Latest Interviews
Showing 676–690 of 6,340 interview transcripts.
- Dwarkesh Patel2h 14m
How GPT, Claude, and Gemini are actually trained and served – Reiner Pope
John Mueller Jr. discusses the technical and economic drivers behind AI inference architectures, detailing how startups like Maddox optimize for memory bandwidth bottlenecks and latency bounds in sparse Mixture of Experts models. The analysis highlights that frontier models are currently overtrained by a factor of 100x relative to scaling laws, a phenomenon that dictates current API pricing structures for context length and caching tiers. Finally, Mueller explains how industry scaling is shifting toward larger single-rack domains to maximize expert parallelism while utilizing reversible network techniques to mitigate training memory constraints.
- All-In Podcast1h 9m
CA Governor Candidate Steve Hilton on Why California is Destroying Itself & How a Republican Can Win
Steve Hilton, Chamath, Jason, Friedberg
Steve Hilton, a former UK government advisor and naturalized U.S. citizen, is leading the crowded California gubernatorial race by proposing a radical conservative platform focused on eliminating state income tax for households earning under $100,000 while slashing the state budget by $60 billion. His policy agenda identifies union power, CEQA litigation, and climate regulations as primary drivers of the housing and energy crises, advocating for immediate construction deregulation, increased oil production, and strict law enforcement to address homelessness and crime. With poll numbers ahead of Democratic contenders, Hilton aims to capitalize on a perceived Republican base in the state to implement these affordability measures in the 2026 election.
- Sequoia Capital27 min
Demis Hassabis: We're Three Quarters of the Way to AGI
Demis Hassabis, Konstantine Buhler, Dennis
Demis Hassabis founded DeepMind with the strategic intent of leveraging game development revenue to fund the pursuit of artificial general intelligence, a goal he predicts will be realized by 2030. Following a pivotal breakthrough with AlphaFold that solved the protein folding problem, the organization expanded into Isomorphic Labs to accelerate drug discovery and is now pioneering the application of AI for scientific simulation in fields like biology and economics. Hassabis maintains that classical neural networks are sufficient to model complex biological systems and views information as the fundamental building block of the universe, positioning AI as the ultimate tool for understanding reality.
- Y Combinator41 min
Demis Hassabis: Agents, AGI & The Next Big Scientific Breakthrough
DeepMind CEO Demis Hassabis projects Artificial General Intelligence will emerge around 2030, contingent on inventing specific architectural breakthroughs in continual learning and structured memory rather than merely scaling current methods. While deep tech startups are warned to anticipate AGI disrupting their decade-long cycles, the organization is simultaneously deploying efficient, modular "Flash" and open-source nano models to power edge devices and accelerate scientific discovery in fields like drug design and materials science. Ultimately, DeepMind advocates for interdisciplinary collaboration between AI and physical sciences to overcome current reasoning limitations and drive the next generation of autonomous agents.
300 Pages on Anduril: Inside Modern Warfare
Anduril Industries disrupts the defense sector by replacing the Pentagon's cost-plus acquisition model with fixed-cost contracts and a "build-to-mission" strategy that prioritizes high-volume, low-cost autonomous systems. The company utilizes its proprietary Lattice AI platform to integrate multi-domain assets into a unified network, aiming to counter China's industrial superiority by accelerating the production of drones, torpedoes, and munitions. Founded on the philosophy that credible military capability is essential for conflict deterrence, Anduril has seen its valuation double to roughly $60 billion as global power dynamics shift toward Great Power competition.
- Milken Institute20 min
A Conversation with IMF Managing Director Kristalina Georgieva | Global Conference 2025
Kristalina Georgieva, Gerard Baker
Following an IMF downgrade of the global growth forecast to 2.8%, Managing Director Kristalina Georgieva addresses diverging inflation trajectories and rising fiscal constraints while urging China to undertake structural reforms to shift toward domestic consumption and reduced state intervention. Amidst a volatile trade landscape marked by the erosion of fair trade mechanisms and a transition to new economic equilibriums, policymakers are prioritizing bilateral agreements and supply-side productivity enhancements to stabilize financial markets and foster sustainable expansion. This strategic pivot seeks to navigate "off the charts" uncertainty by balancing emerging market resilience against the severe deflationary pressures in China and the debt challenges facing advanced economies.
- Goldman Sachs17 min
How Warsh Could Shape Fed Policy
Kevin Warsh, Rob Kaplan, Alison Nathan
Following the Justice Department's decision to drop its investigation of Jerome Powell, the Trump administration expects Kevin Warsh to be confirmed as the next Fed Chair by June. Warsh, a former "lieutenant" to Ben Bernanke who views quantitative easing strictly as an emergency tool, plans to collaborate with Treasury Secretary Bessent to manage the balance sheet while prioritizing a reduction in the Federal Reserve's communication burden through the potential elimination of the dot plot. This strategy aims to navigate sticky inflation and geopolitical uncertainties that have pushed market rate cut expectations into 2027, requiring Warsh to build consensus among diverse FOMC members to secure seven votes for any policy shift.
