Latest Interviews
Showing 571–585 of 2,502 transcripts.
Clear all filters- Milken Institute36 min
Influence to Shape Platforms for Good | Asia Summit 2025
Ross Butler, Bhumi Pednekar, Curtis S. Chin
Actors Bhumi Pednekar and Ross Butler discuss their respective careers of dismantling stereotypes in Indian and Hollywood cinema while highlighting the societal pressures to pursue traditional professions over creative arts. Beyond entertainment, both advocates emphasize the transformative power of social media for disaster relief and mental health awareness, with Pednekar leading UNDP climate initiatives and Butler championing cross-cultural co-productions in Southeast Asia. Looking forward, the duo plans to collaborate on a project bridging Indian and Asian narratives while mentoring emerging talent to redefine regional storytelling globally.
- Goldman Sachs44 min
Memorial Sloan Kettering Cancer Center’s CEO on the Future of Cancer Treatment
Selwyn M. Vickers, Brian Robinson, Dr. Selwyn Vickers
Memorial Sloan Kettering leverages its vast biobank and dual expertise in computational oncology to drive a "golden era" of cancer treatment, where AI-driven predictive models and breakthroughs in immunotherapy have transformed survival rates for aggressive malignancies. Concurrently, the institution confronts rising youth cancer incidence and systemic health inequities by developing accessible genetic screening tools and deploying low-infrastructure immunotherapy protocols globally. These clinical and technological advances are grounded in a leadership philosophy that prioritizes professional excellence to dismantle socioeconomic barriers and improve care access for underserved populations.
- a16z56 min
Opendoor CEO: Building the Amazon for Homes
Kaz Nejatian, Alex Rampell, Erik Torenberg
CEO Kaz Nejatian is steering Opendoor away from its failed inventory-heavy iBuyer model toward a software marketplace aiming to control 10% of housing supply to disrupt traditional agent monopolies through 1% commissions. Following a strategic pivot triggered by the "triple whammy" of Zillow's competition, rising interest rates, and capital pullback, the company now operates in every U.S. market with features like Dallas' seven-day return window to build high-frequency demand. The ultimate vision is to internalize the entire real estate transaction chain by bundling financing and insurance, thereby reducing friction and delivering net value to consumers while avoiding the pitfalls of operating as a low-frequency asset-holding business.
- Y Combinator41 min
Ask These Questions Before Starting An AI Startup
Founder and alignment researcher Sam Altman warns that the imminent arrival of AGI within two to three years forces startups to radically rethink hiring, product design, and long-term strategy beyond traditional focus models. He argues that enterprises will soon bypass external SaaS providers by building internal software with AI, while consumer markets may shift from static apps to on-demand, AI-generated solutions that require new trust mechanisms like automated auditing. Ultimately, Altman urges founders to prioritize solving hard infrastructure problems and societal impact over immediate monetization, as the window to build defensible moats against commoditization and centralized control narrows rapidly.
- All-In Podcast12 min
The Next Bubble Is Already Here - Chamath Palihapitiya
Chamath Palihapitiya, Jason, Friedberg, Nick
Speakers warn that the private equity sector, having grown to $5 trillion through artificial borrowing, faces a structural collapse driven by mismanagement and stagnant distributions as capital migrates toward a new bubble in private credit. To address the dysfunction of traditional IPOs and flawed SPAC structures, the Raptor 2 initiative has secured backing from 98.7% of blue-chip institutional investors to introduce a transparent, performance-aligned model for high-growth companies. Future iterations, Raptor 3, propose a "pre-baked IPO" using pure common stock to eliminate conversion risk and ensure fair pricing for public shareholders.
- a16z1h 3m
The Lawyerly Society vs. The Engineering State: Who Owns the Future?
Dan Filgate frames the U.S.-China competition not as a race with a definitive winner, but as a complex synthesis where American strengths in wealth creation and intellectual property must balance against China's engineering-driven capacity for infrastructure and manufacturing. The analysis highlights critical frictions between the U.S. "lawyer culture," which often paralyzes industrial progress through legal hurdles, and China's ability to enforce large-scale goals despite systemic human rights concerns and IP vulnerabilities. Ultimately, the dialogue urges the United States to avoid complacency by adopting more functional industrial policies that prioritize physical production and logistical efficiency rather than rigid legalistic processes.
Joby, Dirac & Allen Control: The Future of Air, AI Factories & Defense Tech
Molly O'Shea, Eric Allison, Filip Aronshtein, Steve Simoni
The Reindustrialize 2024 summit in Detroit highlighted strategic capital infusions and operational expansions by key players such as Joby Aviation, Dirac, and Allen Control Systems to address critical gaps in the American industrial base. Joby Aviation secured further funding and strategic partnerships to advance its FAA-certified eVTOL air taxi program, while Dirac deployed AI-driven software to automate manufacturing instructions and preserve tribal knowledge, and Allen Control Systems raised capital to scale its "Bullfrog" kinetic defense turret for drone warfare. Collectively, these developments reflect a broader industry urgency to reverse offshoring trends, reintegrate vertically controlled supply chains, and deploy domestic manufacturing solutions amidst evolving geopolitical and technological pressures.
- The Economist11 min
Has Mars revealed a new clue about life on its surface?
