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  1. 20VC with Harry Stebbings1h 28m

    Anthropic Raises $45B but Falls Short on Compute & Thoma Bravo Hand Back Medallia Keys to Creditors

    Jason Lemkin, Rory O'Driscoll, Harry Stebbings

    The event analyzes a pivotal shift in the AI landscape where market competition is evolving from human-led selection to autonomous AI-agent vendor choices, creating a three-way oligopoly among OpenAI, Anthropic, and Google. Strategic dynamics are further complicated by regulatory friction, such as China blocking Meta's acquisition of Manus, and severe private equity distress driven by the obsolescence of legacy enterprise software. Investors are responding by consolidating venture capital portfolios around massive, infrastructure-focused bets like NVIDIA while liquidating human-centric tools like Figma and Duolingo that face existential risk from agent-driven workflows.

  2. Sourcery with Molly O'Shea33 min

    The $10 Trillion Bet on Humanoid Robots | Figure Founder Brett Adcock

    Brett Adcock, Molly O'Shea

    Founded by Archer eVTOL creator Brett Adcock, Figure AI pursues the commercialization of general-purpose humanoid robots capable of operating autonomously for extended shifts across diverse industries. Having raised nearly $2 billion with a $39 billion valuation, the company recently terminated an OpenAI partnership to maintain control over its vertically integrated hardware and AI stack, aiming to triple production by May and deploy thousands of units within the year. Despite facing technical hurdles in scaling reliability, Figure projects a market opportunity worth trillions as it transitions from prototype testing to mass commercial deployment in homes and factories.

  3. The Diary Of A CEO1h 41m

    Stock Expert: Becoming Rich Is Simple, But You Won’t Do It!

    Ben Felix

    PWL Capital's Ben Felix leverages decades of academic research to challenge conventional financial wisdom, arguing that long-term success relies more on behavioral discipline than technical expertise. The presentation outlines a strategy prioritizing low-cost global equity exposure while identifying ten critical mistakes, ranging from undervaluing human capital to the hidden costs of homeownership and the inefficiencies of market timing. By applying frameworks like the PERMA model to goal setting and advocating for 100% equity allocation, the session provides a comprehensive roadmap for navigating retirement planning, AI-driven economic shifts, and inevitable market volatility without emotional interference.

  4. Sequoia Capital27 min

    Demis Hassabis: We're Three Quarters of the Way to AGI

    Demis Hassabis, Konstantine Buhler, Dennis

    Demis Hassabis founded DeepMind with the strategic intent of leveraging game development revenue to fund the pursuit of artificial general intelligence, a goal he predicts will be realized by 2030. Following a pivotal breakthrough with AlphaFold that solved the protein folding problem, the organization expanded into Isomorphic Labs to accelerate drug discovery and is now pioneering the application of AI for scientific simulation in fields like biology and economics. Hassabis maintains that classical neural networks are sufficient to model complex biological systems and views information as the fundamental building block of the universe, positioning AI as the ultimate tool for understanding reality.

  5. Y Combinator41 min

    Demis Hassabis: Agents, AGI & The Next Big Scientific Breakthrough

    Demis Hassabis, Garry Tan

    DeepMind CEO Demis Hassabis projects Artificial General Intelligence will emerge around 2030, contingent on inventing specific architectural breakthroughs in continual learning and structured memory rather than merely scaling current methods. While deep tech startups are warned to anticipate AGI disrupting their decade-long cycles, the organization is simultaneously deploying efficient, modular "Flash" and open-source nano models to power edge devices and accelerate scientific discovery in fields like drug design and materials science. Ultimately, DeepMind advocates for interdisciplinary collaboration between AI and physical sciences to overcome current reasoning limitations and drive the next generation of autonomous agents.

  6. Sourcery with Molly O'Shea1h 44m

    300 Pages on Anduril: Inside Modern Warfare

    Kyle Harrison, Molly O'Shea

    Anduril Industries disrupts the defense sector by replacing the Pentagon's cost-plus acquisition model with fixed-cost contracts and a "build-to-mission" strategy that prioritizes high-volume, low-cost autonomous systems. The company utilizes its proprietary Lattice AI platform to integrate multi-domain assets into a unified network, aiming to counter China's industrial superiority by accelerating the production of drones, torpedoes, and munitions. Founded on the philosophy that credible military capability is essential for conflict deterrence, Anduril has seen its valuation double to roughly $60 billion as global power dynamics shift toward Great Power competition.

  7. Milken Institute20 min

    A Conversation with IMF Managing Director Kristalina Georgieva | Global Conference 2025

    Kristalina Georgieva, Gerard Baker

    Following an IMF downgrade of the global growth forecast to 2.8%, Managing Director Kristalina Georgieva addresses diverging inflation trajectories and rising fiscal constraints while urging China to undertake structural reforms to shift toward domestic consumption and reduced state intervention. Amidst a volatile trade landscape marked by the erosion of fair trade mechanisms and a transition to new economic equilibriums, policymakers are prioritizing bilateral agreements and supply-side productivity enhancements to stabilize financial markets and foster sustainable expansion. This strategic pivot seeks to navigate "off the charts" uncertainty by balancing emerging market resilience against the severe deflationary pressures in China and the debt challenges facing advanced economies.