- a16z58 min
Aaron Levie on AI Adoption and Enterprise Workflows | The a16z Show
Aaron Levie, Steven Sinofsky, Martin Casado
Organizations are pivoting from failed centralized AI mandates to integrating autonomous agents directly into legacy workflows, necessitating significant architectural shifts beyond traditional hybrid software models. While token-gaming and system integration bottlenecks currently stifle productivity gains, the resulting increase in infrastructure complexity and code volume is projected to drive sustained demand for engineering talent rather than reduce it. This transition requires years of organizational change management to modernize fragmented data environments, ultimately creating a multi-decade opportunity for system integrators to bridge the gap between probabilistic machine users and rigid enterprise security protocols.
- The Economist6 min
Why does political violence seem to be getting worse in America? | The Economist
During the White House Correspondents' Dinner, 31-year-old Cole Thomas Allen breached the Hilton Hotel security checkpoint to attempt an attack on President Trump before being tackled by police. The incident forced an immediate evacuation of the ballroom, resulted in an officer injury, and triggered a review of Secret Service protocols following the shooter's prior claims of lax access measures. While President Trump utilized the event to advocate for new defensive infrastructure and praised the agency's response, experts warn that despite a perceived rise in political violence, the long-term impact on governance and approval ratings will likely remain tied to broader economic conditions rather than the assault itself.
- Goldman Sachs18 min
Winning the Right to Invest: 20VC’s Harry Stebbings
Harry Cassell reframes media distribution as a critical weapon for securing investment rights, leveraging a data-driven content strategy that generated $6.1 million in 36 hours to differentiate his platform from traditional venture capital models. Critiquing the current market's saturation by large multi-stage funds, he emphasizes founder empathy, specific personality traits, and a robust LP network to navigate an environment where capital is commoditized and growth expectations have shifted. Looking toward Europe, Cassell predicts a decade of massive company creation driven by lower barriers to entry and increased founder resilience, citing early successes like Lovable as evidence of a reinvigorated ecosystem ready to compete globally.
AppLovin CEO: Why Founders Shouldn't Angel Invest & Why the Best Don't Need Mentorship
Adam Foroughi, Harry Stebbings
In 2024, AppLovin CEO Adam Faroge received $83 million in compensation contingent on stock performance while executing a radical strategic pivot that slashed the workforce by 50% and eliminated C-level roles to prioritize AI-driven efficiency. This restructuring transformed the company into a lean operation with a 400-person engineering core generating $10 million in EBITDA per employee, enabling triple-digit revenue growth and an 84% EBITDA margin through aggressive share buybacks and a shift to performance-based advertising. Faroge's approach, which integrates AI into 80–90% of code production and merges product management with engineering, aims to secure a potential $1 trillion valuation driven by Connected TV expansion rather than traditional social networking models.
- The Diary Of A CEO2h 0m
Sex Expert: What Women Actually Need To Enjoy Sex
Dr. Reena Malik outlines a comprehensive framework for sexual health that links declining intimacy among young adults to lifestyle factors like screen addiction, stress, and poor diet. The presentation details four pillars of optimization—nutrition, cardiovascular and pelvic floor exercise, environmental stress management, and anatomical knowledge—while emphasizing how erectile dysfunction often serves as an early warning for heart disease. By prioritizing these physiological and behavioral adjustments, individuals can improve longevity and combat the modern loneliness epidemic before considering medical interventions like testosterone replacement therapy.
- The Economist10 min
This vaccine could stop the next pandemic | The Economist
Advances in immunology over the last 15 years, highlighted by research from Mihaly Netea at Radboud University and a 2024 Stanford study, demonstrate that vaccines like BCG can epigenetically "train" the innate immune system to provide broad-spectrum protection. This emerging approach aims to deploy universal vaccines as a strategic bridge at the onset of pandemics or before flu seasons to maintain societal stability while waiting for highly specific variants to be addressed. Although current findings are limited by species differences, the proposed strategy envisions a complementary model where these broad-acting shots work alongside traditional vaccines to buy critical time against diverse pathogens.
- Y Combinator39 min
Replit's CEO On The Only Two Jobs Left In The Company Of The Future
Replit recently secured $400 million in Series D funding to achieve a $9 billion valuation while executing a strategic pivot toward "AI-native developers" who build software through natural language interactions with their Agent 4 system. By abstracting traditional coding behind multimodal AI agents, the platform enables non-engineers to rapidly deploy applications and reduce development costs by up to 70%, effectively shifting the company's focus from technical setup to high-level business orchestration. This product-led growth model empowers a diverse range of users, from solo entrepreneurs to enterprise teams, to accelerate idea velocity and build internal tools without requiring deep programming expertise or large engineering budgets.
Replit CEO: Why the SaaS Apocalypse is Justified & Why Coding Models are Plateauing | Amjad Masad
In March 2025, Replit CEO Amjad Massad declared a strategic pivot from traditional coding instruction to agentic creation, leveraging Opus 4.6 to embed autonomy directly into foundation models while maintaining a multi-provider architecture that balances Anthropic's session length with Google Gemini's cost efficiency. The company now targets enterprise operations to displace vertical SaaS through maintainable, self-correcting AI agents, prioritizing market dominance over immediate margin optimization despite significant infrastructure costs. This approach acknowledges the obsolescence of legacy IDEs while navigating regulatory hurdles, such as App Store delays, to capture value in an expanding total addressable market for automated software generation.