Latest Interviews
Showing 31–45 of 213 transcripts.
Clear all filters- All-In Podcast1h 30m
Supercharging a New FDA: Marty Makary on Science, Power & Patients
Marty Makary, Friedberg, Chamath, Jason, Dave
FDA Commissioner Marty McCary has implemented 42 major reforms within his first 10 months to accelerate drug approvals, reduce clinical trial timelines, and restore public trust by ending paternalistic mandates. The agency is reshaping its workforce, shifting research priorities toward environmental and microbiome factors, and challenging China's biotech dominance by streamlining U.S. regulatory infrastructure and adopting AI-driven decision tools. These aggressive changes include converting pivotal trial requirements, eliminating unnecessary animal studies, and reforming food and vaccine policies to lower costs and address chronic disease roots.
- All-In Podcast1h 31m
All-In's 2026 Predictions
Chamath, Jason Calacanis, David Friedberg, David Sacks
A group of prominent tech investors and founders, including David Sacks, Jason Calacanis, Chamath Palihapiti, and David Friedberg, discussed their 2026 economic, political, and business forecasts following Sacks' relocation to Austin amid concerns over California's proposed wealth tax. The panel projects a 4.5% to 6% U.S. GDP growth driven by the "Trump Boom" and productivity surges while predicting significant market disruptions such as the collapse of traditional SaaS models and a surge in IPOs for private giants like SpaceX and Stripe. Additionally, the conversation addressed emerging trends in deal-making and media, with participants anticipating a shift toward IP licensing agreements, the rise of citizen journalism, and potential geopolitical resolutions in Ukraine and Iran.
- All-In Podcast1h 27m
Howard Lutnick: How America Can Hit 6% GDP Growth in 2026
The Commerce Department, led by Howard Lutnick, is executing a comprehensive strategy to eliminate the national trade deficit by replacing universal tariffs with a "staircase" negotiation model that extracts massive foreign investment, such as Japan's $550 billion commitment to US infrastructure. This approach simultaneously integrates aggressive pharmaceutical pricing reforms and a high-barrier immigration program to curb welfare dependency while restructuring the CHIPS Act to prioritize national security and equity stakes in major domestic firms. The administration projects this shift will drive 4% to 6% annual GDP growth by prioritizing vocational labor and eradicating federal fraud, creating a revenue cycle designed to reduce the $26 trillion deficit.
- All-In Podcast1h 18m
All-In x Kill Tony: A Hilarious Holiday Special
Tony Hinchcliffe, Chamath, Friedberg, Jason Calacanis, David Sacks
The All-In Podcast team hosted its second annual holiday party in San Francisco, featuring comedian Tony Hinchcliffe to fill the void of Chamath Palihapitiya while Jason Calacanis, David Sacks, and David Friedberg delivered personal roasts. During the event, the hosts presented their annual "Bestie Awards" to identify major business winners like NVIDIA and Alphabet alongside political and scientific winners such as the crypto industry and asteroid nucleic acid discoveries. The gathering also served as a platform to discuss free speech trends, comedy industry shifts, and future technological breakthroughs while mocking specific political and social figures.
- All-In Podcast57 min
Scott Bessent: Fixing the Fed, Tariffs for National Security, Solving Affordability in 2026
Scott Bessent, Chamath, Jason, Friedberg, David
Secretary Bessent outlines a fiscal strategy projecting a 2025 deficit contraction to the mid-5% of GDP range, aiming to reach a 3% target by the end of the Trump presidency through a shift from revenue-focused tariffs to national security leverage. The administration attributes current affordability challenges to historical price levels rather than present inflation, while criticizing the Federal Reserve's quantitative easing policies as drivers of inequality that necessitate a balance sheet reduction and return to traditional rate-setting. Future growth is anticipated to follow the July completion of tax cuts and the launch of "Trump Accounts," a universal child savings initiative designed to expand equity ownership and stimulate a CapEx-led employment boom in 2026.
- All-In Podcast1h 30m
Bernie Sanders Says Stop All AI, China's Breakthrough, Inflation Down, Golden Age in 2026?
