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Aprea Therapeutics Appoints Industry Veteran Eugene Kennedy, MD, as Chief Medical Advisor

  • Aprea Therapeutics, Inc. announced the appointment of Eugene (Gene) Kennedy, MD, as Chief Medical Advisor.
  • Dr. Kennedy joins following early clinical proof-of-concept data from the Phase 1 dose-escalation study of the WEE1 inhibitor APR-1051 in patients with advanced solid tumors.
  • He brings over 20 years of experience in oncology clinical development, regulatory strategy, and senior corporate leadership across public and private biotechnology firms.
  • CEO Oren Gilad stated Dr. Kennedy's expertise will support optimizing dose and patient selection for the WEE1 program while advancing the DNA damage response (DDR) pipeline.
  • Dr. Kennedy currently serves as fractional Chief Medical Officer at Percheron Therapeutics, overseeing a Phase 2 immuno-oncology checkpoint inhibitor program.
  • His prior roles include Chief Medical Officer positions at Carisma Therapeutics, Galera Therapeutics, Innovative Cellular Therapeutics, Lumos Pharma, and NewLink Genetics.
  • Dr. Kennedy previously advanced an NDA filing for a radiation-induced oral mucositis therapy at Galera and led first-in-human trials for cell therapies at Carisma and Innovative Cellular Therapeutics.
  • Before entering industry, he was an Associate Professor of Surgery at Thomas Jefferson University, specializing in pancreatic and hepatobiliary surgery.
  • Aprea's clinical pipeline includes APR-1051, an oral WEE1 kinase inhibitor, and ATRN-119, an ATR inhibitor, both targeting solid tumors.
  • The company's strategy focuses on exploiting cancer-specific vulnerabilities to minimize damage to healthy cells across indications such as ovarian, endometrial, colorectal, prostate, and breast cancers.
  • The press release includes standard forward-looking statements regarding clinical trial timing, regulatory submissions, and financial projections subject to risks and uncertainties.