Latest Interviews
Showing 31–45 of 456 transcripts.
Clear all filters- Goldman Sachs19 min
Will AI Make Markets Less Efficient?
Osman Ali, Alison Nathan, George Lee
Goldman Sachs' Global Co-Head of Quantitative Investment Strategies, Osman Ali, discusses how his team leverages AI and machine learning to analyze market sentiment across 15,000 stocks daily, capturing the fact that over half of recent equity returns are now driven by themes rather than fundamentals. Ali explains that while advanced language models enhance market efficiency, their widespread adoption creates new alpha opportunities through crowding effects and predictable herd behavior, which the firm actively models to exploit. This strategy relies on a hybrid approach combining proprietary data, custom technology, and human experience to navigate a zero-sum game where increasing market complexity continuously generates fresh sources of value.
- Goldman Sachs15 min
Riding the AI Wave
The April 30 FOMC meeting revealed a divided Federal Reserve committee that shifted from expectations of a near-term rate cut to a non-committal stance, a position reinforced by the incoming appointment of hawkish member Kevin Warsh. While private sector leverage has decreased since the Great Financial Crisis, concerns regarding public sector debt sustainability and elevated term premiums persist alongside a robust equity rally driven by hyperscalers and artificial intelligence. Investment strategists consequently maintain a bullish but cautious 7/10 allocation to technology, avoiding fixed income while rotating into energy and defense to hedge against potential consumer drawdowns expected in the mid-year "air pocket."
- Stanford Online1h 6m
Stanford CS153 Frontier Systems | Anjney Midha from AMP PBC on Frontier Systems
Instructor Anj Pransanjane guides a cohort of roughly 500 in-person and thousands of remote students through a course framing the current AI era as a "great transition" driven by $1.2 trillion in projected compute investments. The curriculum details shifting industry bottlenecks, such as the rising costs of H100 GPUs and the strategic importance of verifiable context, while urging participants to build asymmetric advantages in non-scalable personal niches. Ultimately, the program challenges students to identify the necessary standards and institutions to transform compute from a monopolized resource into a standardized commodity.
- Goldman Sachs17 min
How Warsh Could Shape Fed Policy
Kevin Warsh, Rob Kaplan, Alison Nathan
Following the Justice Department's decision to drop its investigation of Jerome Powell, the Trump administration expects Kevin Warsh to be confirmed as the next Fed Chair by June. Warsh, a former "lieutenant" to Ben Bernanke who views quantitative easing strictly as an emergency tool, plans to collaborate with Treasury Secretary Bessent to manage the balance sheet while prioritizing a reduction in the Federal Reserve's communication burden through the potential elimination of the dot plot. This strategy aims to navigate sticky inflation and geopolitical uncertainties that have pushed market rate cut expectations into 2027, requiring Warsh to build consensus among diverse FOMC members to secure seven votes for any policy shift.
- Goldman Sachs41 min
Apollo's Jim Zelter on the Future of Private Credit
Apollo Global Management, led by Jim Zelter, is strategically expanding its $970 billion asset base to finance a projected $5 trillion to $6 trillion capital expenditure surge driven by AI infrastructure and industrial reshoring. By leveraging its integrated insurance subsidiary Athene and $150 billion in recent investment-grade capital, the firm aims to dominate the $40 trillion private credit market with a focus on large-scale projects like the Intel semiconductor venture and Japanese corporate carve-outs. This approach seeks to capitalize on the shift from non-investment grade lending to massive investment-grade financing needs while maintaining disciplined risk management that prioritizes fundamental value over market noise.
- Y Combinator21 min
BillionToOne Is Solving One of Biotech’s Hardest Problems
Jared Friedman, David Tsao, Oguzhan Atay
Billion to One, founded by PhD students Oguzhan and David, leverages proprietary synthetic DNA methods to detect rare cell-free DNA variations for prenatal screening and cancer liquid biopsies. Since its public listing with a valuation over $4 billion, the company has scaled its automated facility to process 600,000 tests annually and launched North Star Select for late-stage cancer treatment guidance. The firm now executes a strategic roadmap to address early-stage cancers through a capital-efficient progression from commercial adoption to population-wide screening, aiming to significantly reduce cancer mortality rates.
- The Economist9 min
Peptides are not a miracle drug | The Economist
Natasha Loder, Tim Cross, Jason Palmer
Driven by high-profile endorsements and internet culture, the unregulated global market for peptides bypasses clinical trials to offer performance-enhancing substances riddled with purity risks and unknown long-term health effects. Regulatory bodies in the United States and United Kingdom are attempting to address this crisis through compounding pharmacy oversight and vendor crackdowns, yet enforcement struggles against the speed of online sales and social media promotion. Experts warn that without rigorous scientific validation, the current environment prioritizes profit and self-experimentation over the biological safety required to distinguish beneficial compounds from dangerous contaminants.
- Jane Street47 min
The Cost of Concurrency Coordination with Jon Gjengset
Jon Gjengset, John, Gabriel Kreiman
The presentation challenges the conventional view that mutexes are inherently slow, demonstrating instead that performance degradation in high-concurrency environments stems from CPU cache coherence overheads and MESI protocol costs rather than the lock mechanism itself. To address false sharing and serialization issues found in reader-writer locks, the speaker details the Left-Right data structure, a lock-free architecture that achieves linear scaling for read-heavy workloads by decoupling reader access from writer synchronization. Finally, the discussion emphasizes that optimal synchronization strategy depends on the specific read-to-write ratio and consistency requirements, urging developers to profile cache behavior and avoid blind optimization of lock primitives.
