Latest Interviews
Showing 3871–3885 of 5,336 transcripts.
Clear all filters- Milken Institute1h 0m
Can America Afford to Retire?
Josh Barro, Andrew Biggs, Marcie Frost, Jarvis Hollingsworth, Dan Houston
A panel of public and private sector leaders, including CEOs from CalPERS and Texas Teachers Retirement System, examines the divergent financial realities of retirement affordability across defined benefit and contribution models. While current retirees enjoy record wealth, the discussion highlights critical structural vulnerabilities in public pension funding assumptions and the longevity risks facing workers in defined contribution plans. Experts propose policy interventions such as federal funding mandates, auto-enrollment mechanisms, and annuity integration to address projected solvency gaps and ensure long-term system stability.
- Milken Institute1h 4m
Open Data, Open Banking: Creating a More Competitive Financial Services Ecosystem
Melissa Koide, Gilles Gade, Sima Gandhi, Sahil Kini, Craig Schachter, Rachel Bronson, Aaron Pakles, Lee Hutter
Moderated by Melissa Coit, a panel of global fintech leaders debated the balance between top-down regulatory frameworks and bottom-up market demands in the evolution of open banking. The discussion highlighted divergent regional models, contrasting India's public infrastructure-driven success with the fragmented, principle-based approach in the US, while addressing the critical need for consumer data ownership and liability clarity. Participants concluded that modernizing legacy core banking systems and establishing clear consent mechanisms are essential to enable real-time data flow and prevent market consolidation from stifling innovation.
- Milken Institute52 min
How Drug Trafficking Is Fueling the Opioid Crisis
Anita Gupta, Michael A. Davis, Lynn Goldman, Adriaan Louw
This event convenes experts to address the escalating opioid crisis, characterized by a 2017 overdose death rate six times higher than in 1999 and a fatal third wave driven by synthetic fentanyl trafficking from China. Through the DEA's "360 Strategy" in Los Angeles, authorities are coordinating enforcement, diversion control, and youth outreach to combat transnational cartels and prosecute distributors of lethal mixtures. Simultaneously, clinical and policy leaders advocate for treating addiction as a chronic brain disease, promoting non-opioid pain management, and dismantling regulatory barriers to expand access to life-saving medications like naloxone.
- Y Combinator1h 1m
Advice on Organizing and Running Growth Teams from Dan Hockenmaier and Gustaf Alströmer
Dan Hockenmaier, Gustaf Alströmer, Craig Cannon, Toni, Michael Savage, Justin LaRosa, Mark Mandelbaum, Francesc Campoy, Dan Galpin, Dan Gallup
Dan Hockenmeyer of Basis One and Gustav Alströmer of Y Combinator discuss a growth strategy centered on prioritizing a single high-leverage channel and achieving product-market fit before scaling paid acquisition. They argue that early-stage teams must rely on analytical generalists who can model the entire business equation, using retention graphs to test high-impact hypotheses rather than chasing superficial metric tweaks. The discussion highlights critical lessons from Airbnb and Thumbtack, emphasizing that sustainable expansion requires building growth functions in-house, treating referrals as paid marketing with strict ROI calculations, and avoiding structural distractions like premature VP hires or reliance on saturated ad platforms.
- Milken Institute1h 1m
Institutional Investors: Managing for the Long Term
Christopher Ailman, Jerry Albright, Jingdong Hua, Kim Lew, Amy McGarrity, Hiromichi Mizuno, Chris Ailman
Five CIOs managing over $1.6 trillion across diverse institutional structures, from Carnegie's $3.5 billion foundation to Japan's $1.6 trillion GPIF, convened to analyze how unique liability profiles and time horizons dictate long-term investment strategies. The panelists detailed operational shifts toward sustainable "universal ownership," highlighted the World Bank's leadership in green bond markets, and emphasized the critical need to align staff incentives and board education with multi-decade fiduciary duties rather than short-term volatility. Despite diverging views on the necessity of formal ESG mandates and the degree of market influence asset owners should wield, the group collectively identified global development gaps and market structure fragilities as paramount risks requiring coordinated action.
- The Economist7 min
Who will challenge Donald Trump in 2020?
The 2020 Democratic primary acts as a decisive ideological referendum that will narrow a large field to a nominee by September. Vice President Joe Biden leads as the moderate frontrunner focused on electability, while Senator Bernie Sanders and Senator Elizabeth Warren compete for progressive voters with distinct policy platforms. Secondary contenders including Mayor Pete Buttigieg, Senator Kamala Harris, Senator Amy Klobuchar, and Senator Cory Booker seek to capitalize on the race's central tension between generational change and broad electoral appeal.
- Milken Institute1h 2m
Outsmarting Superbugs: What Are the Alternatives?
Margaret Hamburg, Matthew Hepburn, Peter Jackson, Nancy Knight, Jeanette Mucha, Peter Piot, Peggy Hamburg, David Wallace, Lance Price
Global leaders and organizations including the WHO, CDC, and the U.K. government are coordinating a multi-faceted response to antimicrobial resistance, which threatens to cause 10 million annual deaths by 2050 and mimic the 2008 financial crisis through massive economic losses. Innovative initiatives such as the CDC's AMR Challenge, Carb-X's $80 million funding for 40 development projects, and the U.K.'s "pull incentive" trial aim to revitalize the antibiotic pipeline by supporting SMEs and rewarding disease prevention rather than sales volume. Despite these advances, experts warn that rigid intellectual property laws, inadequate wastewater treatment, and capital gaps in microbiome startups hinder the deployment of new therapies needed to combat untreatable superbugs like drug-resistant tuberculosis.