Bernie Sanders, Chamath, Jason, Friedberg, David Sacks
Bernie Sanders' proposal for a federal moratorium on AI data centers faced sharp criticism from hosts and industry figures who argued it would cede technological leadership to China while contradicting Sanders' traditional states' rights positions. Contrasting these concerns, experts like David Sacks and Chamath Palihapitiya emphasized the national security imperative of unimpeded AI growth and urged the industry to adopt philanthropic strategies to bridge the gap between technological profits and public benefit. Simultaneously, the discussion highlighted macroeconomic resilience with AI driving wage growth and GDP potential, even as public sentiment remains skeptical due to inflation and political disconnects.
- All-In Podcast1h 39m
Tucker Carlson: Rise of Nick Fuentes, Paramount vs Netflix, Anti-AI Sentiment, Hottest Takes
Tucker Carlson, Nick Fuentes, Charlie Kirk, Chamath, Jason, Friedberg
Paramount's $108 billion hostile takeover bid for Warner Bros. Discovery, backed by the Ellison family's equity and Middle Eastern funds, currently holds a slight edge over Netflix's rejected $83 billion offer in betting markets, though the WBD board has already publicly accepted the lower streaming-focused proposal. Concurrently, the discussion expands to geopolitical strategies involving Nick Fuentes' rise as a shock jock fueled by bot networks, the economic risks and infrastructure needs of AI adoption, and Tucker Carlson's critiques of NATO and recent US foreign policy actions. Industry leaders debate whether antitrust regulators can effectively handle these massive consolidations while analyzing the societal implications of identity politics and the potential for government overreach in a rapidly digitizing world.
- All-In Podcast1h 0m
Live Poker Match!: The Besties Vs. Phil Hellmuth, Alan Keating, and Jason Koon
Phil Hellmuth, Alan Keating, Jason Koon, Chamath, Friedberg, Molly Bloom
Hosted at The Venetian in Las Vegas, the inaugural "All-In Bestie Invitational Tournament" featured high-stakes professionals Chamath Palihapitiya, Jason Kuhn, and Phil Hellmuth competing in a chaotic, five-minute turbo format. Alan Keating dominated the rapid blind structures to eliminate Hellmuth first and secure victory in the high-variance event. The gathering also served as a catalyst for industry reform discussions, with participants advocating for experience-based poker models and honoring legends like Stu Ungar while socializing with guests such as Molly Bloom.
- All-In Podcast38 min
Molly's Game Uncensored: Mob Threats, FBI Raid & 100M Pots... And Still Won
Molly Bloom, Jason, Friedberg, Chamath, Lisa
Molly Bloom operated one of the world's most exclusive high-stakes poker rings in Los Angeles and New York from 2008 to 2013, generating up to $10 million in visible cash before federal authorities dismantled the operation due to her ties to Russian mob interests and her illegal rake. Despite surviving an armed home invasion and having nearly ten million dollars seized by the Division of Asset Forfeiture, Bloom declined a deferred prosecution deal to remain silent on her wealthy clientele and instead served a sentence of time served and probation. She subsequently published the best-selling book *Molly's Game*, which was adapted into a major film, and has since paid off her fines to reestablish herself as a speaker focused on leadership and effective presence.
- All-In Podcast1h 2m
Epstein Files Fallout, Nvidia Risks, Burry's Bad Bet, Google's Breakthrough, Tether's Boom
Burry, Friedberg, Alan Keating, Chamath, David, Phil Hellmuth, Jason Kuhn, Matthew
A near-unanimous congressional vote has triggered the release of Jeffrey Epstein's files, prompting speculation regarding intelligence ties and financial anomalies while prompting a detailed examination of Tether's massive US Treasury holdings and NVIDIA's record-breaking financials amidst emerging accounting disputes. The discussion further explores David Friedberg's strategic pivot from venture capital to operating a breakout company, alongside a profile of high-stakes poker champion Alan Keating, whose psychological mastery and chaos-based decision-making strategies outperform algorithmic solvers in live games. Collectively, these segments analyze significant developments in government transparency, cryptocurrency stability, semiconductor market dynamics, and the nuanced psychology of professional gambling under extreme pressure.
