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Serina Therapeutics to Present at the 5th LNP Formulation & Process Development Summit

  • Serina Therapeutics announced that Chief Development Officer Randall Moreadith, MD, PhD, will present at the 5th LNP Formulation & Process Development Summit in Boston on April 7, 2026.
  • The presentation will feature data on novel lipid nanoparticles built entirely on Serina's POZ Platform to address the immunogenicity dilemma associated with standard PEG-lipids.
  • Preclinical rat studies showed that the POZ-lipid failed to elicit an antibody response, unlike standard PEG-lipids which trigger IgM & IgG responses & are linked to serious adverse events.
  • Serina is advancing a replacement strategy for ionizable lipids, another essential LNP component implicated in safety concerns.
  • Preliminary results include a novel polymer-lipid designed to bind a broad range of oligonucleotide payloads.
  • Serina's proprietary POZ Platform utilizes poly(2-oxazoline), a synthetic water-soluble polymer, to improve drug loading control & release precision for subcutaneous injections.
  • The POZ Platform aims to enhance the efficacy & safety profiles of small molecules, RNA-based therapeutics, & antibody-based drug conjugates.
  • Pfizer holds a non-exclusive license agreement to utilize Serina's POZ polymer technology for lipid nanoparticle drug delivery formulations.
  • Serina is headquartered in Huntsville, Alabama, on the campus of the HudsonAlpha Institute of Biotechnology.