- a16z30 min
Founding Stories: Anchorage
Chris Dixon, Diogo Monica, Nathan McCauley, Katie Haun
Founders Nathan and Diogo, previously instrumental in scaling security at Square and Docker, established Anchorage Digital to address the operational limitations of traditional cold storage for institutional crypto assets. The firm deploys a crash-resistant custody architecture that enables active on-chain participation, including staking and governance voting, while simultaneously serving as a founding node operator for the independent Libra Association in Geneva. This dual strategy aims to legitimize the broader cryptocurrency ecosystem by combining regulated fiduciary safeguards with a decentralized blockchain designed for global scalability and mass adoption.
- a16z22 min
The Economics of Term Sheets
This presentation dissects economic term sheet mechanics using hypothetical venture firms Haiku and Indigo to illustrate how varying liquidation preferences and option pools directly impact founder ownership. By contrasting Haiku's participating 1x preference with Indigo's non-participating structure, the analysis demonstrates that while Indigo offers less immediate dilution, Haiku's smaller capital injection and option pool size yield a different risk-reward profile for the founding team. The session concludes by framing the choice between these competing $2 million versus $4 million offers as a strategic calculation of runway extension versus long-term upside, pending a future discussion on governance rights.
- The Economist6 min
Secrets of the deep ocean
Scientists aboard the Australian Government's RV *Investigator* are surveying unexplored Tasmanian seamounts to assess deep-sea ecosystems at depths exceeding 1,000 meters. While Marine Protected Areas established in the 1990s show positive signs of recovery with returning urchin populations and anemones, the data reveals that the foundational stony coral matrix damaged by bottom trawling has not reformable over the past two decades. These findings will guide future conservation policies and promote sustainable fishing practices by highlighting the long-term resilience limits of these unique habitats.
- Milken Institute1h 22m
Toward a Healthier Future
Will Durant, Mike Milken, Tanisha Carino, Michael Milken, Francis Collins, Susan Desmond-Hellmann, Bernard J. Tyson, Seema Verma, Sue Desmond-Hellman
Representatives from the Gates Foundation, Kaiser Permanente, CMS, and NIH converged to outline a unified strategy shifting global health systems from reactive treatment toward proactive prevention and precision medicine. Leaders highlighted specific breakthroughs in gene therapy, AI-driven neural decoding, and data interoperability while proposing structural reforms to align financial incentives with long-term population wellness and disease eradication. The consensus among these major institutions emphasizes that future economic prosperity and reduced healthcare costs depend on integrating community infrastructure, digital infrastructure, and innovative financing models to address challenges ranging from mental health crises to rare genetic disorders.
- Y Combinator42 min
Jeremy Rossmann of Make School on Income Share Agreements and the Future of College
Jeremy Rossmann, Craig Cannon, William Triska, Vikram Malhotra, Evan Ward
MakeSchool, an accredited San Francisco institution founded by Rossman, delivers an accelerated two-year Bachelor of Science in Applied Computer Science through a project-based curriculum featuring live mentorship and an income share agreement that eliminates upfront tuition. This model targets lower-to-mid-income students by combining technical training with liberal arts skills to secure placements at major tech firms like Google and Tesla, contrasting with traditional four-year degrees and self-directed learning. By operating under new outcome-based regulations and validating its approach with five years of operational data, the school aims to reshape higher education incentives and prepare graduates for a future of lifelong learning.
- Milken Institute1h 2m
Envisioning the Future of Media and Entertainment
Julia Boorstin, Jeffrey Hirsch, Gale Anne Hurd, Charles D. King, Asif Satchu, Jeremy Zimmer, Jeff Hirsch
Industry leaders project a fragmented streaming landscape where major consolidators like Netflix and Disney+ coexist with premium add-on services, driven by a shift in creator leverage toward aggressive upfront deals over traditional backend participation. While writers face income compression due to shortened production cycles and structural residual gaps, the market is simultaneously evolving toward data-driven meritocracy that could reinstitute performance-based royalties. This evolution extends globally, with content featuring underrepresented demographics and non-U.S. productions becoming central to international revenue growth alongside a compressed theatrical window strategy.
- a16z21 min
How to Get the Most from Your Board
This presentation analyzes the critical dynamics of long-term venture capital relationships, emphasizing the need for entrepreneurs to align with board members who serve as strategic stewards rather than mere financial backers. It details how diverging economic interests and fiduciary duties influence three distinct exit scenarios: distress management through recapitalization, acquisition negotiations involving management carve-outs, and IPO processes where pricing conflicts arise. Ultimately, the discussion advises founders to rigorously assess investor incentives and liquidation structures to maintain alignment and build durable, independent public companies.
- a16z27 min
How to Understand and Choose a Venture Investor
David Swenson's endowment model and subsequent regulatory shifts enabled institutional investors to allocate significant capital to venture capital as a means of generating uncorrelated, power-law distributed returns. The industry now operates on structures requiring massive "home run" exits to offset frequent failures, while firms increasingly compete by providing operational expertise rather than just financial access. Looking forward, the sector faces intensified competition and a blurring of lines between private and public markets as companies stay private longer and secondary trading expands.