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John Stamos and Jodie Sweetin reunite for "The (Second) Talk" with Cologuard® tests, encouraging colon cancer screening

ABT
  • Abbott launched "The (Second) Talk" campaign on March 24, 2026, to encourage adults aged 45+ to discuss & get screened for colorectal cancer.
  • The campaign reunites actors John Stamos & Jodie Sweetin in a sitcom-style skit to reduce the awkwardness surrounding colon cancer conversations.
  • Colorectal cancer is identified as the second-leading cause of cancer-related deaths & the number one cancer killer of people under 50.
  • The Cologuard test is an FDA-approved, noninvasive screening option for average-risk adults 45+ that requires no special preparation or dietary changes.
  • The test is prescribed by a healthcare provider, shipped to the patient's home, & allows for self-collection without leaving the house.
  • Early detection of colorectal cancer results in a 91% five-year survival rate, while the Cologuard Plus test detected 95% of all colon cancers & many precancers in clinical studies.
  • The Cologuard & Cologuard Plus tests are included in national screening guidelines from the American Cancer Society & the U.S. Preventive Services Task Force.
  • Since 2014, the Cologuard test has been used for screening more than 23 million times.
  • The campaign video & additional information are available at Cologuard.com/TheTalk.