Latest Interviews
Showing 841–855 of 4,776 transcripts.
Clear all filters- Dwarkesh Patel1h 36m
Ilya Sutskever – We're moving from the age of scaling to the age of research
SSI is shifting from the era of pure scaling to a focused "age of research" that prioritizes robust generalization and biologically inspired learning mechanisms to overcome the current disconnect between model evaluation scores and real-world utility. The organization aims to deploy superintelligent systems within five to ten years that care for all sentient life through a strategic blend of rapid capability acquisition and gradual societal integration. This approach anticipates that as these human-like learners drive unprecedented economic growth, industry competition and government intervention will eventually converge on safety-focused architectural principles.
- 80,000 Hours1h 59m
Fertility declined 4.5x faster after 2016. Why?
This discussion analyzes the accelerating global decline in fertility driven by expanded non-child options, shifting social norms, and the economic independence of women rather than financial cost alone. Speakers Rob and Louisa contrast these macro trends with personal experiences of intensive parenting pressures, medical underservice for pregnancy, and strategies for balancing career and childcare in an era where AI may soon reduce labor market urgency. The dialogue concludes that modern parental anxiety often stems from historical inaccuracies about attachment and care, urging a shift toward realistic expectations rather than the "intensive parenting" ideal.
- Goldman Sachs7 min
Why Stocks Are Getting Wild
Driven by surging expectations of a Federal Reserve rate cut, equity markets are experiencing heightened volatility that has prompted investors to rotate capital from information technology into defensive sectors like healthcare and financials. Systematic momentum triggers and reduced liquidity have created selling pressure estimated at up to $60 billion in the near term, while strategists recommend hedging large-cap concentration through equal-weighted indices and VIX call spreads to mitigate downside risk.
Base44’s Founder, Maor Shlomo on How Vibe Coding Will Kill SaaS
Base44 founder Mayol sold his solo-founder bootstrap business to Wix for $80 million, a deal structured to maintain a lean product team while leveraging Wix's infrastructure, ultimately driving the acquired company to over $100 million in annual revenue. Mayol leveraged this exit to pivot his strategic focus toward the emerging "vibe coding" category, predicting that AI-generated, vertically integrated software will eclipse traditional SaaS models by prioritizing user-owned applications and eliminating feature bloat. Drawing on his experience scaling Base44 through a prompt-only workflow, Mayol now advises investors to prioritize startups with deep infrastructure moats over commoditized prompting layers, citing the shift toward non-consolidated market dynamics and the imminent zero-cost model pricing.
Inside Thrive Capital: Investing in OpenAI, Wiz, Cursor, Nudge, Physical Intelligence
Thrive Capital and partner Philip Rossetti outline a concentrated investment strategy that targets the emerging hardware renaissance and software leaders like OpenAI and Cursor, prioritizing founders who aggressively pursue market dominance. By leveraging deep partnerships with ex-Elon Musk and ex-OpenAI talent, the firm has backed transformative ventures such as Mesh Optical, Nudge, and the security giant Wiz, which secured the largest startup acquisition in history. This approach focuses on long-term physical intelligence and AI infrastructure, betting on young, talent-dense teams to drive geometric growth while navigating complex geopolitical and technical shifts.
- a16z59 min
The 2045 Superintelligence Timeline: Epoch AI’s Data-Driven Forecast
Yafah Edelman, David Owen, Marco Mascorro, Erik Torenberg, Kirsten, Jeff
Speakers analyze current AI spending as a signal of immediate value rather than a bubble, noting that while rapid compute growth and data center scaling are underway, future profitability hinges on whether large model investments yield proportional returns. The discussion forecasts rapid economic integration with potential GDP gains of 30% under AGI scenarios, alongside a 20-30% risk of a sudden unemployment spike that could trigger immediate government intervention. Looking toward technical milestones, the event projects significant breakthroughs in mathematical problem-solving and robotics within five years, while warning that traditional benchmarks will soon saturate as the industry shifts toward measuring real-world system performance.
- Goldman Sachs17 min
What’s Driving the Surge in Deal-Making?
Stephan Feldgoise, Allison Nathan, Stefan Feldgauis
Goldman Sachs reports that 2025 witnessed a historic surge in M&A activity, with billion-dollar transactions doubling and late-year volumes matching 2021 peaks despite tariff-related slowdowns. This resilience was driven by the convergence of aggressive buyer appetites, widened capital markets, and a strategic pivot by boards toward long-term AI and biotech consolidation across the Americas and Europe. Looking ahead to 2026, the firm maintains a cautiously bullish outlook anticipating sustained deal mandates, though geopolitical instability and credit market volatility remain the primary risks to this trajectory.
- Goldman Sachs16 min
The Apollo Theater’s Michelle Ebanks: Preserving Legacy and Celebrating Harlem's Cultural Scene
Apollo Theater President and CEO Michelle E. Banks, joined by Megan Hogan, outlines the historic venue's evolution from a 1934 Harlem Renaissance hub into a modern civic engine that blends performing arts with social advocacy. The institution sustains this mission through a hybrid financial model that funds artistic risk alongside voter registration and education initiatives, while innovating via omni-channel content strategies to reach global audiences. Leadership emphasizes that the organization's relevance depends on deep community accountability, successfully leveraging its legacy to launch careers ranging from Ella Fitzgerald to contemporary artists like Emmanuel Gerard.