  8. a16z58 min

    Aaron Levie on AI Adoption and Enterprise Workflows | The a16z Show

    Aaron Levie, Steven Sinofsky, Martin Casado

    Organizations are pivoting from failed centralized AI mandates to integrating autonomous agents directly into legacy workflows, necessitating significant architectural shifts beyond traditional hybrid software models. While token-gaming and system integration bottlenecks currently stifle productivity gains, the resulting increase in infrastructure complexity and code volume is projected to drive sustained demand for engineering talent rather than reduce it. This transition requires years of organizational change management to modernize fragmented data environments, ultimately creating a multi-decade opportunity for system integrators to bridge the gap between probabilistic machine users and rigid enterprise security protocols.

  9. Goldman Sachs18 min

    Winning the Right to Invest: 20VC’s Harry Stebbings

    Harry Stebbings, Bobby Molavi

    Harry Cassell reframes media distribution as a critical weapon for securing investment rights, leveraging a data-driven content strategy that generated $6.1 million in 36 hours to differentiate his platform from traditional venture capital models. Critiquing the current market's saturation by large multi-stage funds, he emphasizes founder empathy, specific personality traits, and a robust LP network to navigate an environment where capital is commoditized and growth expectations have shifted. Looking toward Europe, Cassell predicts a decade of massive company creation driven by lower barriers to entry and increased founder resilience, citing early successes like Lovable as evidence of a reinvigorated ecosystem ready to compete globally.

  10. 20VC with Harry Stebbings1h 20m

    AppLovin CEO: Why Founders Shouldn't Angel Invest & Why the Best Don't Need Mentorship

    Adam Foroughi, Harry Stebbings

    In 2024, AppLovin CEO Adam Faroge received $83 million in compensation contingent on stock performance while executing a radical strategic pivot that slashed the workforce by 50% and eliminated C-level roles to prioritize AI-driven efficiency. This restructuring transformed the company into a lean operation with a 400-person engineering core generating $10 million in EBITDA per employee, enabling triple-digit revenue growth and an 84% EBITDA margin through aggressive share buybacks and a shift to performance-based advertising. Faroge's approach, which integrates AI into 80–90% of code production and merges product management with engineering, aims to secure a potential $1 trillion valuation driven by Connected TV expansion rather than traditional social networking models.

  11. The Diary Of A CEO2h 0m

    Sex Expert: What Women Actually Need To Enjoy Sex

    Dr Rena Malik

    Dr. Reena Malik outlines a comprehensive framework for sexual health that links declining intimacy among young adults to lifestyle factors like screen addiction, stress, and poor diet. The presentation details four pillars of optimization—nutrition, cardiovascular and pelvic floor exercise, environmental stress management, and anatomical knowledge—while emphasizing how erectile dysfunction often serves as an early warning for heart disease. By prioritizing these physiological and behavioral adjustments, individuals can improve longevity and combat the modern loneliness epidemic before considering medical interventions like testosterone replacement therapy.

  12. Y Combinator39 min

    Replit's CEO On The Only Two Jobs Left In The Company Of The Future

    Amjad Masad, Andrew Miklas

    Replit recently secured $400 million in Series D funding to achieve a $9 billion valuation while executing a strategic pivot toward "AI-native developers" who build software through natural language interactions with their Agent 4 system. By abstracting traditional coding behind multimodal AI agents, the platform enables non-engineers to rapidly deploy applications and reduce development costs by up to 70%, effectively shifting the company's focus from technical setup to high-level business orchestration. This product-led growth model empowers a diverse range of users, from solo entrepreneurs to enterprise teams, to accelerate idea velocity and build internal tools without requiring deep programming expertise or large engineering budgets.

  13. 20VC with Harry Stebbings49 min

    Replit CEO: Why the SaaS Apocalypse is Justified & Why Coding Models are Plateauing | Amjad Masad

    Amjad Masad, Harry Stebbings

    In March 2025, Replit CEO Amjad Massad declared a strategic pivot from traditional coding instruction to agentic creation, leveraging Opus 4.6 to embed autonomy directly into foundation models while maintaining a multi-provider architecture that balances Anthropic's session length with Google Gemini's cost efficiency. The company now targets enterprise operations to displace vertical SaaS through maintainable, self-correcting AI agents, prioritizing market dominance over immediate margin optimization despite significant infrastructure costs. This approach acknowledges the obsolescence of legacy IDEs while navigating regulatory hurdles, such as App Store delays, to capture value in an expanding total addressable market for automated software generation.

  14. All-In Podcast1h 31m

    SpaceX-Cursor Deal, SaaS Debt Bomb, New Apple CEO, SPLC Indictment, Colon Cancer Spike

    John Ternus, Tim Cook, David Sacks, David Freiberg

    David Sacks reported to the White House that President Trump is actively supporting AI development and private power generation, while SpaceX finalized a definitive agreement to acquire Cursor for up to $60 billion to leverage its GPU infrastructure against competitors. Simultaneously, the discussion highlighted severe distress in the SaaS sector driven by AI disruption and a major fraud indictment against the Southern Poverty Law Center involving hidden accounts and payments to hate groups. In health news, a Barcelona study identified the herbicide piclorum as a significant environmental trigger for a sharp rise in colorectal cancer among young adults, prompting calls for updated safety testing and regulation.

  15. Y Combinator10 min

    How To Build A Company With AI From The Ground Up

    Diana Hu

    This presentation argues that AI must function as a company's central operating system rather than a peripheral tool, driving a shift toward closed-loop systems that render the entire organization queryable for automated decision-making. In this model, traditional middle-management hierarchies are eliminated and replaced by AI agents that execute engineering tasks and manage workflows, allowing human leaders to focus on strategy as founders, builders, or directly responsible individuals. By leveraging these "AI software factories," startups gain a decisive advantage over incumbents to achieve tenfold velocity increases and operate with human headcount replaced by optimized token usage.