- a16z47 min
The New Media Playbook with Marc Andreessen & Ben Horowitz
Marc Andreessen, Ben Horowitz, Erik Torenberg
The firm fundamentally redefines media strategy by replacing the defensive posture of traditional journalism with an offense-oriented approach that prioritizes speed, founder-led personal branding, and content saturation to control narratives within a 24-hour cycle. By treating viral posts as the primary medium and leveraging an OODA loop of rapid observation and action, the organization enables portfolio companies to generate immediate engagement through direct CEO communication rather than abstract corporate messaging. This ecosystem now functions as a comprehensive launch service and talent development pipeline, positioning the firm as the definitive standard for "New Media" roles while advising leaders to embrace controversy as a necessary signal of power in a landscape where old media acts only as a lagging indicator.
- Goldman Sachs8 min
New Worries
Josh Schiffrin, Chris Hussey, Josh Shiprin
Goldman Sachs Chief Strategy Officer Josh Shiprin highlighted that geopolitical instability and surging oil prices have overshadowed recent payrolls data, creating a complex stagflationary environment that complicates the Federal Reserve's outlook. While maintaining confidence in an impending rate cut, Shiprin warned that the duration of the conflict could alter the timing of reductions and urged investors to adopt a long-term strategy focused on a steepening U.S. 2s10s yield curve amidst heightened market uncertainty.
- Goldman Sachs16 min
The New AI Trades
In early 2026, software stocks suffered a 25% valuation collapse as forward earnings multiples compressed, while investors grappled with AI-driven disruption risks across sectors like legal and media. Simultaneously, five U.S. hyperscalers are projected to spend $660 billion on capital expenditures this year, a surge consuming 90% of their operating cash flows that has forced reduced buybacks and increased debt reliance. Amidst these headwinds, Goldman Sachs forecasts an S&P 500 recovery driven primarily by 12% fourth-quarter earnings growth and a market rotation toward cyclical sectors rather than AI-centric leaders.
- Milken Institute51 min
Innovation in Artificial Intelligence and Manufacturing | Middle East & Africa Summit 2025
Hunny Bhagchandani, Kaushik Burman, Frans Cronje, Songo Didiza, Guy Diedrich, Mostafa El-Ghorab, Kweilin Ellingrud, John Kamara, Francis Kariuki, Ayaan Mohamed, Editha Mshiu, Emily Musil, Nneile Nkholise, Derick Nwumfor Chunga, Michael Milken
Launched in 2021, the Milken-Mozzeppe Innovation Prize's fourth "AI and Manufacturing" track selected ten semi-finalists from over 12,000 global applicants to compete for a $1 million grand prize at the May 2026 Milken Institute Global Conference. A panel of industry experts evaluated these contenders based on commercial viability and technological depth, with five companies including Digitech Oasis and Blee Glee Management Company advancing to the final round while all ten recipients received $50,000 seed awards. Strategic commentary from leaders such as Michael Milken underscored the program's role in catalyzing local African manufacturing, creating youth jobs, and disintermediating global industries through AI-driven innovation.
- Goldman Sachs26 min
Goldman Sachs Exchanges: Outlook 2026 | Episode 1: The Big Picture
Jan Hatzius, Dominic Wilson, Alison Nathan
Goldman Sachs projects 2026 global growth to reach 2.7%, driven by the "One Big Beautiful Bill Act," German fiscal easing, and the fading impact of 2025 tariffs. The firm forecasts a 2.5% expansion for the U.S. economy alongside expected Federal Reserve rate cuts that aim to lower inflation and address labor market stagnation. While equities are anticipated to deliver low double-digit returns, analysts warn of recession risks tied to the "SOM Rule" and elevated valuations that may trigger significant market volatility.
- The Economist9 min
Why Israel is closely watching the Iran protests
Anshel Pfeffer, Jason Palmer, Eva
Following a twelve-day war in June, intensified protests and economic instability in Iran threaten to shatter the regime's hold on power while prompting leadership concerns over potential external retaliation to divert attention. In response, Israeli Prime Minister Benjamin Netanyahu is maintaining a low-profile strategy of strategic patience, allowing internal Iranian dynamics to unfold rather than launching immediate military strikes. This approach aims to facilitate long-term geopolitical shifts, including the eventual erosion of Iran's proxy network and the potential for a future strategic alliance that could end decades of hostility.
- a16z12 min
AI Is Coming For These 3 Industries In 2026 (a16z Big Ideas)
Ryan McEntush, Angela Strange, Sarah Wang
Ryan McIntosh, Angela Strange, and Sarah Wang identify three pivotal 2026 inflection points defining the future of American industry, finance, and software architecture. These experts forecast a transition where the U.S. must vertically integrate its electro-industrial ecosystem to match China, financial institutions must abandon legacy mainframes for AI-native data systems to unlock tenfold operational scaling, and dynamic AI agent layers must displace traditional systems of record to enable autonomous execution. Collectively, these shifts emphasize that future economic and military power depends on controlling embodied electrified components, unifying data across unstructured sources, and achieving product velocity through continuous AI-driven iteration.