- Milken Institute35 min
What Does Smart Implementation of AI in Health Look Like? | Future of Health Summit 2025
Michael Milken, Amy Gleason, Eric Lefkofsky
The Center for Medicare and Medicaid Services is accelerating a $2 trillion annual overhaul by deploying AI-driven interoperability frameworks and consolidating fragmented data to eliminate systemic waste projected to exceed $10 trillion by 2034. Personal case studies illustrating severe diagnostic delays have catalyzed recruitment of top tech talent to build a unified provider directory and a personal AI health companion designed to guide patients through complex care journeys. By setting government infrastructure guardrails while allowing private sector innovation, this strategic vision aims to transform healthcare from a resource-draining liability into a predictive, efficient ecosystem capable of preventing costly medical events.
- The Economist8 min
How strong is Iran’s regime?
Nicolas Pelham, Adam Roberts, Nick, Ed
Iran's strategic pivot from a proxy-heavy "forward defense" to a missile-centric approach follows the erosion of its Syrian alliances, while the regime grapples with Supreme Leader Ali Khamenei's frailty and a shifting succession landscape dominated by factional money rather than ideology. To maintain power amidst a secular populace, the leadership is adopting nationalist narratives and rebranding the nuclear program as a permanent national asset, signaling a retreat from revolutionary theocracy. This reinvention faces an existential conflict between the public's desire for global integration and the Islamic Revolutionary Guard Corps' vested interest in preserving a closed economy that fuels its monopolies.
- a16z1h 4m
Robinhood CEO: Making Everyone An Owner
Vlad Tenev, Alex Rampell, Erik Torenberg
Robinhood co-founder Vlad Tenev outlines a strategy to transform the company into a comprehensive wealth management platform by leveraging its retail user base for tokenized securities, prediction markets, and democratized IPO access. He argues that broad asset ownership and egalitarian distribution models are essential to align societal stability with technological progress, particularly regarding rapid AI adoption. Tenev further posits that overcoming historical regulatory paradoxes and rebuilding trust after the 2021 GameStop liquidity crisis requires a shift toward self-custody solutions and a rejection of financial nihilism in favor of diversified, long-term investor engagement.
$635M Exit → $600M Fund: David Ulevitch on Building a16z’s Hottest New Fund
American Dynamism leverages a strategy of asymmetric military capability and supply chain sovereignty to counter China's industrial dominance by investing heavily in deep-tech sectors ranging from nuclear energy and hypersonics to critical mineral extraction. The firm distinguishes its portfolio, which includes high-profile firms like Anduril and Radiant Nuclear, by prioritizing talent magnetism and authentic operational speeds that drive rapid deployment of hardware solutions. Looking forward, the organization will host its third annual summit in Washington D.C. to coincide with the U.S. 250th anniversary, marking a critical inflection point as these companies transition from development to large-scale customer deployment.
- Milken Institute31 min
Forging Asset Owner Alliances for Capital Deployment: Brazil & Beyond | Global Investors' Symposium
Dan Carol, Régine Clément, Amy Hepburn, Anna Murray, Kirsten Simpson
Major institutional investors, including the Ontario Teachers' Plan and the Australian Future Fund, are advancing climate strategies by integrating systemic risk analysis and direct engagement into fiduciary duties despite contrary media narratives. This shift is characterized by a pivot from simple net-zero declarations to active decarbonization tactics, such as acquiring fossil assets to transition them and investing in supply chains rather than solely targeting "green" sectors. As these entities collaborate through networks like the Investor Leadership Network, they are establishing new frameworks for blended finance and preparing high-stakes engagements for upcoming COP processes to drive tangible capital deployment.
- 80,000 Hours1h 44m
The American Public Kinda Hates AI. Why Exactly? | Dr Yam, Pew Research Center
Dr Yam, Eileen Yam, Rob Wiblin
A comprehensive Pew Research Center study of over 5,000 U.S. adults and 1,000 AI experts reveals a stark optimism gap, with experts predicting significant productivity and economic gains while the public increasingly fears job displacement and the erosion of human connection. While experts trust AI with critical decisions and anticipate self-improving systems within five years, the general public maintains deep skepticism, demanding greater control over AI applications in domains ranging from marriage to governance. This divergence is further complicated by demographic disparities, particularly along gender lines, and a shared concern regarding AI-generated misinformation and the lack of effective regulatory oversight by industry or government.
Peter Thiel and Softbank Sell NVIDIA - Why? & Why VC Will Hit $1TRN and The Opening of Retail
Peter Thiel, Tomasz Tunguz, Jason Lemkin, Rory O'Driscoll, Harry Stebbings
Cursor secured a $2.3 billion investment at a $30 billion valuation by promising 30–70% productivity gains for a developer market valued in the trillions, while relying on its lean 30-person structure to maintain high margins. The discussion contextualizes this deal within a volatile financial environment marked by AI supply constraints, macroeconomic stress signals, and a venture capital shift toward late-stage liquidity over traditional IPOs. Analysts project a future where three to four years of rapid disruption will consolidate the market, with Cursor competing against hyperscalers for dominance through deep workflow integration and proprietary model efficiency.