.

  9. Y Combinator29 min

    Kirsty Nathoo - Managing Startup Finances

    Kirsty Nathoo

    Founders are advised to track core financial metrics like burn rate and runway weekly to maintain a "default alive" trajectory toward profitability, using tools like Trevor Blackwell's calculator to model realistic scenarios. The presentation warns against underestimating expenses, misclassifying labor costs, or hiring prematurely, emphasizing that scaling before product-market fit significantly increases failure risk. To secure optimal fundraising leverage, founders should aim for sustained revenue growth on existing capital while reserving Series A financing for when detailed forecasts and proven traction are available.

  10. Milken Institute56 min

    A Conversation with Wilbur L. Ross, Jr., Secretary, U.S. Dept. of Commerce | The American Workforce

    Wilbur L. Ross, Jr., Gerard Baker, Bernard Harris, Jr., Barbara Humpton, Jonathan Sokoloff, John, Wilbur Ross

    The American Workforce Advisory Board, led by Secretary Ross, has secured commitments for 7.5 million apprenticeships to address critical labor gaps caused by a "barbell" demographic and a vocational training deficit. Industry leaders and policymakers are collaborating to shift from a traditional degree-centric model toward merit-based hiring, lifelong retraining, and expanded STEM education to prepare for technological displacement and emerging sectors like space travel. This strategic pivot aims to align the workforce with evolving economic realities by prioritizing digital readiness, soft skills, and streamlined credentialing over obsolete vocational labels.

  11. Milken Institute59 min

    Investing in a New Generation of China

    Timothy Dattels, Goodwin Gaw, Jin Qiu, Jason Tan, Jonathan Woetzel, Yibing Wu

    This event analyzes China's economic transformation from a manufacturing exporter to a consumer-driven powerhouse facing demographic headwinds, while highlighting rapid innovation in AI, fintech, and luxury markets. Panelists identify key investment opportunities in co-living, digital-physical connectivity, and sustainability, alongside regulatory shifts in finance and healthcare that challenge traditional monopolies. The discussion also addresses the geopolitical implications of supply chain diversification, protectionist barriers in health-tech, and the strategic evolution of China's financial infrastructure toward global competitiveness.

  12. Milken Institute58 min

    Pushing the Boundaries of the Final Frontier: Space

    Anousheh Ansari, Peter Diamandis, Bernard Harris, Jr., Steve Isakowitz, Leland Melvin, George Whitesides

    Peter Diamandis, Dr. Bernard Harris, Steve Isakowitz, Leland Melvin, and George Whitesides convened to analyze the transition from government-dominated space exploration to a competitive, multi-planetary future driven by private investment and technological innovation. The panel detailed critical advancements in reusability, AI integration, and life support systems while highlighting how space research directly addresses terrestrial challenges like wildfire management, osteoporosis, and global connectivity. Ultimately, the discussion underscored an urgent shift toward democratizing access to space to foster a unified human perspective and secure economic viability through resource extraction and international collaboration.

  13. Y Combinator7 min

    The Biggest Mistakes First-Time Founders Make - Michael Seibel

    Michael Seibel

    The event outlines critical strategies for startup success, emphasizing that founders must select problems aligned with personal passion and choose co-founders based on pre-existing relationships to ensure long-term commitment. It advocates for rapid product launches within a month to enable user validation, arguing that external distractions like press events often distract from the essential work of shipping an MVP. Furthermore, the discussion highlights the necessity of implementing user analytics and acquiring initial customers through the founder's network to drive effective iteration and growth.

  14. Goldman Sachs16 min

    Darren Walker – President of the Ford Foundation

    Darren Walker, Asahi Pompei

    Darren Walker, President of the Ford Foundation, leverages his decade of private sector experience in capital markets and law to critique structural inequalities he argues threaten American democracy. Drawing on historical data regarding the "War on Drugs" and post-1982 corporate financial shifts, Walker asserts that systemic designs deliberately suppress upward mobility and erode trust in institutions. He concludes by urging professionals to integrate empathy and specific skill sets into for-profit sectors and local community engagement rather than assuming a full career pivot is necessary for social impact.

  15. Milken Institute57 min

    Beyond Crypto's Wild Ride

    Staci Warden, Meltem Demirors, Kathryn Haun, Elizabeth Rossiello, Elizabeth Stark, Katie Couric, Yamiche Alcindor, Amna Nawaz, Tamara Keith, Elizabeth Choe

    A panel of industry leaders and investors from Andreessen Horowitz outlines the evolution of digital assets from speculative instruments into a foundational computing platform and a mechanism for solving global coordination problems. The discussion details how innovations like the Lightning Network are addressing Bitcoin's throughput limitations while emerging use cases ranging from unbanked financial inclusion to machine-to-machine economies drive institutional adoption by entities such as Fidelity and JP Morgan. Despite regulatory hurdles regarding taxation and security risks posed by bad actors, the consensus points toward a 2025 future characterized by mature infrastructure, interoperable systems, and a transformed "internet of value."