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UPDATE -- Alamar Biosciences and Nightingale Health to Lead UK Biobank 80,000-Sample Neurodegenerative Disease Study

  • Alamar Biosciences & Nightingale Health launched the UK Biobank vanguard study (UKB-PRISM) to measure blood-based protein biomarkers for neurodegenerative diseases.
  • The study will utilize Alamar's NULISA platform to analyze hundreds of circulating protein biomarkers in 80,000 blood samples from UK Biobank participants.
  • Testing will be conducted in Nightingale Health's laboratories to detect low-abundance proteins at a sensitivity previously unachievable at scale.
  • Findings will create one of the world's largest open-access resources for identifying early molecular indicators of brain health decades before diagnosis.
  • The project aims to understand Alzheimer's & Parkinson's disease as overlapping conditions with shared biological roots by measuring signals before symptoms emerge.
  • Funding is provided by The Michael J. Fox Foundation, Alzheimer's Research UK, & LifeArc, with completion expected by the end of 2027.
  • Results will be integrated with existing UK Biobank imaging, genetic, metabolomic, & lifestyle data to enhance disease research & early detection capabilities.
  • Upon completion, the full dataset will be made available to approved researchers worldwide via the UK Biobank Research Analysis Platform.