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Dicerna Initiates PHYOX™4 Trial of Nedosiran for Primary Hyperoxaluria Type 3

LEXINGTON, Mass.--(BUSINESS WIRE)--Dicerna Pharmaceuticals, Inc. (Nasdaq: DRNA) (the “Company” or “Dicerna”), a leading developer of investigational ribonucleic acid interference (RNAi) therapeutics, today announced initiation of patient dosing in the Company’s PHYOX™4 clinical trial to assess its lead investigational candidate, nedosiran, for the treatment of primary hyperoxaluria (PH) type 3 (PH3). The study will evaluate the safety and efficacy of a single dose of nedosiran in participants with PH3. PH is a family of ultra-rare, life-threatening genetic disorders that initially manifest with complications in the kidneys. Nedosiran is in development for PH1, PH2 and PH3.