Dr Katie Stack Morgan, Alok Jha
NASA's Perseverance rover recently identified distinct mineral patterns in Mars' "Chiava Falls" outcrop that the science team voted to classify as potential biosignatures, marking the closest any agency has come to detecting ancient life. While these findings strongly suggest a biological origin due to their specific chemical arrangement, the rover's limitations require the samples to be returned to Earth for definitive analysis. This critical next step relies on the Mars Sample Return program, which currently faces budgetary uncertainty even as scientists describe the discovery as a historic scientific milestone.
Vibe Coding, AI Valuations & the Supercycle | Navin Chaddha, Mayfield
The 2025 venture capital landscape is dominated by artificial intelligence, which absorbed 67% of global funding and created a 30.9% valuation premium for AI-native companies while leaving non-AI startups struggling to raise capital. Investors now prioritize founders with high emotional intelligence and proven execution over concepts, demanding consumption-based pricing models and "painkiller" solutions that deliver recurring revenue rather than relying on unsustainable hype. This shift is accelerating a projected $3 to $6 trillion automation opportunity in the knowledge worker sector, with market value migration moving from current infrastructure dominance toward applied AI and agentic technologies over the next decade.
- Milken Institute30 min
A Conversation with Saweetie: Harnessing Philanthropy to Build Financial Futures | Asia Summit 2025
Saweetie, Diamonté "Saweetie" Harper, Richard Lui
Multi-platinum rapper and entrepreneur Sweetie discusses her trajectory from baking cookies as a child to securing high-profile partnerships with brands like McDonald's and Calvin Klein while maintaining an authentic leadership style. She details the founding of the I See Baby Foundation, which aims to instill financial literacy in underrepresented youth by leveraging her personal financial lessons and her grandmother's advice. The conversation concludes with her strategic vision to build a decade-long infrastructure that teaches communities how to live educated, self-determined lives through a diverse, women-led team.
- a16z43 min
The Person Who Runs HR For 2 Million Federal Workers
Katherine Boyle, Scott Kupor, Greg Barbaccia
The administration is executing a sweeping overhaul of the federal workforce to secure national leadership in the AI race, projecting a reduction of 300,000 civilian employees while dismantling 43 years of hiring barriers to mandate technical skill testing. This strategy shifts performance evaluations toward a forced distribution model and replaces risk-averse culture with outcome-based efficiency, targeting a critical talent gap by recruiting early-career professionals and private sector executives for short-term secondments. Key initiatives include centralizing citizen data through a "One Government" portal, deploying generative AI tools like ChatGPT on government desktops, and restructuring contractor oversight to prevent cost sprawls driven by non-technical management.
- All-In Podcast54 min
Ro Khanna Calls Out Both Parties: Immigration, Tech & Free Speech
U.S. Representative Rohit "Roe" Khanna detailed his vision for immigration reform, border security, and economic patriotism during a fifth podcast appearance, advocating for skilled talent pathways while rejecting blanket visa fees and the zeroing out of asylum claims. The Representative criticized the Democratic Party for alienating the tech industry and emphasized the need for a forward-looking agenda focused on domestic revitalization, AI innovation, and bipartisan crime solutions rather than constant opposition to the Trump administration. Khanna also addressed immediate legislative crises, including the government shutdown caused by constitutional disputes over funding freezes, while reaffirming his commitment to banning congressional stock trading and warning against political violence fueled by an attention-driven media ecosystem.
- Milken Institute47 min
The State of Global Capital Markets and the Future of Finance | Asia Summit 2025
Richard Lui, David Chua, Michael Goosay, Hisham Hamdan, Noriko Honda Chen
A panel of investment experts analyzed the diverging returns between emerging and developed markets, highlighting Asia's undervalued status despite its dominance in global GDP and growth. The discussion identified a strategic shift toward a "third wave" centered on India and Japan, driven by regulatory reforms, demographic trends, and the need for active management to overcome state-owned enterprise inefficiencies. Participants concluded that navigating liquidity risks, deglobalization, and the AI boom requires skilled investors to capitalize on structural transitions while balancing commercial returns with evolving social mandates.
- All-In Podcast23 min
Rick Caruso on California’s Collapse: Broken Leadership, LA Wildfire Failures & the Fix
Rick Caruso, Karen Bass, Chamath, Jason
In the wake of the Palisades fires, developer Rick Caruso contrasts his private sector emergency preparations against the city's failures, blaming incompetent governance under Mayor Karen Bass for the destruction of 90% of the homes. Caruso argues that ideological politics have paralyzed local authorities, leading him to propose a competency-based administration that enforces zero tolerance for street encampments while simultaneously securing federal aid and infrastructure upgrades for rebuilding. As he evaluates potential political bids, Caruso emphasizes that California must prioritize practical solutions over political maneuvering to reverse systemic decay and restore the state's status as a national leader.
- All-In Podcast25 min
Arm CEO Rene Haas on AI: Nvidia Lessons, Intel’s Decline and the US-China Chip War
Rene Haas, Jensen Huang, David, Jason
Following a landmark September IPO that vaulted its valuation to $150 billion, Arm is leveraging its foundational IP to transition from a smartphone architecture provider into a strategic partner for Nvidia and a supplier for the emerging "Physical AI" robotics market. Chief Executive Officer Rene Haas is aggressively reshaping the company's global culture and engineering focus to accelerate speed-to-market, while explicitly navigating complex geopolitical frictions and supply chain constraints to maintain a unified global ecosystem. With its architecture underpinning critical advances in both data center training chips and energy-efficient endpoint inference, Arm is positioning itself to dominate a diverging semiconductor landscape where specialized hardware will define future AI capabilities.