- All-In Podcast13 min
How Chamath Optimized His Health
Chamath, Ron, Dr. Carlsberg, Dr. London, Sean
Motivated by personal tragedies and a desire to optimize a finite lifespan, the speaker utilized advanced medical imaging and genetic analysis to reframe a decade of statin usage as a necessary preventative measure against atherosclerosis. While cardiac calcium scores indicate a near-zero short-term heart attack risk, detailed scans revealed a significant rise in non-calcified plaque and notable muscle loss, prompting a strategic focus on physical conditioning and continued monitoring. Complementing this personal health journey, the speaker addressed corporate leadership challenges at Shopify and the 80/90 office, emphasizing the critical role of in-person alignment in minimizing strategic drift and maintaining purpose within ambitious ventures.
- All-In Podcast55 min
Home Affordability Crisis, Palantir's Advantage, Big Short on AI, H-1B Abuse, Solar Storm Hits Earth
Michael Burry, Chamath, Jason, Friedberg, Trump, Omapproach, Latestinspace, David Sacks
Michael Burry disclosed a $9 million short position against Palantir and alleged accounting fraud by hyperscalers like Meta and Oracle, though hosts refuted his depreciation claims and criticized his broader short-selling tactics as fear-mongering. The discussion also examined California's rent control policies and Texas's housing affordability, contrasting government-driven credit expansion with market-based solutions, while analyzing proposed H-1B visa reforms and the economic drivers behind the migration of tech professionals to international hubs like Riyadh and Malaysia. Finally, the hosts reviewed the risks posed by recent G5 geomagnetic storms, noting potential grid disruptions and the emerging shift toward photon-based computing to mitigate future solar interference.
- All-In Podcast27 min
AI, Attention, and Ownership: Ari Emanuel Explains the Next Era of Entertainment
Ari Emanuel, Michael Ovitz, Elon Musk, Chamath, Jason, Friedberg
Following the 2019 restructuring of Endeavor into TKO Group Holdings, Ari Emanuel has pivoted the organization from traditional representation to owning high-value sports assets like the UFC and WWE while launching a standalone live events division to capitalize on the scarcity of human connection in the AI era. Emanuel predicts that the content landscape will shift toward creator-owned equity and syndication models, driving demand for global expansion in markets like China and Brazil alongside a compressed workweek that fuels entertainment consumption. With the company now prioritizing operational efficiency over public market valuation, this strategy aims to leverage platform neutrality and cross-border distribution to generate sustainable growth independent of traditional studio or team acquisitions.
- All-In Podcast26 min
Triple H on How WWE Evolved: Trump, The Rock, and the Rise of the Antihero
Triple H, Trump, The Rock, Paul "Triple H" Levesque, Jason, David, Chamath, Friedberg
WWE Chief Creative Officer Triple H outlines a strategic pivot where storytelling and charisma drive a business model that rivals the Marvel Cinematic Universe, securing major streaming partnerships with Netflix and ESPN while prioritizing live stadium attendance. The organization has diversified its talent acquisition to include college athletes and leverages the entertainment value of its performers to draw a family-friendly demographic that is 40% female. This approach integrates robust medical screening and a "partnership" creative process to sustain performer health while navigating geopolitical sensitivities and evolving character archetypes for a global audience.
- All-In Podcast1h 34m
Elon Musk: OpenAI Betrayal, His Future at Tesla, and the Next Big Thing — Grokipedia
Elon Musk, Sydney Sweeney, Bill Gates, Chamath, Friedberg, Jason Calacanis
Host David Sacks and his team launched "Disgracia Corner" to critique virtue signaling while detailing X's transition from fragile legacy heuristics to an AI-driven Grok algorithm capable of processing 100 million daily posts. The episode further chronicles the platform's three-year post-acquisition turnaround, which eliminated massive operational waste and reinstated banned accounts despite regulatory friction, alongside strategic updates on Tesla's corporate governance, FSD deployment, and a re-evaluation of climate solutions emphasizing solar dominance over fusion.